Preliminary results demonstrating the impact of Mediterranean diet on bone health

Savanelli, Maria Cristina; Barrea, Luigi; Macchia, Paolo Emidio; Savastano, Silvia; Falco, Andrea; Renzullo, Andrea; Scarano, E; Nettore, Immacolata Cristina; Colao, Annamaria; Somma, C. Di

doi:10.1186/s12967-017-1184-x

Cited by 63 publications

(33 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have recently reported that the dietary intake of long-chain omega-3 polyunsaturated fatty acid is positively associated with BMD at both the hip and the lumbar spine [ 15 ] as well as fish consumption [ 20 ]. Taken together, those results are consistent with studies that reflect that a dietary pattern compatible with the Mediterranean diet has positive effects over bone health parameters [ 7 , 8 , 21 ]. Thus, those results are consistent with the hypothesis that dietary factors may contribute to better bone health.…”

Section: Discussionsupporting

confidence: 92%

“…In another clinical follow-up of patients who regularly consumed olive oil over a 1-year period, bone mineral density (BMD) at lumbar vertebrae L3, L4, and the femoral neck had also improved [ 6 ]. The relation of bone health and olive oil consumption has also been evaluated by means of calcaneal quantitative ultrasound (QUS), showing that higher T-scores were positively associated with a higher consumption of extra-virgin olive oil [ 7 ]. A high consumption of fish and olive oil and low red meat intake has also been positively related to bone mass in adult women, suggesting the potential bone-preserving properties of this dietary pattern throughout adult life [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Olive Oil Consumption and Bone Microarchitecture in Spanish Women

et al. 2018

View full text Add to dashboard Cite

Olive oil has been demonstrated to enhance various cardiometabolic risk factors. However, to our knowledge, the association between olive oil intake and cortical and trabecular bone microarchitecture has never been evaluated in Spanish women. We aimed to examine the association between olive oil intake and cortical and trabecular bone microarchitecture. We analyzed 523 women aged 50 (9) year, range (23–81) year. Participants underwent dual-energy X-ray absorptiometry and peripheral quantitative computed tomography scans. Dietary intake of calcium, vitamin D, energy and olive oil (g/day) were assessed by a self-administered food frequency questionnaire (FFQ). After adjustment for potential confounding factors (calcium (mg/day), vitamin D (μg/day) energy (Kcal/day), age, body mass index (BMI) (kg/m2), menopausal status, and osteoporotic diagnosis (normal, osteopenia, or osteoporosis)), there were significant increases in volumetric bone mineral density (vBMD) (mg/cm3) (p < 0.01) in the group with a higher intake of olive oil. Total, trabecular and cortical bone density were positively correlated with olive oil intake. The dietary intake of olive oil was significantly associated with vBMD in multiple regression analysis; total density: olive oil intake (g/day) standardized β = 0.185 (p < 0.001), trabecular density: olive oil intake (g/day) standardized β = 0.186 (p < 0.001) and cortical density olive oil intake (g/day) standardized β = 0.114 (p = 0.008). We conclude that the dietary intake of olive oil is positively associated with a better vBMD in Spanish women.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Olive Oil Consumption and Bone Microarchitecture in Spanish Women

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The BIA phase-sensitive system (800 µA, 50 kHz; BIA 101 RJL, Akern Bioresearch, Florence, Italy) was used by experienced observers to assess body composition [19] as previously reported [17,[20][21][22]. We performed the exam as suggested by the European Society of Parental and Enteral Nutrition (ESPEN) [23].…”

