Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine

Abstract

The present study aimed to prepare and evaluate patches for the controlled release of lidocaine/acyclovir and the binary mixture between lidocaine: acyclovir in the oral cavity. Mucoside adhesive patches containing 12.5 mg/cm2 lidocaine/acyclovir or binary mixture base were developed by a solvent casting method using sodium alginate, polyvinylpyrrolidone (PVP), glycerol (Gly), polyvinyl alcohol (PVA), and Span 80 (S). Binary mixtures between all components were prepared before the patches’ formulation in order to be able to check the substance compatibility. All formulated patches were analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). FT-IR and TGA analyses were also used to check compatibility between binary mixtures. The study establishes which membranes are indicated in the controlled release of lidocaine/acyclovir and those membranes that contain both active principles. Membranes based on alginate, PVP, and PVA can be used to release the active substance. Simultaneously, membranes with SPAN used as a gelling agent were excluded due to the interaction with the active substance. The following membranes composition have been chosen for lidocaine release: Alginate:Gly and Alginate:Gly:PVP. At the same time, the following membrane compositions were chosen for acyclovir membranes: Alginate:Gly:PVP and Alginate:PVA:Gly. Both active substances could be included to obtain a homogeneous distribution only in the membrane based on alginate, PVA, and Gly.

Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives

“…ALG is a mucoadhesive natural polysaccharide consisting of mannuronic acid and guluronic acid organized in homogeneous or heterogeneous blocks. ALG is capable of green chemical cross-linking with divalent metals and has a high water-absorption capacity, as well as desirable viscoelastic and mechanical properties [ 91 , 92 ]. ALG exhibits good mucoadhesive properties due to the presence of free carboxyl groups that can interact with mucin by hydrogen bonding.…”

Modified Potato Starch as a Potential Retardant for Prolonged Release of Lidocaine Hydrochloride from Methylcellulose Hydrophilic Gel

“…The problem of drug delivery often concentrates on retardation of drug activity [ 18 , 19 , 20 ]. The main problem is proper evaluation of release kinetics, which may reflect the bioavailability of the drug, when applied orally or topically [ 16 , 18 , 21 , 22 ]. The LH is often applied topically when painful pathological symptoms occur [ 23 ].…”

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

“…Their action can be topical [6][7][8] or systemic [9][10][11]. The variety of active ingredients contained in OF is wide: plant extracts [12][13][14][15], herbal compounds [16][17][18], nutraceuticals [19], conventional drugs [20][21][22][23][24][25][26], antibiotics [27], antivirals [28,29], vaccines [30], insulin [31], and other proteins [32].…”