Preliminary phytochemical analysis and evaluation of the antioxidant and anti-proliferative effects of <i>Plinia peruviana</i> leaves: an <i>in vitro</i> approach

Moraes, Greice Graziela; Mazziero, Maiara; Lovatto, Marina Ortiz; Dornelles, Rafaela Castro; Nogueira-Librelotto, Daniele Rubert; Reuter, Cézane Priscila; Ortolan, Silvio Augusto; Silva, Chana de Medeiros da; Manfron, Melânia Palermo

doi:10.1080/14786419.2019.1602827

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Cited by 5 publications

(1 citation statement)

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“…vinblastine, vincristine, paclitaxel, camptothecin, and topotecan) [28,29]. Several plant species and their derivatives exerted strong antiproliferative and proapoptotic effects in different types of cancer cell lines [30][31][32][33]. Additionally, the plants which contain high amounts of flavonoids in their structure are accepted in traditional medicine as chemotherapeutic and chemopreventive agents in some countries [34].…”

Section: Natural Productsmentioning

confidence: 99%

Investigation of antitumor properties of semi-synthetic flavonoid derivatives on gynecological cancer cell lines

Latif¹

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Section: Natural Productsmentioning

confidence: 99%

Investigation of antitumor properties of semi-synthetic flavonoid derivatives on gynecological cancer cell lines

Latif¹

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Unleashing the power of golden berry leaves to counteract cyclophosphamide's toll with antioxidant, anti-inflammatory, anti-apoptotic, and neurotransmitter boosting effects

AwadAllah,

Khalil,

AbulFadl

et al. 2025

Journal of Ethnopharmacology

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Jabuticaba [Plinia peruviana (Poir.) Govaerts]: a Brazilian fruit with a promising application against itraconazole-susceptible and -resistant Sporothrix brasiliensis

Waller

Peter

Hoffmann

et al. 2020

Natural Product Research

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Hydroalcoholic extract from Jabuticaba peels was evaluated for the chemical profile, antioxidant potential, cytotoxicity, and anti-Sporothrix brasiliensis activities against both dimorphic phases. Higher phenolic content (14.91±0.97) compared to flavonoid (2.05±1.00) associated with the ellagic acid (1.93 ± 0.03; LC-MS), and a good scavenging ability against ABST and DPPH radicals was noted. On MDBK cells, elevated cell viability (>90%) was demonstrated between 0.39-0.097 mg/ml (MTT assay). Mycelial (CLSI M38-A2) and yeast (CLSI M27-A3) phases of 18 isolates of Sporothrix brasiliensis from cats (n=8), dogs (n=8) and humans (n=2) were used. They were identified itraconazole-susceptible and itraconazoleresistant isolates in both phases, which were all inhibited (MIC of ≤1.56-6.25 mg/ml for both phases) and killed (MFC of ≤1.56-12.5 mg/ml for mycelial; ≤1.56-50 mg/ml for yeast) by Jabuticaba. For the first time, these findings highlighted the potential usefulness of hydroalcoholic extract from Jabuticaba peel as a promising antifungal against sporotrichosis.

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Preliminary phytochemical analysis and evaluation of the antioxidant and anti-proliferative effects of Plinia peruviana leaves: an in vitro approach

Cited by 5 publications

References 23 publications

Investigation of antitumor properties of semi-synthetic flavonoid derivatives on gynecological cancer cell lines

Investigation of antitumor properties of semi-synthetic flavonoid derivatives on gynecological cancer cell lines

Unleashing the power of golden berry leaves to counteract cyclophosphamide's toll with antioxidant, anti-inflammatory, anti-apoptotic, and neurotransmitter boosting effects

Jabuticaba [Plinia peruviana (Poir.) Govaerts]: a Brazilian fruit with a promising application against itraconazole-susceptible and -resistant Sporothrix brasiliensis

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