Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy

Welch, K. M. A.; Levine, Steven R.; D’Andrea, Giovanni; Schultz, Lonni; Helpern, J. A.

doi:10.1212/wnl.39.4.538

Cited by 186 publications

(122 citation statements)

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“…Interestingly, using magnetic resonance spectroscopy (MRS), abnormally elevated cerebellar intracellular pH has been demonstrated between attacks of EA2, returning to normal after acetazolamide administration [22]. MRS studies in migraine patients have failed to show abnormal intracellular pH even in prolonged attacks of migraine with aura or hemiplegic migraine [23,24].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability of acetazolamide in migraine prophylaxis: A randomised placebo-controlled trial

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability of acetazolamide in migraine prophylaxis: A randomised placebo-controlled trial

et al. 2002

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“…The predisposition to attack recurrence in migraine is reflected in functional brain changes that fluctuate over the migraine cycle, such as those related to the processing of sensory stimuli and cortical reactivity (12), and to mitochondrial energy metabolism (13)(14)(15). Migraine is supposed to be a complex polygenic disorder where the genetic load sets a threshold that is influenced by environmental and hormonal factors (16).…”

Section: Pathophysiologymentioning

confidence: 99%

Targeting pericranial nerve branches to treat migraine: Current approaches and perspectives

et al. 2015

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Background: Migraine is a highly prevalent neurological disorders and a major individual and societal burden. Migraine is not curable at the present time, but it is amenable to acute symptomatic and preventive pharmacotherapies. Summary: Since the latter are frequently unsatisfactory, other treatment strategies have been used or are being explored. In particular, interventions targeting pericranial nerves are now part of the migraine armamentarium. We will critically review some of them, such as invasive and noninvasive neurostimulation, therapeutic blocks and surgical decompressions. Conclusions: Although current knowledge on migraine pathophysiology suggests a central nervous system dysfunction, there is some evidence that interventions targeting peripheral nerves are able to modulate neuronal circuits involved in pain control and that they could be useful in some selected patients. Larger, well-designed and comparative trials are needed to appraise the respective advantages, disadvantages and indications of most interventions discussed here.

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“…First one, the vasogenic theory, suggests migraine as a form of vascular dysregulation and assumes the aura is initiated by a focal reduction in cerebral flow [3]. Second, the neurogenic theory, accepts migraine as a cranial disorder and assumes vascular changes are the result of neuronal dysfunction [4,5].…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness measurements in migraine patients during attack-free period

et al. 2015

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To identify any structural differences in macular choroidal thickness in migraine patients and compare them with that of control subjects by using spectral domain optic coherence tomography (SD-OCT). In this prospective study, choroidal thicknesses of 32 migraine patients during migraine attack-free period and 32 age- and sex-matched healthy subjects were measured using SD-OCT. All patients underwent a complete ophthalmic examination before the measurements. The migraine patients were classified into the migraine with aura group or the migraine without aura group. Migraine severity was assessed by visual analog scale (VAS), migraine disability questionnaire (Migraine Disability Assessment Score (MIDAS), and Wong-Baker faces pain rating scale. Thirty eyes of 32 subjects (31 female and 1 male) in the migraine group and 32 eyes of 32 subjects (31 female and 1 male) in control group were evaluated. In the study group, 16 patients suffered migraine without aura (MWA) and 16 patients were diagnosed as migraine with aura (MA). The mean subfoveal choroidal thickness (SFCT) was 353.3 ± 66.5 μm in the control group versus 304.3 ± 72.9 μm and 276.1 ± 61.4 μm in MWA and MA groups, respectively. The difference in SFCT between the migraine patients and the controls was significant (p < 0.001). Additionally, a moderate correlation was found between SFCT and the VAS score and W baker score (r = 0.48, p = 0.008 and r = 0.43, p = 0.02, respectively). The choroidal thickness was found to decrease significantly not only in migraine patients with aura but also in those without aura during the attack-free period.

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Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy

Cited by 186 publications

References 0 publications

Efficacy and tolerability of acetazolamide in migraine prophylaxis: A randomised placebo-controlled trial

Efficacy and tolerability of acetazolamide in migraine prophylaxis: A randomised placebo-controlled trial

Targeting pericranial nerve branches to treat migraine: Current approaches and perspectives

Choroidal thickness measurements in migraine patients during attack-free period

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