Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T

Takeuchi, Mayumi; Matsuzaki, Kei; Harada, Masafumi

doi:10.1007/s00330-011-2215-2

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…Proton MR spectroscopy may identify the presence of mucinous material containing N-acetyl mucinous compounds, and can provide helpful information in distinguishing mucinous and nonmucinous ovarian tumours. Therefore, MR spectroscopy helps to diagnose the subtypes of ovarian tumours and may contribute to the adequate treatment, thus improving management of these patients [ 25 ].…”

Section: Approach To Adnexal Massesmentioning

confidence: 99%

MR imaging of ovarian masses: classification and differential diagnosis

et al. 2015

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ObjectiveWe propose a Magnetic Resonance Imaging (MRI) guided approach to differential diagnosis of ovarian tumours based on morphological appearance.BackgroundCharacterization of ovarian lesions is of great importance in order to plan adequate therapeutic procedures, and may influence patient’s management. Optimal assessment of adnexal masses requires a multidisciplinary approach, based on physical examination, laboratory tests and imaging techniques. Primary ovarian tumours can be classified into three main categories according to tumour origin: epithelial, germ cell and sex cord-stromal tumours. Ovarian neoplasms may be benign, borderline or malignant. Using an imaging-guided approach based on morphological appearance, we classified adnexal masses into four main groups: unilocular cyst, multilocular cyst, cystic and solid, predominantly solid. We describe MR signal intensity features and enhancement behaviour of ovarian lesions using pathologically proven examples from our institution.ConclusionMRI is an essential problem-solving tool to determine the site of origin of a pelvic mass, to characterize an adnexal mass, and to detect local invasion. The main advantages of MRI are the high contrast resolution and lack of ionizing radiation exposure. Although different pathological conditions may show similar radiologic manifestations, radiologists should be aware of MRI features of ovarian lesions that may orientate differential diagnosis.Teaching Points• Diagnostic imaging plays a crucial role in detection, characterization and staging of adnexal masses.• Characterization of an ovarian lesion may influence patient’s management.• Different pathological conditions may have similar radiologic manifestations.• Non-neoplastic lesions should always be taken into consideration.

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Section: Approach To Adnexal Massesmentioning

confidence: 99%

MR imaging of ovarian masses: classification and differential diagnosis

et al. 2015

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“…Takeuchi et al . conceded that their results also suggest contamination from other sources. The use of a powerful spectral analysis tool, such as the Quest algorithm, is imperative to allow contributions from overlapping spectral metabolites to be quantified.…”

Section: Discussionmentioning

confidence: 96%

“…However, one possible contaminant may simply be polyunsaturated fatty acids (41). In addition, Takeuchi et al (42) suggested that a peak detected at approximately 2 ppm in a 1 H MRS study of ovarian tumours could be attributed to N-acetyl mucinous compounds (i.e. those containing the glycosylated protein mucin).…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence in the literature that mucin-15 is expressed in the human placenta to varying degrees at different stages of gestation (43), but equally there is evidence that glutamine is present in ovarian tumours (44). Takeuchi et al (42) conceded that their results also suggest contamination from other sources. The use of a powerful spectral analysis tool, such as the Quest algorithm, is imperative to allow contributions from overlapping spectral metabolites to be quantified.…”

Section: Discussionmentioning

confidence: 99%

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¹ H MRS: a potential biomarker of in utero placental function

et al. 2015

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The placenta is a temporary organ that is essential for a healthy pregnancy. It performs several important functions, including the transport of nutrients, the removal of waste products and the metabolism of certain substances. Placental disorders have been found to account for over 50% of stillbirths. Despite this, there are currently no methods available to directly and non‐invasively assess placental function in utero. The primary aim of this pilot study was to investigate the use of 1H MRS for this purpose. 1H MRS offers the possibility to detect several placental metabolites, including choline, lipids and the amino acids glutamine and glutamate (Glx), which are vital to fetal development and placental function. Here, in utero placental spectra were acquired from nine small for gestational age (SGA) pregnancies, a cohort who are at increased risk of perinatal morbidity and mortality, and from nine healthy gestation‐matched pregnancies. All subjects were between 26 and 39 weeks of gestation. Placenta Glx, choline and lipids at 1.3 and 0.9 ppm were quantified as amplitude ratios to that of intrinsic H2O. Wilcoxon signed rank tests indicated a significant difference in Glx/H2O (p = 0.024) between the two groups, but not in choline/H2O (p = 0.722) or in either lipid/H2O ratio (1.3 ppm, p = 0.813; 0.9 ppm, p = 0.058). This study has demonstrated that 1H MRS has potential for the detection of placental metabolites in utero. This warrants further investigation as a tool for the monitoring of placental function. Copyright © 2015 John Wiley & Sons, Ltd.

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“…NAA is reverberant at 2.0 ppm, it is called neuronal marker [15]. Some studies [16] detected NAA metabolites in both solid and cystic elements of the mucinous cystadenoma. A study conducted by El Sorogy et al (2012) also detected the NAA signal in all cases of mature cystic teratomas, denoting the presence of a neural component (ectodermal tissue) [4].…”

Section: Discussionmentioning

confidence: 99%

Value of magnetic resonance spectroscopy in assessment of adnexal lesions

Ibrahim

Fattah

Metwally

et al. 2019

Egypt J Radiol Nucl Med

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Background: The purpose of this study is to investigate the role of proton MR spectroscopy (1H-MRS) in the characterization and diagnosis of ovarian lesions. Results: From October 2015 to October 2017, a total of 57 female patients (65 adnexal lesions; 8 cases were bilateral) were included. The examined lesions were classified according to their histopathological findings, (37 (57%) benign lesions, 4 (6%) borderline lesions, and 24 (37%) malignant lesions). The mean choline/creatinine (CHO/ Cr) ratio was 1.29 ± 0.98 SD for malignant lesions, while the mean value in borderline lesions was 0.63 ± 0.15 SD, and the mean value for the benign lesions was 0.65 ± 0.34. Therefore, the mean CHO/Cr ratio was much higher in malignant than in benign lesions, which was statistically significant (P ≤ 0.001) as well as between the borderline and invasive lesions (P = 0.05), but not between the benign and borderline lesions. The diagnostic performance of conventional MRI in diagnosing adnexal lesions was 100%, specificity was 76%, and accuracy was 86%. However, MRS individual diagnostic performances are the following: sensitivity 89%, specificity, and 100% with an accuracy of 95%. Conclusion: MRS proved to be an accurate and efficient method for the analysis of adnexal lesions and in differentiation between benign and malignant tumors.

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Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T

Cited by 11 publications

References 25 publications

MR imaging of ovarian masses: classification and differential diagnosis

MR imaging of ovarian masses: classification and differential diagnosis

¹ H MRS: a potential biomarker of in utero placental function

Value of magnetic resonance spectroscopy in assessment of adnexal lesions

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Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T

Cited by 11 publications

References 25 publications

MR imaging of ovarian masses: classification and differential diagnosis

MR imaging of ovarian masses: classification and differential diagnosis

1 H MRS: a potential biomarker of in utero placental function

Value of magnetic resonance spectroscopy in assessment of adnexal lesions

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¹ H MRS: a potential biomarker of in utero placental function