Preliminary study on the central nervous system depressant effect of Picrorhiza kurrooa Royle. (Scrophulariaceae) in mice models

Abstract

SUMMARYPicrorhiza kurrooa Royle. is a well known medicinal plant among the indigenous medical practitioners of India. Present study is the first time to report the activity on the central nervous system. Preliminary study of the hot water extract showed significant depressant activity on the hole board test as evidenced from the ambulation and head dipping scores. The extract showed better activity compared to diazepam on the duration of pentobarbital induced sleeping time.