Preliminary Phytochemistry and Antidiabetic Activity of Portulaca Grandiflora Hook Plant Extract on Streptozotocin-Induced Diabetes in Rats

Devi, Masilamani Sri; Komal, S; Logeshwari, B

doi:10.22159/ajpcr.2019.v12i12.35216

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…Plants having similar extracts have shown the same result. 32 Antioxidant enzymes make free radicals less harmful or ineffective. GSH is one of the antioxidant substances that prevent oxidative stress.…”

Section: Effect Of Corchorus Trilocularis Extracts On Various Pancrea...mentioning

confidence: 99%

Evaluation of Antidiabetic Activity of Corchorus trilocularis Linn Plant Extract

Omer

Vidyadhara²,

Sandeep³

2022

Int J Life Sci Pharm Res

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Diabetes is a major health issue that has been faced by the majority of the population in the world. Extensive research is being carried out towards development of an antidiabetic component. The aim of the present research was to determine the antidiabetic activity of Corchorus trilocularis Linn plant belonging to the Tiliaceae family. The objectives were to evaluate various serum and pancreatic parameters related to evaluation of diabetes. The whole plant was extracted using various solvents. Phytochemical screening was done for the extracts. Antidiabetic activity was determined using Streptozotocin (STZ) induced diabetes model in rats using 200 mg/kg and 400 mg/kg doses of various extracts. Biochemical components like glycosylated hemoglobin (HbA1c), glutathione, creatine kinase (CK) and lactate dehydrogenase (LDH) were estimated for the collected blood samples from rats. The pancreatic tissue was homogenized and the result was subjected for estimation of TBARS (thiobarbituric acid-reactive substances), catalase, superoxide dismutase (SOD) and glutathione (GSH). Phytochemical screening showed presence of carbohydrates, glycosides, alkaloids, triterpenes, phytosterols, tannins, flavonoids, saponins, mucilage and steroids. The chloroform extract at 400 mg/kg dose significantly lowered the levels of HbA1c and restored blood GSH levels. The levels of CK and LDH were increased in diabetic rats. The treatment with chloroform extract (400 mg/kg) for 21 days significantly reduced the levels of CK when compared to diabetic rats. Extent of TBARS formed was significantly higher (p<0.001) in STZ treated group. In chloroform extract (400 mg/kg) treated groups, TBARS levels have significantly decreased (p<0.001). Diabetic rats treated with chloroform extract (400 mg/kg) showed significant increase (p<0.01) in levels of SOD. GSH activity was reduced in pancreatic tissue of diabetic rats, compared to normal animals. These levels were significantly (p<0.01, p<0.001) increased with chloroform extracts (200 mg/kg and 400 mg/kg) treatment. Thus the present study showed the antidiabetic potency of Corchorus trilocularis Linn plant.

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Section: Effect Of Corchorus Trilocularis Extracts On Various Pancrea...mentioning

confidence: 99%

Evaluation of Antidiabetic Activity of Corchorus trilocularis Linn Plant Extract

Omer

Vidyadhara²,

Sandeep³

2022

Int J Life Sci Pharm Res

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“…However, vegetative propagation is preferable for its feasibility and efficiency (Cruz et al 2019). Although P. grandiflora is widely known as an ornamental plant, indepth research and exploration of the biochemical compounds of P. grandiflora have led to a piece of knowledge on the use of P. grandiflora as a medicinal plant (Lim et al 2014;Devi et al 2019).…”

Section: Introductionmentioning

confidence: 99%

The diversity of agromorphological characters of Portulaca grandiflora in the MV8 population deriving from recurrent irradiation

