Preliminary Phytochemical and Toxicity Studies of Aqueous Leaf Extract of &amp;lt;i&amp;gt;Sida corymbosa&amp;lt;/i&amp;gt; Plant

Bakut, John Maiganga; Tende, Y.A.; Agyigra, Aksavdwa Isaac; Tende, Mojisola O.; Zezi, Abdulkadir Umar; Danjuma, Nuhu M

doi:10.4236/ajps.2020.1112140

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…The uterotonic activities of these standard agents and the pathways for contraction of the myometrium are well established (Arrowsmith and Wray, 2014;Jana et al, 2019). A variety of other medicinal plants have also shown uterotonic potential similar to the plant extract in this study: the fruits of Fiscus asperifolia (Watcho et al, 2011), rhizomes of Nymphaea alba (Bose et al, 2014), leaves of Spondias mombin (Pakoussi et al, 2018), roots of Azanza garckeana (Chanda et al, 2020), and leaf extract of Sida corymbosa (Bakut et al, 2020). The uterotonic potential of E. heterophylla has also been confirmed by Unekwe et al (2006), however the mechanism of action of the plant has been extensively explored in this present study.…”

Section: Discussionmentioning

confidence: 62%

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Elemo¹,

Akinyede²,

Oreagba³

et al. 2022

Pharmacol Toxicol Nat Med

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Background and Purpose: Euphorbia heterophylla Linn. (Euphorbiaceae) is a promising medicinal plant used as an oxytocic in folkloric medicine. The study investigated the uterotonic and abortifacient effects of the aqueous leaf extract of Euphorbia heterophylla (AEEH). Methods: GC-MS analysis of AEEH was done. In vitro experiment on the contractile activity of AEEH was conducted on the uterus of nulliparous female Sprague Dawley rats using an isolated organ bath. The abortifacient activity of the extract was determined in pregnant rats orally administered 50, 100, 200, and 400 mg/kg AEEH for five consecutive days. Results: GC-MS analysis of AEEH revealed high amounts of 1-butanol 3-methyl acetate, benzofuran,2,3-dihydro-, 2-methoxy-4-vinyl phenol, and sucrose. Some of the classes of compounds identified in the extract such as phenols, terpenoids, fatty acids, aldehydes, steroid, and glucoside have been associated with uterotonic and abortifacient properties. The extract (0.125-4 mg/mL) was able to enhance the contractile activity of uterine smooth muscles (EC50 = 3.39 × 10-1 mg/mL) similar to oxytocin (EC50 = 3.99 × 10-4 mg/mL) and acetylcholine (EC50=2.68 × 10-4 mg/mL). Pre-treatment with salbutamol, indomethacin, and stimulation in a calcium-deprived medium significantly (P<0.0001) reduced uterine contractions induced by cumulative concentrations of the aqueous extract. However, there was no significant change in uterine contraction in tissues pre-treated with atropine. The aqueous extract induced abortion in 50%, and 83.33% of the animals at 200, and 400 mg/kg respectively when orally administered to pregnant rats for five days. Conclusions: This study demonstrates the uterotonic and abortifacient effects of AEEH and supports the ethnomedicinal use of the plant as an oxytocic.

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Section: Discussionmentioning

confidence: 62%

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Elemo¹,

Akinyede²,

Oreagba³

et al. 2022

Pharmacol Toxicol Nat Med

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Sida corymbosa prevents seizures and memory deficit via inhibition of oxidative stress and neuronal loss in the hippocampus

Penda,

Kandeda,

Longo

et al. 2024

Heliyon

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Preliminary Phytochemical Analysis of Sida angustifolia Mill., Plant Specimen from Malvaceae Family

Dafare

Gadpayale²

2021

IJARSCT

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The present research paper represents the preliminary phytochemical screening of the crude extract of Sida angustifolia Mill., plant belongs to the Malvaceae family exposed to find out the presence of various bioactive components. The specimen shows the occurrence of Alkaloids, Flavonoids, Phytosterols, Carbohydrate, Phenolic compounds and Tannins mostly while Glycosides, Saponins, Proteins and Free Amino Acids and Gums and mucilage in trace amount. The diversity of phytochemicals found suggests that Sida angustifolia Mill., could serve as a source of useful drugs for future.

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Preliminary Phytochemical and Toxicity Studies of Aqueous Leaf Extract of <i>Sida corymbosa</i> Plant

Cited by 3 publications

References 9 publications

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Sida corymbosa prevents seizures and memory deficit via inhibition of oxidative stress and neuronal loss in the hippocampus

Preliminary Phytochemical Analysis of Sida angustifolia Mill., Plant Specimen from Malvaceae Family

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