Preliminary in-vitro evaluation of marketed formulations for antacid activity

Dhawal, Pranjali; Barve, Siddhivinayak

doi:10.18203/2319-2003.ijbcp20195764

Cited by 4 publications

(9 citation statements)

References 6 publications

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“…The pH of the solution was noted, and the samples were processed for ANC and ANP if the PAT showed a result of pH above 3.5 (food and drug administration, HHS, part 331). 6…”

Section: Preliminary Antacid Testmentioning

confidence: 99%

“…Upon using KHPh for determining the normality of NaOH and HCl, the values were substituted in the formula and ANC was calculated. 6,17…”

Section: Acid Neutralizing Capacitymentioning

confidence: 99%

“…The pH time profile was recorded throughout the test until the pH of the solution fell below 3.0 and it was constant for a minute. 6,19…”

Section: Acid Neutralizing Potentialmentioning

confidence: 99%

“…The sample solution was added to the flask containing 0.1 N HCl and time taken for pH to rise above 3.5 was recorded. 6…”

Section: Onset Of Actionmentioning

confidence: 99%

“…4 This study is an extended research to our previously published work on different antacid formulations. 6 In this paper, we aimed to determine the pH of F1 to frequently used antacid powder F2 and to study the antacid properties of both the marketed formulations. The need for evaluating different antacid formulations rely on the fact that medical institutions should be aware of composition, efficacy, dosage and side effects of different antacid formulations.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of two marketed effervescent fast relief formulations for antacid activity-an in vitro study

Dhawal¹,

Barve²,

Sen-Roy

2021

Int J Basic Clin Pharmacol

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Background: Hyper-acidity is excessive formation of acid (pH=1.5-3.5) in the stomach by parietal cells which causes a burning sensation in the chest. The preservation of gastric acid insult is crucial because of the implications of hyperacidity in gastroesophageal reflux disease (GERD), peptic ulcers and duodenal ulcers. Acidity is controlled by use of some over-the-counter (OTC) antacid formulations containing magnesium or aluminum hydroxides.Methods: In the present study, the preliminary antacid test (PAT), the pH acid neutralizing capacity (ANC), acid neutralizing potential (ANP) along with buffering capacity of two well-known quick release formulations (F1 [Digene Ultra Fizz] and F2 [a standard, commercially available product]) were determined. Results: According to US pharmacopeia USP, both the antacid formulations passed the PAT test. PAT results revealed that the pH of the acid-antacid solution was higher in F1 (8.20±0.02) as compared to F2, (6.53±0.01). The ANC results revealed that F1 (46.89±0.6 mEq/dosage) had higher neutralizing capacity as compared to F2(30.12±1.3 mEq/dosage). Higher ANP was observed for F1 (245 mins), and it was 2.7 times that of F2 (90 min). The onset of action for both the antacids was <2 seconds. Additionally, buffering capacity was evidently observed during ANP analysis in the case of F1. Independent T test performed for all the tests revealed that the data obtained was highly significant (p<0.01).Conclusions: F1 showed high antacid and buffering properties when tested in vitro. The present study highlights the need for future research on specific OTC non-prescribed antacid formulations with respect to their price, efficacy and side effects.

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“…The pH of the solution was noted, and the samples were processed for ANC and ANP if the PAT showed a result of pH above 3.5 (food and drug administration, HHS, part 331). 6…”

Section: Preliminary Antacid Testmentioning

confidence: 99%

“…Upon using KHPh for determining the normality of NaOH and HCl, the values were substituted in the formula and ANC was calculated. 6,17…”

Section: Acid Neutralizing Capacitymentioning

confidence: 99%

“…The pH time profile was recorded throughout the test until the pH of the solution fell below 3.0 and it was constant for a minute. 6,19…”

Section: Acid Neutralizing Potentialmentioning

confidence: 99%

“…The sample solution was added to the flask containing 0.1 N HCl and time taken for pH to rise above 3.5 was recorded. 6…”

Section: Onset Of Actionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of two marketed effervescent fast relief formulations for antacid activity-an in vitro study

Dhawal¹,

Barve²,

Sen-Roy

2021

Int J Basic Clin Pharmacol

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Comparative study of sodium bicarbonate- and magnesium hydroxide-based gastric antacids for the effectiveness of Salmonella delivered Brucella antigens against wild type challenge in BALB/c mice

Hewawaduge

Yang

Jeong

et al. 2021

Pathogens and Disease

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We compared the effects of two antacid formulations based on sodium bicarbonate and magnesium hydroxide on a Salmonella-delivered oral Brucella live attenuated vaccine. We conducted a series of in vitro and in vivo experiments to investigate the pH buffering capacity, buffering longevity, and the effects of these formulations on the survival of Salmonella under neutralized pH conditions and its impact on immune responses. Magnesium hydroxide had a greater, stable, and prolonged buffering capacity than sodium bicarbonate and was safer when administered orally. Oral administration of sodium bicarbonate resulted in discomfort as reflected by mouse behavior and mild muscle tremors, whereas mice treated with magnesium hydroxide and PBS were completely normal. Gastric survival studies using BALB/c mice revealed that a higher number of Salmonella reached the intestine when the magnesium hydroxide-based antacid buffer was administrated. Co-administration with attenuated Salmonella secreting Brucella antigens, SodC, and Omp19 along with individual antacid formulations, significantly enhanced the antigen-specific protective immune responses against virulent Brucella challenge. Together, our results indicated that the pre vaccinated oral administration of bicarbonate-citric acid or magnesium hydroxide-based neutralizing buffers significantly counteract stomach acidity by maintaining the viability of an oral enteric vaccine formulation.

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An expert opinion on antacids: A review of its pharmacological properties and therapeutic efficacy

Shetty

Vishwanath²

2022

F1000Res

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Acidity caused by common gastric conditions such as non-ulcer dyspepsia, duodenal ulcer, gastric ulcer, stress gastritis, gastroesophageal reflux disease (GERD), pancreatic insufficiency, bile acid-mediated diarrhea, biliary reflux, and constipation can be treated by administration of potent and efficacious acid suppressant (antisecretory) agents such as antacids, histamine H2 receptor blockers, and proton pump inhibitors (PPIs). Antacids provide symptomatic relief from hyperacidity as well as other associated conditions by neutralizing the gastric acid directly, thereby raising the gastric pH, attenuating the pepsin activity, restoring acid-base balance, and increasing prostaglandin and bicarbonate secretion. The effectiveness of antacids is determined by its acid neutralizing capacity (ANC) and buffering capacity. Antacids containing a combination of aluminum hydroxide, magnesium hydroxide, and other ingredients such as those present in Digene showed better therapeutic efficacy even at low dosage with fewer side effects, persistent increase in gastric pH, faster and longer duration of pain relief, and fast relief from gas. Various clinical studies suggest that to obtain fast symptomatic relief, the treating physician can utilize antacids with the highest neutralizing capacities like Digene.

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Preliminary in-vitro evaluation of marketed formulations for antacid activity

Cited by 4 publications

References 6 publications

Comparison of two marketed effervescent fast relief formulations for antacid activity-an in vitro study

Comparison of two marketed effervescent fast relief formulations for antacid activity-an in vitro study

Comparative study of sodium bicarbonate- and magnesium hydroxide-based gastric antacids for the effectiveness of Salmonella delivered Brucella antigens against wild type challenge in BALB/c mice

An expert opinion on antacids: A review of its pharmacological properties and therapeutic efficacy

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