et al. 2022

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Abstract. Aisyah SI, Saraswati RAM, Yudha YS, Nurcholis W. 2022. The diversity of agromorphological characters of Portulaca grandiflorain the MV8 population deriving from recurrent irradiation. Biodiversitas 23: 4432-4439. A multipurpose ornamental plant, Portulaca grandiflora has the value of attractiveness and uniqueness, which lies in various agromorphological characters, primarily in flowers. The potential of P. grandiflora in qualitative characters such as new and unique shapes and colors of the morphology must be enhanced further to increase its economic and aesthetic significance as a floriculture commodity. The induced mutation technique has been proven to improve plants' morphological diversity, and even numerous novel cultivars are produced from artificial mutations. The recurrent irradiation technique was applied in the P. grandiflora mutation breeding program and produced new morphological variations of P. grandiflora until the MV7 generation (seventh generation of the mutation breeding program). The current study aimed to evaluate the diversity of morphological characters of P. grandiflora mutants in the MV8 population resulted from reccurent irradiation technique. Fifty-three selected mutants of P. grandiflora generation MV7 were multiplied by stem cuttings to create an MV8 population. The total MV8 population of P. grandiflora, the result of vegetative propagation, was 1104 plants. The diversity of morphological characters of P. grandiflora in the MV8 population was identified quantitatively (measurement) and qualitatively (visual observation). The results of this study reveal that several P. grandiflora mutants in the MV8 population have a new phenotypic appearance, chiefly in the qualitative characters of flowers. Besides, most of the P. grandiflora MV8 mutant population has inherited identical morphological characters from the previous generation (MV7 population). Further morphological analysis in the next generation needs to be conducted to evaluate the morphological stability of P. grandiflora mutants to develop new cultivars and to investigate the possibility of new phenotypic variations caused by recurrent irradiation treatments.

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“…P. grandiflora is a species of the Portulacaceae family that has been shown to have various pharmacological effects [1]. Apart from highlighting the attractiveness of its morphology, P. grandiflora has various bioactive compounds that are helpful in folk medicine and maintain the health of the body's organs [2]. Ethnobotanical reviews noted that P. grandiflora has edible leaves [3].…”

Section: Introductionmentioning

confidence: 99%

“…Yan et al [6] found that Portulacanones compounds have cytotoxic activity against human cancer cells. Besides phenolic compounds, the results of biochemical screening of P. grandiflora performed by Devi et al [2] showed the presence of other compounds such as glycosides, phytosterols, saponins, and isoprenoids. Like most medicinal plants, P. grandiflora has a significant role in warding off free radicals.…”

Section: Introductionmentioning

confidence: 99%

“…A plethora of comprehensive research on exploring and improving the biochemical compounds of P. grandiflora, particularly the polyphenol content, has been conducted [1][2][3][4][5]. However, to the best of our knowledge, no studies report the alteration of polyphenolic contents and the antioxidant capacity of P. grandiflora obtained from the gamma-ray mutation.…”

Section: Introductionmentioning

confidence: 99%

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Total phenolic, flavonoid contents, and antioxidant activity of three selected Portulaca grandiflora mutants in MV8 generation as a result of recurrent irradiation technique

Nurcholis¹,

Aisyah²,

Saraswati³

et al. 2022

J App Biol Biotech

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Portulaca grandiflora belongs to the Portulacaceae family that is cultivated as an ornamental plant. Because of the sound pharmacological and curative effects of P. grandiflora, this plant can be used as a medicinal plant. Antioxidants are one of the important properties of P. grandiflora. Recurrent irradiation method using gamma-ray can modify the plant biochemical arrangement, and the resulting changes are heritable characters. The objective of the present experiment was to evaluate the phenolic content, flavonoids, and antioxidant activity of three P. grandiflora mutated genotypes in an advanced population of MV8 (eighth generation in P. grandiflora mutation breeding program). Before the extraction process, the three genotypes were measured fresh weight and dry weight. Extraction of the three test samples of P. grandiflora using the maceration method. Analysis of total phenolics was based on the Folin-Ciocalteu method and total flavonoids using the aluminum chloride solution method. The antioxidant capacity of the three P. grandiflora genotypes was examined using the free radical 1,1-diphenyl-2-picrylhydrazyl. Fresh weight and IC 50 values of the three P. grandiflora genotypes were statistically significantly different. The antioxidant activity of P. grandiflora emanated from phenolic and flavonoid compounds. The recurrent irradiation method on P. grandiflora produced three novel genotypes that were tested to have potential antioxidant capacities that were useful for protecting the body from oxidative stress.

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Preliminary Phytochemistry and Antidiabetic Activity of Portulaca Grandiflora Hook Plant Extract on Streptozotocin-Induced Diabetes in Rats

Cited by 5 publications

References 12 publications

Evaluation of Antidiabetic Activity of Corchorus trilocularis Linn Plant Extract

Evaluation of Antidiabetic Activity of Corchorus trilocularis Linn Plant Extract

The diversity of agromorphological characters of Portulaca grandiflora in the MV8 population deriving from recurrent irradiation

Total phenolic, flavonoid contents, and antioxidant activity of three selected Portulaca grandiflora mutants in MV8 generation as a result of recurrent irradiation technique

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