Premalignant changes associated chronic gastritis in Karbala Province: multi institutional study

Abstract

Objectives: The aim of this study was to investigate the prevalence of gastric premalignant changes as gastric atrophy, intestinal metaplasia and dysplastic changes in patients underwent esophagogastroduodenoscopy in three health institutions in Karbala province.
 Methods: The data was collected from patients attended the endoscopy units during a period from January to September 2018 in three medical centers in holy Karbala/ Iraq, Al Hussein teaching hospital, Imam Zain Al Abedin hospital and Imam AL Hujjah hospital. It includes 215 males and 285 females who were subjected to esophagogastroduodenoscopy (EGD) from whom mucosal biopsies were taken. These biopsies were stained by Giemsa to detect H. pylori organisms.
 Results: The mean age of patients was (40.9 +/- 15 years SD). H. Pylori infection was demonstrated in (71%) patients, (19.4%) were presented with glandular atrophy, (7.4%) out of 500 patients had intestinal metaplasia and only 6 (1.2%) patients had dysplastic changes. there was a significant statistical relation between gastric glandular atrophy and age, p value (0.03). there was a significant statistical relation between glandular atrophy and infection with H. Pylori, p value (0.001). there was a significant negative relation between H. Pylori infection and the existence of intestinal metaplasia, p value (0.0001). this study show a significant statistical relationship between the existence of intestinal metaplasia and the occurrence of dysplastic changes, P value (0.001).
 Conclusion: the current study show a significant relation between aging and the existence of gastric glandular atrophy. There was a significant relation between each of gastric glandular atrophy and intestinal metaplastic changes with the H. pylori infection. there was a significant relation between gastric intestinal metaplasia and dysplastic changes.

Expression Levels of the CA9, WT1, and PRAME Genes and Genotyping-Associated Antigens for the Diagnosis and Prognosis of Colorectal Cancer

“…The incidence of CRC is increasing annually worldwide. The demographics of the CRC group were similar to those of the patients in most of the studies conducted in Iraq, such as those by Radhi et al 20 in Al-Diwaniyah, by Alsafi et al 21 in Karbala, by Alshewered and Al-Naqqash 2 and by Alrubaia et al 3 in Baghdad, but differed from the demographics found in the studies by Alhilfi et al 4 in Misan, and by Khalil et al 22 in Duhok. In Western countries, 8% of the CRC cases are recorded in patients younger than 40 years of age, whereas in Asia and Africa the rates range between 15% and 35% for the same age group.…”