Preliminary Report on Neonatal Screening for Congenital Hypothyroidism, Congenital Adrenal Hyperplasia and Glucose-6-Phosphate Dehydrogenase Deficiency: A Chandigarh Experience

Kaur, Gurjit; Srivastav, Jyoti; Jain, Suksham; Chawla, Deepak; Chavan, BS; Atwal, Rajiv; Randhawa, Gurpreet; Kaur, Avneet; Prasad, Rajendra

doi:10.1007/s12098-010-0150-x

Cited by 61 publications

(41 citation statements)

References 15 publications

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“…However homozygous female with G6PDD can present clinically [18]. Kaur etal reported the incidence of G6PDD in this study was found to be 1 in 112 (0.89%) with a higher prevalence in males than females in Chandigarh, India which was true for the present study also [19].Pao M et al conducted a retrospective hospital based study among 2479 neonates and observed G6PDD incidence to be 2%. In males, incidence was 2.83 % and in females incidence was 1.05% [10].Kumar P et al performed a meta-analysis in both fixed and random effect models.…”

Section: Male To Female Ratiosupporting

confidence: 67%

Incidence, etiological risk factors and outcome of glucose-6 phosphate dehydrogenase deficiency (G6PDD) among neonates presenting with hyperbilirubinemia in tertiary care hospital, Punjab.

Singh¹,

Singh²,

Sagar³

et al. 2017

Int. J. Curr. Res. Med. Sci.

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Section: Male To Female Ratiosupporting

confidence: 67%

Incidence, etiological risk factors and outcome of glucose-6 phosphate dehydrogenase deficiency (G6PDD) among neonates presenting with hyperbilirubinemia in tertiary care hospital, Punjab.

Singh¹,

Singh²,

Sagar³

et al. 2017

Int. J. Curr. Res. Med. Sci.

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“…Devi AR and Noushad et al, [8], has taken the following range for comparison -CBTSH value < 10µ/ml as normal,10-20 µU/ml as borderline and > 20 µU/ml as abnormal. Recently,another study from India by Gurjit Kaur et al, [9] from Chandigarh has taken 9µU/ml as the TSH cutoff value. Ruth V Mikelsaar et al, [10] from Estonia have taken the TSH cut -off value for neonatal screening as 12 µU/ml,which is a still lower cut-off value as compared to our study.…”

Section: Discussionmentioning

confidence: 99%

Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India

Raj

Stephenson

George

et al. 2014

JCDR

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Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives:To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born in a rural tertiary care institution in South India. Methods:A cross-sectional study was done in 430 term neonates at birth to analyse the cord blood TSH levels and a repeat TSH estimation was done on 3 rd postnatal day for those having abnormal values. The values were statistically analysed with respect to maternal, paternal and perinatal parameters.

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“…(Foroughinia and Karimi, 2007;Kaur et al, 2010;Kuwahata et al, 2010;Parashar, 2010) was put forth. One main reason contributing to the severity of this disease is the fact that acute hemolysis can occur and that it is difficult to prevent the hemolysis caused by accidental intake of drugs.…”

Section: Introductionmentioning

confidence: 99%

Screening and prevention of neonatal glucose 6-phosphate dehydrogenase deficiency in Guangzhou, China

Jiang¹,

Li²,

Cao³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We aimed to summarize the results of screening protocol and prevention of neonatal glucose 6-phosphate dehydrogenase (G6PD) deficiency during a 22-year-long period to provide a basis of reference for the screening of this disease. About 1,705,569 newborn subjects in Guangzhou City were screened for this deficiency. Specimens were collected according to the conventional method of specimen acquisition for "newborn dried bloodspot screening", preserved, and inspected. The specimens were studied with fluorescent spot test and quantitative fluorescence assay. Diagnosis was performed using the modified NBTG6PD/6PGD ratio method. Bloodspot filter paper specimens were sent to the laboratory within 24 h via EMS Express, and the G6PD test was performed on the same day. The G6PD deficiency-positive rate was 4.2% in the samples screened using the fluorescent spot test, while it was 5% in case of the quantitative fluorescence assay. Neonatal screening for G6PD deficiency for 11,437 cases (6117 boys and 5320 girls) showed positive results in 481 cases. About 420 cases (318 boys and 102 girls) of G6PD deficiency were confirmed with the modified Duchenne NBT ratio method. The total detection rate was 3.7:5.2% for boys and 1.9% for girls. Quantitative fluorescence assay improved the sensitivity and detection rate. Accelerating the speed of sample delivery by using Internet network systems and ensuring online availability of screening results can aid the screening and diagnosis of this deficiency within 1 week of birth.

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Preliminary Report on Neonatal Screening for Congenital Hypothyroidism, Congenital Adrenal Hyperplasia and Glucose-6-Phosphate Dehydrogenase Deficiency: A Chandigarh Experience

Cited by 61 publications

References 15 publications

Incidence, etiological risk factors and outcome of glucose-6 phosphate dehydrogenase deficiency (G6PDD) among neonates presenting with hyperbilirubinemia in tertiary care hospital, Punjab.

Incidence, etiological risk factors and outcome of glucose-6 phosphate dehydrogenase deficiency (G6PDD) among neonates presenting with hyperbilirubinemia in tertiary care hospital, Punjab.

Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India

Screening and prevention of neonatal glucose 6-phosphate dehydrogenase deficiency in Guangzhou, China

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