Preliminary report on the expression of leptin and leptin receptor (ObR) in normal, hyperplastic and neoplastic canine mammary tissues

Ressel, Lorenzo; Finotello, Riccardo; Innocenti, Viola Maria; Vannozzi, Iacopo; Poli, Alessandro

doi:10.1016/j.rvsc.2011.07.020

Cited by 9 publications

(10 citation statements)

References 26 publications

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“…Although circulating leptin levels increase in obese dogs (Ishioka et al, 2007), leptin and ObR expression in MCs were not correlated with BCS, similar to the findings in a previous study (Ressel et al, 2012). The proportion of grade I tumors was higher among leptin-positive MCs than among leptin-negative MCs (P = 0.008), and a good correlation was observed with PR-positive MCs (P = 0.029).…”

Section: Discussionsupporting

confidence: 87%

“…For leptin, ObR, and adiponectin, the percentage of stained cells on each slide was calculated from five representative fields at a magnification of ×40. Evaluation of leptin and ObR expression was performed as previously described (Ressel et al, 2012). Leptin staining was considered as negative when the staining intensity of tumor cells was weaker than that of adipocytes in each slide or when <5% tumor cells were strongly stained.…”

Section: Immunohistochemical Scoringmentioning

confidence: 99%

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Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Lim

Kim

et al. 2015

The Veterinary Journal

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Section: Discussionsupporting

confidence: 87%

Section: Immunohistochemical Scoringmentioning

confidence: 99%

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Lim

Kim

et al. 2015

The Veterinary Journal

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“…31 Leptin is essential for normal mammary gland development, but it can be expressed in CMCs as well. 30 Leptin is known as one of the growth factors in breast cancer because it has mitogenic effects and affects the transformation of breast cancer cells to more aggressive phenotypes. In the current study, we confirmed that the expression of leptin was not directly associated with overweight/obesity status.…”

Section: Discussionmentioning

confidence: 99%

Effects of Obesity and Obesity-Related Molecules on Canine Mammary Gland Tumors

Lim

Kim

et al. 2015

Vet Pathol

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Obesity can affect the clinical course of a number of diseases, including breast cancer in women and mammary gland tumors in female dogs, via the secretion of various cytokines and hormones. The objective of this study was to examine the expression patterns of obesity-related molecules such as aromatase, leptin, and insulin-like growth factor 1 receptor (IGF-1 R) in canine mammary carcinomas (CMCs) on the basis of the body condition score (BCS). Comparative analyses of the expression of these molecules, together with prognostic factors for CMCs, including hormone receptors (HRs; estrogen and progesterone receptors), lymphatic invasion, central necrosis of the tumor, and histologic grade, were performed on 56 CMCs. The mean age of CMC onset was lower in the overweight or obese group (8.7 + 1.9 years) than in the lean or ideal body weight group (10.4 + 2.7 years). The proportion of poorly differentiated (grade III) tumors was significantly higher in the overweight or obese female dogs. Aromatase expression was significantly higher in the overweight or obese group and was correlated with the expression of HRs (P ¼ .025). These findings suggest that overweight or obese status might affect the development and behavior of CMCs by tumoradipocyte interactions and increased HR-related tumor growth.

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“…Adipocytes are the main site of leptin synthesis and the main contributor to the serum leptin levels, but other tissue sites have been identified that can produce leptin. In dogs, leptin, leptin receptors, or both were recently detected in the stomach, mammary tissue, myocardium, corpus luteum, and even oral melanoma, but not in the pancreas, although it remains to be determined whether these findings were dependent on the experimental methods employed. However, it has been shown that leptin and its receptors are present in the pancreas in humans and laboratory animals, and it has been suggested that leptin may also play roles in the modulation of pancreatic function, as well as being involved in pancreatitis .…”

Section: Discussionmentioning

confidence: 99%

Serum Adipokine Concentrations in Dogs with Acute Pancreatitis

Paek

Kang

Kim

et al. 2014

Veterinary Internal Medicne

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BackgroundLimited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs.ObjectivesTo determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors.AnimalsTwenty‐eight healthy dogs and 25 client‐owned dogs with AP.MethodsProspective observational cohort study of 25 client‐owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)‐1β, IL‐6, IL‐10, IL‐18, and tumor necrosis factor (TNF)‐α were measured.ResultsThe serum concentrations of leptin (P = .0021), resistin (P = .0010), visfatin (P < .0001), IL‐1β (P < .0001), IL‐6 (P = .0002), IL‐10 (P < .0001), and IL‐18 (P < .0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P = .0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P = .028) and adiponectin (P = .046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P = .037) and IL‐1β (P = .027) decreased significantly, whereas the serum concentrations of leptin (P > .999), adiponectin (P = .11), visfatin (P = .83), IL‐6 (P = .82), IL‐10 (P = .82), IL‐18 (P = .56), and TNF‐α (P = .94) did not differ significantly.Conclusion and Clinical ImportanceThis study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.

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Preliminary report on the expression of leptin and leptin receptor (ObR) in normal, hyperplastic and neoplastic canine mammary tissues

Cited by 9 publications

References 26 publications

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Effects of Obesity and Obesity-Related Molecules on Canine Mammary Gland Tumors

Serum Adipokine Concentrations in Dogs with Acute Pancreatitis

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