The Ellsworth terrane is one of a number of fault-bounded blocks that occur along the eastern margin of Ganderia, the westernmost of the peri-Gondwanan domains in the northern Appalachians that were accreted to Laurentia in the Paleozoic. Geologic relations, detrital zircon ages, and basalt geochemistry suggest that the Ellsworth terrane is part of Ganderia and not an exotic terrane. In the Penobscot Bay area of coastal Maine, the Ellsworth terrane is dominantly composed of bimodal basalt-rhyolite volcanic sequences of the Ellsworth Schist and unconformably overlying Castine Volcanics. We use new U-Pb zircon geochronology, geochemistry, and Nd and Pb isotopes for these volcanic sequences to constrain the petrogenetic history and paleotectonic setting of the Ellsworth terrane and its relationship with Ganderia.U-Pb zircon geochronology for rhyolites indicates that both the Ellsworth Schist (508.6 ± 0.8 Ma) and overlying Castine Volcanics (503.5 ± 2.5 Ma) are Middle Cambrian in age. Two tholeiitic basalt types are recognized. Type Tb-1 basalt, present as pillowed and massive lava fl ows and as sills in both units, has depleted La and Ce ([La/Nd] N = 0.53-0.87) values, fl at heavy rare earth element (REE) values, and no positive Th or negative Ta anomalies on primitive mantlenormalized diagrams. In contrast, type Tb-2 basalt, present only in the Castine Volcanics, has slightly enriched LREE ([La/Yb] N = 1.42-2.92) values and no Th or Ta anomalies. Both basalt types have strongly positive ε Nd (500) values (Tb-1 = +7.9-+8.6; Tb-2 = +5.6-+7.0) and relatively enriched Pb isotopic compositions ( 206 Pb/ 204 Pb = 18.037-19.784; 207 Pb/ 204 Pb = 15.531-15.660; 208 Pb/ 204 Pb = 37.810-38.817). The basalts have compositions transitional between recent normal and enriched midocean-ridge basalt, and they were probably derived by partial melting of compositionally heterogeneous asthenospheric mantle. Two types of rhyolite also are present. Type R-1 rhyolite, which mostly occurs as tuffs interlayered with basalt in the Ellsworth Schist, is calc-alkaline and characterized by relatively low REE, Zr, and Hf contents, enriched LREE ([La/Yb] N ~3-6), positive Th and negative Ta anomalies, ε Nd (500) values near zero (+0.5 to −0.9), and relatively unradiogenic Pb isotope values ( 206 Pb/ 204 Pb = 18.845; 207 Pb/ 204 Pb = 15.625; 208 Pb/ 204 Pb = 38.626). The data suggest that R-1 rhyolite magma was likely derived by mixing of basalt with melts from a relatively depleted crustal source. Type R-2 rhyolite, which mostly occurs as lava fl ows and domes in the Castine volcanics, is tholeiitic and characterized by enriched REE with fl at patterns ([La/Yb] N = 1-2.5), moderate negative Eu anomalies (Eu/Eu* = 0.3-0.5), enriched Th, small negative Ta anomalies, and ε Nd (500) (+5.8-+7.5) and Pb isotope ( 206 Pb/ 204 Pb = 19.175-19.619; 207 Pb/ 204 Pb = 15.605-15.649; 208 Pb/ 204 Pb = 38.834-38.851) values that overlap those of the tholeiitic basalts. The data suggest that R-2 rhyolite magma was derived by the partial melting of hydrothermally...