Preliminary Report on the Experimental Induction of Metastases from a Heterologous Cancer Graft in Mice

Molomut, Norman; Spain, David M.; Gault, Sidney D.; Kreisler, L

doi:10.1073/pnas.38.11.991

Cited by 18 publications

(4 citation statements)

References 4 publications

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“…Agosin et al 102 and Molomut et al 103 have reported an increase in the incidence of metastases in cortisone-treated tumor-bearing mice. These observation could be confirmed by many authors (Table 7).…”

Section: Effect Of Hormonal Therapy On the Spreading Of Metastasesmentioning

confidence: 99%

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Mattern¹,

Büchler²,

Herr³

2007

Cancer Biology & Therapy

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ABBrevIAtIons DEX ABstrActGlucocorticoids have been widely used as cotreatment for patients with cancer due to potent pro-apoptotic properties in lymphoid cells, reduction of nausea and diminishing acute toxicity on normal tissue. There are now data from preclinical and, to some extent, clinical studies, demonstrating that these medicaments are highly suspicious to induce therapy resistance in the majority of malignant solid tumors-irrespective of tumor origin and the nature of specific anticancer drugs or irradiation used for treatment. Despite these huge amounts of data, the underlying mechanisms of cell type-specific signaling by these steroid hormones are just beginning to be described. This review summarizes our present understanding of a relationship between glucocorticoid-induced reversible cell cycle arrest and therapy resistance in solid tumors. We give a summary of our current knowledge of decreased proliferation rates in response to glucocorticoid pre and combination treatment which are suspicious to be involved not only in protection of normal tissues, but also in protection of solid tumors from cytotoxic effects of anticancer agents. The inhibition of cell cycle progression by pretreatment with GCs may be crucially involved in switching the balance of several interacting pathways to survival upon treatment with GCs.

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Section: Effect Of Hormonal Therapy On the Spreading Of Metastasesmentioning

confidence: 99%

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Mattern¹,

Büchler²,

Herr³

2007

Cancer Biology & Therapy

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“…In another interesting series of experiments. Molomut and co‐workers (12) attempted to determine what effect wounding, used as a traumatic stimulus, would have on the growth of an homologous cancer graft. Wounding consisted of opening a wound surgically each day in order to mimic the situation of continuously granulating tissue.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Molomut and co-workers (12) found that mice given lyophilized sarcoma I followed by a live implant one week later, and treated with cortisone, showed widespread metastases. No metastases developed in the control mice given lyophilized sarcoma I and then a live implant.…”

mentioning

confidence: 99%

Host‐tumor Antagonism. Xii. Possible Effect of the Cortisone Drugs on the Development of Metastases in Patients With Carcinoma†

Pelner¹

1959

J American Geriatrics Society

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“…This hormone might produce, under some conditions, the inhibition of tumor growth [13,19,27,31], and in others, tumor metastasing [1,14,18,20], heterotransplantability [28] or cancerogenesis stimulation [4,6,[23][24][25][26]. So far the mechanisms of these effects are not fully understood, requiring further studies.…”

mentioning

confidence: 99%

Studies on Tumors’ Variability

Fadei¹

1971

Oncology

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Progressive HC action on H₁₀Z zig-zag in vivo/in vitro transplanted Syrian hamster tumor is studied, and the following biological, cytological and cytogenetical modifications were obtained. (1) Giant cells and atypical mitoses, representing morphological characteristics of early experimenting stages. (2) Decrease in tumor growth and the appearance of a great chromosome number values dispersion, starting with the concentration of 275 μg/ml HC. (3) Tumor HC resistance, biologically characterized by a return to a high rate of growth and genetically by the presence of a heteroploid cell type with a new markerchromosome, by elevating HC concentration beyond 500 μ/ml. The occurrence of this tumor cell type in control tumor too, as well as its selection in later stages of the experiment only, suggest the role of induction-selection mechanism in these tumor modifications.

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Preliminary Report on the Experimental Induction of Metastases from a Heterologous Cancer Graft in Mice

Cited by 18 publications

References 4 publications

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Host‐tumor Antagonism. Xii. Possible Effect of the Cortisone Drugs on the Development of Metastases in Patients With Carcinoma†

Studies on Tumors’ Variability

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