2012
DOI: 10.1016/j.aller.2011.09.007
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Premenstrual asthma and leukotriene variations in the menstrual cycle

Abstract: Our data show that leukotriene C4 does not appear to be involved in the pathogenesis of premenstrual asthma, or support the use of anti-leukotrienes in the specific treatment of premenstrual asthma, at least in women with a moderate premenstrual deterioration. No differences appeared in any of the categories of asthma severity.

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Cited by 5 publications
(6 citation statements)
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“…Leukotriene receptor antagonists exert a combined anti-inflammatory and bronchodilating effect [ 14 ] and are considered an adjuvant therapy for asthma exacerbations, according to a GINA statement [ 2 ]. Women with PMA exhibit significantly higher levels of serum leukotrienes in the premenstrual phase than in preovulatory, while no differences in serum leukotriene concentrations occur in asthmatic women without PMA [ 15 ].…”
Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning
confidence: 99%
See 2 more Smart Citations
“…Leukotriene receptor antagonists exert a combined anti-inflammatory and bronchodilating effect [ 14 ] and are considered an adjuvant therapy for asthma exacerbations, according to a GINA statement [ 2 ]. Women with PMA exhibit significantly higher levels of serum leukotrienes in the premenstrual phase than in preovulatory, while no differences in serum leukotriene concentrations occur in asthmatic women without PMA [ 15 ].…”
Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning
confidence: 99%
“…Pasaoglu et al obtained similar results in women with mild PMA who received montelukast, observing the absence of this beneficial effect in asthmatic women without PMA [ 221 ]. Conversely, Pereira-Vega et al analyzed serum leukotriene variations in women with and without moderate PMA, finding no differences in leukotriene levels between the preovulatory and premenstrual phases in these groups, and, therefore, not supporting an involvement of leukotrienes in the pathogenesis of moderate perimenstrual asthma [ 14 ].…”
Section: Perspective Strategies In Perimenstrual Asthma Treatmentmentioning
confidence: 99%
See 1 more Smart Citation
“…According to GINA (Global Initiative for Asthma) guidelines, contraceptive pills and/or leukotriene receptors, antagonists may be useful (evidence D) in the prevention and treatment of PMA [ 75 , 85 ]. Currently, additional hormonal therapies such as estrogens, progestogens, gonadotropin-releasing hormone (GnRH) analogues and androgens are taken into consideration [ 5 , 86 , 87 , 88 , 89 ].…”
Section: Introductionmentioning
confidence: 99%
“…Up to 40% of asthmatic women of childbearing age have PMA [7]. Hormonal therapies, leukotriene receptor antagonists, and microbially-targeted therapies have all been recommended as potential remedies for the condition [8][9][10][11][12][13][14][15][16][17]. Adolescent PMA is poorly understood, and there is no clear protocol for treating the condition.…”
Section: …………………………………………………………………………………………………… Introduction:-mentioning
confidence: 99%