Preliminary Report on L-Forms: Possible Role in the Infectious Origin of Secretory Otitis Media

Abstract

Infection and inflammation of the middle ear cleft are important factors in the pathogenesis of secretory otitis media. Although high percentages of negative cultures are confronted in many studies, strong evidence pointing to the infectious nature of this disease could not be overlooked. Many authors agree about the failure of conventional culture methods in identifying the responsible pathogen or pathogens. Besides, some agents, such as some kinds of antibiotics, lysozyme, and perhaps some undetected materials, are capable of changing bacterial behavior and consequently the clinical course. Effusions taken from 40 ears with secretory otitis media were cultured by means of conventional brain-heart infusion broth and special hypertonic thioglycollate broth. Strikingly, bacterial L-forms were detected in 6 specimens in thioglycollate broth, with no growth in the conventional broth. We concluded that these atypical forms of bacteria, the L-forms, may play an important role in the bacteriologic aspect of secretory otitis media.

Tumor necrosis factor‐α and interleukin‐1 β levels in recurrent and persistent otitis media with effusion

“…The onset and longevity of the disease are determined by several factors such as eustachian tube function, allergy, presence of bacterial components in the middle ear, frequency of upper respiratory infections, and environmental factors. [1][2][3][4][5] Most patients with OME recover well either spontaneously or with treatment. 6 However, some percentage of this population resists the medical therapy and develops chronic or frequently recurring OME and eventually develops chronic OME even though there is no obvious determining factor.…”