Preliminary study of the frequency ofbenign prostatic hyperplasia and prostatic cancer in China

Gu, Fangyi; Xia, Tongli; Kong, Xiangbin

doi:10.1016/s0090-4295(94)80207-6

Cited by 70 publications

(47 citation statements)

References 2 publications

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“…In this study, we found that the frequency of incidental PCa in China was 3.3%, similar to the frequency in Lee et al [10] and Yumura et al [7] studies (4% and 5.1%, respec tively), but was much lower than the frequency in other series of RCP cases (14% to 60%) [19] and the ageadjusted frequency of autopsy-detected PCa in China [4].…”

Section: Discussionsupporting

confidence: 85%

“…In autopsy studies, the prevalence of PCa in America was 33% in men aged 60-69 years and 46% in men aged 71-80 years [3]. Autopsy studies conducted in China revealed that the rate of incidental PCa in men who were 51-69 years of age was only 9.3% and that for men who were > 70 years of age was 25% [4]. Therefore, the incidence of PCa in RCP specimens in Asia is also probably much lower than that in the Western countries.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Zhu¹,

Ye²,

Yao³

et al. 2008

Asian J Androl

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The purpose of this study is to investigate the frequency of prostate cancer (Pca) discovered incidentally in radical cystoprostatectomy specimens in Asia and to determine the feasibility of prostate-sparing cystectomy (PSC) for Asian patients. Ninety-two male bladder cancer patients who underwent radical cystoprostatectomy at our center between January 2003 and January 2008 were included in this study. The mean age of patients was 67.1 years (range: 32-75 years). Prostate-specific antigen (PSA) levels and digital rectal examination (DRE) results before surgery were obtained retrospectively. Prostates of all patients were embedded and sectioned at 5-mm intervals. The same pathologist examined the prostatic tissues from radical cystoprostatectomy specimens. Finally, a structured literature review was performed using MEDLINE and PUBMED to estimate the occurrence of incidental Pca in Asia. Of the 92 patients, 3 (3.3%) were found to have Pca; in one out of three (33.3%) patients the disease was clinically significant due to a Gleason grade 4 carcinoma. Eight articles were included in our review. The overall incidence of Pca discovered incidentally in radical cystoprostatectomy specimens in Asia was 9.9% (64/642). When age was restricted to < 60 years, only 7 out of 222 (3.2%) patients were found to have synchronous Pca, and none of the cases was clinically significant. The occurrence of Pca in radical cystoprostatectomy specimens in Asia is much lower than that in Western countries. PSC might be feasible for Asian patients under a strict preoperative selection.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Zhu¹,

Ye²,

Yao³

et al. 2008

Asian J Androl

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show abstract

“…Histological enlargement of the prostate generally initiates around 40 years of age and LUTS occurs at over fifty-five years of age. The LUTS become more severe with increasing age, which greatly impacts the quality of life of aged men (Berry et al, 1984;Gu et al, 1994). Eventually, patients must have surgery to relieve the urinary obstruction.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese

Gao

Wang

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917, and IL-28Rα rs10903035 and rs11249006 polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay. For rs10903035, the frequencies of the "G" allele and the "AG/ GG" genotypes in the LUTS group were significantly lower than those in the control group ("G" vs "A": OR = 0.655, 95%CI = 0.506-0.849; Association of the IL-28B receptor gene with LUTS AG/GG vs "AA": OR = 0.538, 95%CI = 0.379-0.764, respectively). Combined effects analysis of rs12979860 and rs10903035 showed that the "CC+AG/GG" and "CT+AA" genotypes were significantly less frequent in the LUTS group ("CC+AG/GG" vs "CC+AA": OR = 0.553, 95%CI = 0.381-0.801; "CT+AG/GG" vs "CC+AA": OR = 0.429, respectively). In addition, the combined effects of the rs8099917 and rs10903035 "TT+AG/GG" and "GT+AG/GG" genotypes were also significantly lower in the LUTS group ("TT+AG/GG" vs "TT+AA": OR = 0.569, 95%CI = 0.395-0.821; "GT+AG/GG" vs "TT+AA": OR = 0.318, 95%CI = 0.128-0.788, respectively). Stratification analysis revealed that the frequencies of the rs11249006 "AG/GG" genotypes in the subgroups of size ≤4.11 and IPSS ≤ 28 were significantly higher than those in the subgroups of size >4.11 and IPSS > 28. Therefore, the IL-28Rα gene polymorphism might be involved in the development of LUTS.

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“…Atlhough autopsy data have indicated that latent prostate cancers are only slightly less common in China than in the United States, clinically signi®cant prostate cancer is 20-fold less common in China than in the United States [1,3]. In addition, migrants from countries with low prostate cancer rates (i.e., Japan) to countries with high rates (i.e., the United States) tend to develop prostate cancer at higher rates than their countrymen who did not migrate [4], suggesting that environmental factors may underlie the East-West differences in prostate cancer progression.…”

Section: Introductionmentioning

confidence: 99%

Low-dose genistein induces cyclin-dependent kinase inhibitors and G1 cell-cycle arrest in human prostate cancer cells

et al. 2000

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Preliminary study of the frequency ofbenign prostatic hyperplasia and prostatic cancer in China

Cited by 70 publications

References 2 publications

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese

Low-dose genistein induces cyclin-dependent kinase inhibitors and G1 cell-cycle arrest in human prostate cancer cells

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