Preliminary study of ovarian activity in fillies treated with a GnRH vaccine

Tshewang, Ugyen; Dowsett, K. F.; Knott, L. M.; Trigg, T. E.

doi:10.1111/j.1751-0813.1997.tb15366.x

Cited by 26 publications

(26 citation statements)

References 23 publications

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“…1). Tshewang et al (1997) reported suppressed ovarian activity (follicles ≤ 1 cm) from approximately 3–4 weeks after first immunization in all mares. The present study (Table 1) showed that the interval from the first immunization until ovarian suppression (follicles ≤ 1 cm) was observed varied between the mares and that, within the same mare, the suppression did not start at the same time in both ovaries.…”

Section: Discussionmentioning

confidence: 96%

“…It has been shown that immunization against GnRH changed the oestrous behaviour of the animals. GnRH immunization caused a cessation of oestrous cycles in rats (Fraser and Baker, 1978), gilts (Esbenshade and Britt, 1985), ewes (Jeffcoat and Keeling, 1984), mares (Garza et al, 1986; Tshewang et al, 1997) and heifers (Wettemann and Castree, 1994; Prendiville et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Only a few studies on GnRH immunization treatment have been made in mares (Garza et al, 1986; Safir et al, 1987; Tshewang et al, 1997). Garza et al (1986) and Tshewang et al (1997) reported that the ovarian activity was suppressed and that oestrous behaviour was prevented. However, in these studies only young mares were investigated (≥ 2.5 and 2 years, respectively).…”

Section: Introductionmentioning

confidence: 99%

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Immunization against GnRH in Mature Mares: Antibody Titres, Ovarian Function, Hormonal Levels and Oestrous Behaviour

Dalin

Andresen

Malmgren

2002

Journal of Veterinary Medicine Series A

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The aim of the present study was to investigate the effect of active immunization against GnRH in mature Standardbred mares (three experimental and one control mare) on antibody titres, ovarian function, hormonal levels and oestrous behaviour. The mares were individually teased with a stallion once each day. During the first part of the experiment (period I: late April until November), blood was sampled every third day during the first 3 months, thereafter once per week. In the second part of the experiment (period II: December until August), sampling was carried out every second week. Progesterone, oestradiol-17beta and LH were analysed. Rectal gynaecological examination was made with the same intervals as the blood samplings and included palpation of the genital organs and ultrasonography. The experimental mares were immunized against GnRH with a GnRH-BSA conjugate. Equimune (Vetrepharm, Bracetown, Business Park, Clonee, Co. Meath, Republic of Ireland) was used as adjuvant. The mares were immunized on four occasions (20-30 day intervals) and GnRH antibody titre was determined. All immunized mares produced antibodies against GnRH but the maximum titres as well as the duration of a greater than 10% binding capacity varied between the mares (1 : 1600 to 1 : 50 000; 5 to 12 months, respectively). After the first injection, all mares showed one oestrus and ovulated at the regular time. In two of the mares, the immunization resulted in ovarian atrophy. Their hormone levels of progesterone, oestradiol- 17beta and progesterone decreased to basal levels and the cyclical hormone pattern was interrupted from approximately 30 days onwards. They continued to show oestrous signs but with irregular durations and intervals. The third mare showed ovarian suppression only for short periods and not in both ovaries at the same time; the hormone levels were basal for only about 20 days (days 50-70) and the mare ovulated on day 75 after start of immunization. The other mares ovulated after 13.5 and 15 months, respectively. It is concluded that the effect of immunization against GnRH in mature mares was individual concerning antibody titre response and the suppression of ovarian activity and hormone levels. Mares with totally inactive ovaries continued to show oestrous signs but with irregular intervals and durations.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunization against GnRH in Mature Mares: Antibody Titres, Ovarian Function, Hormonal Levels and Oestrous Behaviour

Dalin

Andresen

Malmgren

2002

Journal of Veterinary Medicine Series A

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“…Several studies investigating the effect of GnRH vaccination have been carried out on mares, some documenting effective suppression of ovarian function and oestrous behaviour along with a subsequent reversal of these effects (Tshewang et al 1997), while others documented greater individual variation and a less reliable result (Dalin et al 2002).…”

Section: Immunization Against Gnrhmentioning

confidence: 99%

Managing a mare for breeding and sport

Burger¹,

Wohlfender²,

Imboden³

2008

PHK

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SummaryNowadays in many horse breeds a successful sporting career is required to make a horse eligible for breeding purposes, this may happen before or during its use at stud. For mares, this means careful planning and optimal management of behavioural and reproductive health, especially with the advent of affordable embryo transfer options that allow exploitation of a mare's reproductive potential without a significant break in her career. Unfortunately, there exist as yet only a few research studies in this field. This review article gives a short overview of the actual state of knowledge and the management options for mares, including behavioural management and control of reproductive function through physical, pharmaceutical or immunological means, as well as management of the mare for simultaneous use in breeding and sport.

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“…It comprises a peptide-protein conjugate and the Iscom-related immunostimulating complex adjuvant. This formulation is an advance over other commercial formulations trialed in mares and stallions that were reactogenic (50,178).…”

Section: Vaccines Against Reproductive Hormonesmentioning

confidence: 98%

Current Status of Veterinary Vaccines

et al. 2007

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SUMMARY The major goals of veterinary vaccines are to improve the health and welfare of companion animals, increase production of livestock in a cost-effective manner, and prevent animal-to-human transmission from both domestic animals and wildlife. These diverse aims have led to different approaches to the development of veterinary vaccines from crude but effective whole-pathogen preparations to molecularly defined subunit vaccines, genetically engineered organisms or chimeras, vectored antigen formulations, and naked DNA injections. The final successful outcome of vaccine research and development is the generation of a product that will be available in the marketplace or that will be used in the field to achieve desired outcomes. As detailed in this review, successful veterinary vaccines have been produced against viral, bacterial, protozoal, and multicellular pathogens, which in many ways have led the field in the application and adaptation of novel technologies. These veterinary vaccines have had, and continue to have, a major impact not only on animal health and production but also on human health through increasing safe food supplies and preventing animal-to-human transmission of infectious diseases. The continued interaction between animals and human researchers and health professionals will be of major importance for adapting new technologies, providing animal models of disease, and confronting new and emerging infectious diseases.

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Preliminary study of ovarian activity in fillies treated with a GnRH vaccine

Abstract: Both dose rates suppressed ovarian function and prevented oestrous behaviour. These effects were reversible and the subsequent fertility of the vaccinated fillies was normal.

Cited by 26 publications

References 23 publications

Immunization against GnRH in Mature Mares: Antibody Titres, Ovarian Function, Hormonal Levels and Oestrous Behaviour

Immunization against GnRH in Mature Mares: Antibody Titres, Ovarian Function, Hormonal Levels and Oestrous Behaviour

Managing a mare for breeding and sport

Current Status of Veterinary Vaccines

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