Preliminary Study on the Therapeutic Effect of Doxorubicin-Loaded Targeting Nanoparticles on Glioma

Abstract

Doxorubicin (DOX) is an anthracycline anticancer drug, which is often associated with drug resistance and cytotoxicity. More unfortunately, the biological barrier in the human environment can weaken the efficacy of DOX, such as the blood-brain barrier (BBB). This work attempts to make efforts to solve this problem. We used polyethylene glycol distearoylphosphatidylethanolamine (PEG-DSPE) as a nanocarrier and DOX as a model drug to construct a composite nanodrug (TF-PEG-DSPE/DOX NPs) by coupling transferrin (TF). The results of glioma experiments show that the nanodrug can effectively penetrate BBB to achieve an antitumor effect.

Tumor-Derived Membrane Vesicles Restrain Migration in Gliomas By Altering Collective Polarization

“…Additionally, mechano-signaling elements function in close association with the intercellular junction proteins, which can influence the penetration of drugs across cell layers. To probe the impact of CMV-induced changes on the efficiency of drug delivery within glioma spheroids we used doxorubicin, a commonly used antitumor drug against high grade gliomas. , …”

“…To probe the impact of CMV-induced changes on the efficiency of drug delivery within glioma spheroids we used doxorubicin, a commonly used antitumor drug against high grade gliomas. 30,31…”

Retracted: Preliminary Study on the Therapeutic Effect of Doxorubicin-Loaded Targeting Nanoparticles on Glioma

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”