Section: Bioelectrical Impedance Analysismentioning

confidence: 99%

Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study

et al. 2019

Self Cite

View full text Add to dashboard Cite

Growing evidence reported that vitamin D deficiency is a common finding in obesity. Vitamin D status also seems to be sex-related, although little is known regarding this association. Therefore, the aim of this study was to investigate the sex-related differences of serum 25OH vitamin D (25OHD) concentrations across body mass index (BMI) classes and, if there were any differences, whether they could be explained by sex-related differences in body composition. We enrolled 500 subjects (250 males, age 37.4 ± 11.8 years; 250 females, age 36.6 ± 11.8 years). Body composition was assessed by bioelectrical impedance analysis (BIA) phase-sensitive system. Serum 25OHD concentration was quantified by a direct, competitive chemiluminescence immunoassay. Vitamin D deficiency was defined as a serum 25OHD concentrations < 20 ng/mL (50 nmol/L). Stratifying the sample population according to sex and BMI categories, 25OHD concentrations were significantly higher in males compared to females in all BMI classes and decreased along with the increase of BMI values. Females with vitamin D deficiency had higher fat mass (FM) % compared to males with vitamin D deficiency. The 25OHD concentrations inversely correlated with FM % in both sexes. In a multiple regression analysis model, sex, FM %, and BMI were predictive factors of 25OHD concentration. In conclusion, our study suggests that 25OHD concentrations were lower in females than males across all BMI categories. Given the tight correlation between 25OHD concentrations and FM %, it can be hypothesized that the lower 25OHD concentrations in females than males can be explained by the fact that females have a higher amount of fat than males.Nutrients 2019, 11, 3034 2 of 12 coming from The National Health and Nutrition Examination Survey (NHANES) 2005 to 2006 provide information regarding the prevalence of vitamin D deficiency in people with obesity and at normal weight. The 2005 to 2006 NHANES included certain subgroups of the US population, including low-income persons, older adults aged 60 years or older, African Americans, and Mexican Americans, to provide a more in-depth snapshot of these population groups. A total of 12,862 individuals were sampled in the 2005 to 2006 NHANES. Among the sampled individuals, 10,348 (80.5%) participated in the interview and 8306 (65%) provided valid data on vitamin D measurement. The findings of this study reported that the prevalence of vitamin D deficiency (vitamin D concentration < 20 ng/mL) has been reported to be higher (53.8%) in subjects with obesity compared to normal weight (33%) [6]. Body fat may represent a reservoir for vitamin D storage, reducing its bioavailability [7]. An inverse correlation between serum 25OHD concentration and magnitude of weight loss in people with obesity after bariatric surgery confirms this theory [8]. Indeed, large accrual in adipose tissue depot implies that vitamin D3 could not be appropriately released into the general circulation to support serum 25OHD concentrations. However, the sequestration and the inappr...

show abstract

“…; Savanelli et al . ). These positive outcomes from a Mediterranean diet support wider investment in nutritional strategies and dietary change to improve health in older adults.…”

Section: Personalising Nutrition For Older Adultsmentioning

confidence: 97%

Personalising nutrition for older adults: The InCluSilver project

2018

View full text Add to dashboard Cite

Ageing is associated with a decline in health and an increase in age-related disease. However, the rate of biological ageing is not consistent between individuals and is not completely determined by genes. The rate of ageing and health decline is influenced by the environment and can be manipulated experimentally (e.g. by regulating metabolism). This highlights the potential for appropriate nutrition in order to maintain metabolic health as we age. Such interventions could consequently increase health-span and quality of life of an ageing population. However, public health advice about nutrition, such as consumption of two portions of fish each week (one of which should be oily) and eating at least five portions of fruit and vegetables daily, is focused on the population as a whole. It may not address an older individual's specific nutrient requirements to maintain health during ageing. The InCluSilver project, supported by the European Union Horizon 2020 programme, seeks to address this challenge through personalised nutrition for older adults. Personalised dietary recommendations should be fine-tuned to an individual's age, health, phenotype/genotype, activity, preferences and/or motivations, and framed by evidence from clinical trials. However, currently the dietary evidence base in older adults is small. Long-term studies that investigate dietary modifications in older individuals who are malnourished or over-nourished are needed to inform potential strategies. A wider food perspective will be necessary for successful implementation of personalised nutrition to support healthy ageing. This may include technologies that enable users to monitor their nutritional and health status for the purpose of motivating dietary adherence.

show abstract

Preliminary results demonstrating the impact of Mediterranean diet on bone health

Cited by 63 publications

References 30 publications

Olive Oil Consumption and Bone Microarchitecture in Spanish Women

Olive Oil Consumption and Bone Microarchitecture in Spanish Women

Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study

Personalising nutrition for older adults: The InCluSilver project

Contact Info

Product

Resources

About