Preliminary study to explore gene-PM2.5 interactive effects on respiratory system in traffic policemen

Abstract

International Journal of Occupational Medicine and Environmental (PM) is one of the major sources of air pollution in metropolitan areas. This study is to observe the interactive effects of gene and fine particles (particles smaller than 2.5 μm -PM 2.5 ) on the respiratory system and explore the mechanisms linking PM 2.5 and pulmonary injury. Material and Methods: The participants include 110 traffic policemen and 101 common populations in Shanghai, China. Continuous 24 h individual-level PM 2.5 is detected and the pulmonary function, high-sensitivity C-reactive protein (hs-CRP), Clara cell protein 16 (CC16) and the polymorphism in CXCL3, NME7 and C5 genes are determined. The multiple linear regression method is used to analyze the association between PM 2.5 and health effects. Meanwhile, the interactive effects of gene and PM 2.5 on lung function are analyzed. Results: The individual PM 2.5 exposure for traffic policemen was higher than that in the common population whereas the forced expiratory volume in 1 s (FEV 1 ), the ratio of FEV 1 to forced vital capacity (FEV 1 /FVC) and lymphocytes are lower. In contrast, the hs-CRP level is higher. In the adjusted analysis, PM 2.5 exposure was associated with the decrease in lymphocytes and the increase in hs-CRP. The allele frequencies for NME7 and C5 have significant differences between FEV 1 /FVC ≤ 70% and FEV 1 /FVC > 70% participants. The results didn't find the interaction effects of gene and PM 2.5 on FEV 1 /FVC in all the 3 genes. Conclusions: The results indicated that traffic exposure to high levels of PM 2.5 was associated with systemic inflammatory response and respiratory injury. Traffic policemen represent a high risk group suffering from the respiratory injury.

PM2.5 induces apoptosis, oxidative stress injury and melanin metabolic disorder in human melanocytes

“…Intrinsic defects within melanocytes can activate the cellular oxidative stress response (25). PM2.5 is known for its toxic effects on skin, cardiovascular and respiration systems (6,9,11). However, to the best of the authors' knowledge, the effects and mechanisms of PM2.5 on vitiligo are not fully elucidated.…”

“…It is well known to contribute to air pollution and is closely associated with human health problems (4,5). Previous epidemiological studies have demonstrated that PM2.5 was associated with the increasing prevalence and mortality rates of respiratory and cardiovascular diseases (6)(7)(8)(9)(10). In addition, a previous study identified that PM2.5 was a crucial risk factor for skin diseases and skin aging (11).…”

Personal exposure to fine particulate matter, lung function and serum club cell secretory protein (Clara)

“…Airborne particulate matter with an aerodynamic diameter of 2.5 µm or less (PM 2.5 ) can travel deeply into the respiratory tract and reach the lung. A substantial body of environmental epidemiological evidence has shown that ambient exposure to PM 2.5 , over the longterm (years) and short-term (hours to days), is associated with a range of adverse pulmonary events (Fuertes et al, 2015;Gauderman et al, 2004;Kariisa et al, 2015;Lee et al, 2007;Moshammer et al, 2006;Mu et al, 2014;Ni et al, 2016;Rice et al, 2016;Zhao et al, 2015). However, there are two major limitations on these studies.…”

“…First, the subjects of most these studies are restricted to vulnerable populations, such as children (Moshammer et al, 2006;Rice et al, 2016), adolescents (Fuertes et al, 2015;Gauderman et al, 2004), elderly people (Lee et al, 2007), patients with pulmonary diseases, (i.e., chronic obstructive pulmonary disease) (Kariisa et al, 2015;Ni et al, 2016) or population with high occupational exposure (i.e., traffic policemen) (Zhao et al, 2015). However, studies focusing on young adults who are the major labor force are extremely limited.…”

Study on multivariate regression model of indoor and outdoor particulate pollution in severe cold area of China

“…Human inhalable particulate matter (PM 10 , PM 2.5 ) is the primary pollutant in most cities in China, especially for fine particulate matter (PM 2.5 ). More and more epidemiologists show that there is a positive correlation between human morbidity, mortality and mass concentration of particulate matter (Dockery et al 1993;Zhao et al 2015;Tseng et al 2015;Cohen et al 2017;Klemm R J et al 1996). People spend 90% of their time indoors, so indoor air quality plays an important role in human health.…”