Prenatal Expression Patterns of Genes Associated With Neuropsychiatric Disorders

Birnbaum, Rebecca; Jaffe, Andrew E.; Hyde, Thomas M.; Kleinman, Joel E.; Weinberger, Daniel R.

doi:10.1176/appi.ajp.2014.13111452

Cited by 99 publications

(93 citation statements)

References 38 publications

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“…15). We also found that several genes involved in neurodevelopmental disorders 32,33 had increasing A-to-I editing patterns (Supplementary Table 12).…”

Section: Functional Implications Of Increasing A-to-i Editing Patternmentioning

confidence: 70%

Dynamic regulation of RNA editing in human brain development and disease

et al. 2016

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RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rates during cortical development: stable high, stable low and increasing. RNA secondary structure and the temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to cis- and trans-regulatory mechanisms of these RNA editing patterns, respectively. Interestingly, the increasing pattern was associated with neuronal maturation, correlated with mRNA abundance and potentially influenced miRNA binding energy. Gene ontology analyses implicated the increasing pattern in vesicle or organelle membrane-related genes and glutamate signaling pathways. We also found that the increasing pattern was selectively perturbed in spinal cord injury and glioblastoma. Our findings reveal global and dynamic aspects of RNA editing in brain, providing new insight into epitranscriptional regulation of sequence diversity.

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“…15). We also found that several genes involved in neurodevelopmental disorders 32,33 had increasing A-to-I editing patterns (Supplementary Table 12).…”

Section: Functional Implications Of Increasing A-to-i Editing Patternmentioning

confidence: 70%

Dynamic regulation of RNA editing in human brain development and disease

et al. 2016

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“…Increasing numbers of recent studies have associated specific genes with neurodevelopmental disorders, intellectual disability and autism spectrum disorders (Birnbaum et al 2014;Corvin 2010). These range from genes for different signaling cascades, to apoptosis pathways and synaptic plasticity (Zeidán-Chuliá et al 2014).…”

Section: Potential Biomarkers In Autismmentioning

confidence: 99%

Are Molecules Involved in Neuritogenesis and Axon Guidance Related to Autism Pathogenesis?

et al. 2015

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Autism spectrum disorder is a heterogeneous disease, and numerous alterations of gene expression come into play to attempt to explain potential molecular and pathophysiological causes. Abnormalities of brain development and connectivity associated with alterations in cytoskeletal rearrangement, neuritogenesis and elongation of axons and dendrites might represent or contribute to the structural basis of autism pathology. Slit/Robo signaling regulates cytoskeletal remodeling related to axonal and dendritic branching. Components of its signaling pathway (ABL and Cdc42) are suspected to be molecular bases of alterations of normal development. The present review describes the most important mechanisms underlying neuritogenesis, axon pathfinding and the role of GTPases in neurite outgrowth, with special emphasis on alterations associated with autism spectrum disorders. On the basis of analysis of publicly available microarray data, potential biomarkers of autism are discussed.

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“…Autism related genes are preferentially expressed prenatally in the frontal cortex suggesting that an inherent genetic susceptibility may be confined to this period [6] . Many of these compounds are endocrine disruptors which have been linked to a variety of diseases, including autism, attention hyperactivity deficit disorder, obesity and diabetes, whose incidence has increased in recent decades.…”

Section: Introductionmentioning

confidence: 99%