Preliminary Phytochemical Evaluation and chemical Composition of Gum Isolated from Fenugreek Seeds

Al-Shamari, Bushra B. G.; Al-Ali, Rawdhah M. A.; Al-Sahi, Ali A. S.

doi:10.21608/jbaar.2020.119301

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…The positive ruthenium red test confirmed pCmG as a plant gum [ 60 , 61 ]. Apart from the primary metabolites, carbohydrates and reducing sugars, starch and all the secondary metabolites tested for were absent.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Kipo

Ofori-Kwakye

Kuntworbe

et al. 2023

The Scientific World Journal

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The development of a raw material into an acceptable pharmaceutical excipient involves evaluation of the physicochemical and formulation properties of the potential raw material. Results from these evaluations may serve as a guide to subsequent use of the substance. The objective of the study was to evaluate the physicochemical and microbiological properties of the stem bark gum of Cordia millenii tree in conventional release paracetamol tablets. From the physicochemical evaluations, the gum was slightly acidic and soluble in all the aqueous-based solvents, except 0.1 N HCl in which it was sparingly soluble. All the absorptive properties of the gum indicated tablet disintegrating potential for tablet formulation. The total ash of the gum was higher than that of the international standard gum arabic. Micromeritic properties of the gum indicated the need for a flow aid to improve its flowability. There were no harmful microorganisms detected in the gum. Aerobic organisms and moulds and yeast were detected within permissible limits. Tablets formulated using six different concentrations of gum dispersions as a binder were generally soft and failed the USP T80 standard of dissolution, indicating poor binding and drug releasing properties. Quality control properties of three different batches of tablets containing varying concentrations of the dry gum as a disintegrating agent were comparable to tablets containing equal concentrations of corn starch. The in vitro drug releases were similar at all-time points of drug evaluation. The gum can therefore be considered as a good disintegrant in the formulation of conventional release tablets.

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Section: Resultsmentioning

confidence: 99%

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Kipo

Ofori-Kwakye

Kuntworbe

et al. 2023

The Scientific World Journal

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“…Te authenticity of CAPG as a gum was confrmed by the Ruthenium red test [12,13]. Te presence of carbohydrates was tested by Molisch's reagent and conc.…”

Section: Phytochemical Screening Of Capgmentioning

confidence: 99%

“…Secondary metabolites tested for were alkaloids with Dragendorf's reagent [17,18], glycosides by bromine water test [19] and Keller-Kiliani test [20], tannins by lead acetate dilute solution test [21], and ferric chloride solution test [22]. Te detection of saponins was by the froth test [23]; free amino acids by the ninhydrin test [12]; and protein, steroids, and favonoids by procedures of Takur et al [24]. Other secondary metabolites that were tested for were terpenoids by Salkowski's test [20] and coumarins by the fuorescence test [25].…”

Section: Phytochemical Screening Of Capgmentioning

confidence: 99%

“…Depending on the method of purifcation and its efciency, compounds that may be present in the crude gum may be removed either partially or completely [32]. From Table 3, the positive result (pink) of the Ruthenium red test confrmed CAPG as a plant gum [12,14]. Te positive result for Molisch's test indicated the presence of carbohydrates and reducing sugars (hydrolysed constituents).…”

Section: Percentage Yield Purity and Authenticity Of Extractedmentioning

confidence: 99%

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Evaluation of the Physicochemical and Micromeritic Properties of Exudate Gum of Cussonia arborea Stem Bark in Conventional Tablet Formulation

Kipo,

Kuntworbe,

Boakye-Gyasi

et al. 2024

Journal of Chemistry

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Pharmaceutical excipients are classified based on the function(s) in the processing and/or finished product. However, functionality evaluations, procedures, and related acceptance criteria for excipients tend to depend on the dosage form, and assessment is usually done on a case-by-case basis. This means that any useful and reliable evaluation of the overall functionality-related properties is only possible within the context of the specific formulation method. This study evaluated the physicochemical, functional, and related properties of purified gum obtained from the stem bark of the Cussonia arborea tree. The purified gum was acidic (pH 5.32–5.50) with percentage (%) moisture content and insoluble matter of 13.33 ± 0.33 and 0.47 ± 0.01, respectively. Moreover, it was soluble in all the aqueous-based solvents but insoluble in all the organic solvents. The total ash of the gum was higher than that of international standard gum Arabic. Micromeritic properties indicated the need for a flow aid to improve flowability. Six formulated batches of tablets containing 0.5–5%w/w of gum, respectively, were generally soft with none passing the USP T80 standard of drug dissolution indicating poor tablet binding and drug-releasing properties. The disintegration action of CAPG was poor (only batches containing 0.5 and 1% CAPG passed) and was not comparable to that of the standard corn starch. The gum was therefore considered a poor disintegrant and binder in the formulation of conventional release tablets.

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Preliminary health risk assessment of two exudate gums as pharmaceutical excipients

et al. 2023

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Preliminary Phytochemical Evaluation and chemical Composition of Gum Isolated from Fenugreek Seeds

Abstract: BioBacta

Cited by 4 publications

References 4 publications

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Evaluation of the Physicochemical and Micromeritic Properties of Exudate Gum of Cussonia arborea Stem Bark in Conventional Tablet Formulation

Preliminary health risk assessment of two exudate gums as pharmaceutical excipients

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