2018
DOI: 10.1089/mdr.2018.0051
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Preliminary Study on the Antibacterial Activity of Essential Oils Alone and in Combination with Gentamicin Against Extended-Spectrum β-Lactamase-Producing and New Delhi Metallo-β-Lactamase-1-Producing Klebsiella pneumoniae Isolates

Abstract: Because of their synergistic activity with gentamicin, peppermint, and caraway oils in particular, can be considered as an alternative or an addition for the control of infections with limited therapeutic options due to multidrug resistance.

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Cited by 22 publications
(27 citation statements)
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“…Combinations of LEO and OCT against MRSA strains were tested by using a previously described checkerboard method [44]. Using the known density of the LEO, the final result was expressed in mg/mL.…”
Section: Checkerboard Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Combinations of LEO and OCT against MRSA strains were tested by using a previously described checkerboard method [44]. Using the known density of the LEO, the final result was expressed in mg/mL.…”
Section: Checkerboard Methodsmentioning
confidence: 99%
“…The MIC of LEO or OCT was determined by the broth microdilution method according to the Clinical and Laboratory Standards Institute with a slight modification as described previously [44]. To exclude an inhibitory effect of both Tween 80 and DMSO, the control assays with MHB and MHB supplemented with Tween 80 (1%, v/v) or DMSO (2%, v/v) were performed.…”
Section: Determination Of Minimum Inhibitory Concentration (Mic) and mentioning
confidence: 99%
“…Mahboubi and Bidgoli [ 18 ] found a synergistic effect of Zataria multiflora EO in combination with vancomycin against S. aureus strains isolated from infection sites. On the other hand, our previous studies also indicated that peppermint and caraway EOs revealed synergistic activity against gentamicin-intermediate (producing extended-spectrum β-lactamase (ESBL) and New Delhi metallo-β-lactamase-1 (NDM-1)) and gentamicin-resistant (producing ESBL) Klebsiella pneumoniae strains, respectively [ 19 ]. Furthermore, Uzair et al [ 20 ] demonstrated that Origanum vulgare and Mentha pulgeium EOs showed effective synergistic activity in combination with amoxicillin against MRSA strains.…”
Section: Discussionmentioning
confidence: 99%
“…There are many well-known EOs that have proven bactericidal and fungicidal properties. In the era of widespread interest in the topic of ineffectiveness of antibiotic therapy and antibiotic resistance of microorganisms, EOs can naturally replace some antibiotics or become their synergistic supplement (Kwiatkowski et al 2018). Espiecially hope bringing are the results from studies, in which sensitivity of penicillin-sensitive and penicillin-resistant Streptococcus pneumoniae strains to EOs has been demonstrated (Inouye et al 2001).…”
Section: Discussionmentioning
confidence: 99%