Preliminary Observations on Mental Disturbances Occurring in Patients under Therapy with Cortisone and ACTH

Clark, Lincoln D.; Bauer, Walter; Cobb, Stanley

doi:10.1056/nejm195202072460601

Cited by 133 publications

(38 citation statements)

References 29 publications

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“…The literature about corticosteroid-induced psychosis was published soon after their introduction in the 1950s [6,7]. But even today the nature of this relationship is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Acute Onset of Steroid Psychosis with Very Low Dose of Prednisolone in Sheehan's Syndrome

et al. 2006

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Abstract. Corticosteroid treatment is frequently associated with psychiatric disturbances. These adverse effects are unusual with low dose of corticosteroid. We describe a patient who rapidly developed a steroid-induced psychosis with very low dose of prednisolone. A 48-year-old woman of Sheehan's syndrome was admitted to hospital with insomnia, euphoric moods and visual hallucinations. She had taken prednisolone (10 mg in the morning and 5 mg at night) for 6 days before admission. These symptoms appeared after first dose of prednisolone. A diagnosis of acute psychosis was made. After improvement of acute psychosis with discontinuation, re-administration of prednisolone at a dose of 2.5 mg per day gave rise to agitation and insomnia. She recovered completely by gradual dosage increase of short-acting corticosteroid after the discontinuation of prednisolone.

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“…The literature about corticosteroid-induced psychosis was published soon after their introduction in the 1950s [6,7]. But even today the nature of this relationship is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Acute Onset of Steroid Psychosis with Very Low Dose of Prednisolone in Sheehan's Syndrome

et al. 2006

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“…Clark et aL (107,108) reported 7 cases of depression with ACTH-cortisone therapy and others have even reported suicide (109, 110). All showed retarded depression with or without paranoid ideations.…”

Section: Corticosteroidsmentioning

confidence: 99%

Drug-Induced Mood Disorders

Ananth¹,

Ghadirian²

1980

Int Pharmacopsychiatry

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Various drugs including antihypertensives, anxiolytics, antibiotics, antidepressants, corticosteroids, choline, indomethacin, levodopa, metronidazole, neuroleptics, oral contraceptives, sulphonamides and physostigmine have been reported to produce depression as a side effect. Clinically, these drug-induced depressions may go unnoticed and thus create therapeutic problems. Although causal relationship is difficult to establish, depression occurring during the course of drug treatment needs an evaluation of all the medications that the patient has been receiving. We believe that postpsychotic depressions include three types of depression: pendular depression — primarily disease related; chronic depression - primarily environment related, and amine-depletion depression - drug related. Thus, drug-induced depressions constitute a subgroup of postpsychotic depression. Clinically, it is essential to carefully monitor patients receiving drugs known to produce depression. Thus, prompt recognition of the drug-induced depressions may assist in initiating proper therapeutic measures.

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“…XV, NO. 6,1953 during a period of two and a half years on the wards of The Mount Sinai Hospital, New York City. The patients studied were hospitalized for a large variety of conditions (Table 1).…”

Section: Clinical Materialsmentioning

confidence: 99%

“…xv, NO. 6,1953 593 they felt that an abrupt improvement in the physical state was more likely to accentuate the euphoria. Depressions have been encountered which terminated in suicide.…”

Section: Review Of the Literaturementioning

confidence: 99%