Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort

Olesen, Trine Staak; Bleses, Dorthe; Andersen, Helle Raun; Grandjean, Philippe; Frederiksen, Hanne; Trecca, Fabio; Bilenberg, Niels; Kyhl, Henriette Boye; Dalsager, Louise; Jensen, Inge Kjær; Andersson, Anna‐Maria; Jensen, Tina Kold

doi:10.1016/j.ntt.2017.11.004

Cited by 44 publications

(34 citation statements)

References 55 publications

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“…Finally, we measured mono-benzyl phthalate (MBzP) and monoethyl phthalate (MEP). Moderate to high correlation between all summed metabolites has been shown elsewhere [23]. Preparation and storage of standard solutions and samples, instrumental LC-MS/MS analysis and general method validation has previously been described [22].…”

Section: Phthalate Metabolite Measurementsmentioning

confidence: 92%

“…Likewise, the 4 measured DiNP metabolites; mono-iso-nonyl phthalate (MiNP), monohydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP) and mono-carboxy-iso-octyl phthalate (MCiOP) were measured and summed as ΣDiNP m . We measured mono-iso-butyl phthalate (MiBP) and mono-nbutyl phthalate (MnBP) and combined them as MBP i + n , since the two metabolites have been shown to be highly correlated in the urine of the women of Odense Child Cohort [22,23]. Finally, we measured mono-benzyl phthalate (MBzP) and monoethyl phthalate (MEP).…”

Section: Phthalate Metabolite Measurementsmentioning

confidence: 99%

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Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

et al. 2020

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Background: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. Methods: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. Results: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ΣDiNP m and di-2-ethylhexyl phthalate metabolite (ΣDEHP m) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ΣDiNP m was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). Conclusion: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.

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Section: Phthalate Metabolite Measurementsmentioning

confidence: 92%

Section: Phthalate Metabolite Measurementsmentioning

confidence: 99%

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

et al. 2020

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“…Importantly, the relationship between BPA exposure and language development as an independent outcome and not a part of IQ has not been previously assessed. In a previous study among 518 mother-child pairs from the Odense Child Cohort, we found associations between higher maternal phthalate exposure and poorer language development in 20-36 months old boys, whereas no association was found in girls (Olesen et al 2018). We therefore wanted to explore if this association was also found for prenatal BPA exposure.…”

Section: Introductionmentioning

confidence: 91%

Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort

Jensen

Mustieles

Bleses

et al. 2019

Environmental Research

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Bisphenol A (BPA) is a non-persistent chemical with endocrine disrupting abilities widely used in a variety of consumer products. The fetal brain is particularly sensitive to chemical exposures due to its rapid growth and complexity. Some studies have reported associations between maternal BPA exposure and behaviour but few have assessed impact on cognitive development, and to our knowledge no studies have specifically assessed the impact on language development. We therefore assessed whether maternal urinary BPA concentration during pregnancy was associated with language development and attention-deficit and hyperactivity disorder (ADHD) symptoms in offspring aged 18-36 months in the prospective Odense Child Cohort. BPA was analysed in 3rd trimester maternal fasting urine spot samples. Language development was addressed among 535 children using the Danish adaptation of the MacArthur-Bates Communicative Development Inventories at median age 21 months; ADHD traits were assessed by parents of 658 children using the Child Behavior Checklist for ages 1½-5 years at mean age 2.7 years. Associations were assessed using logistic regression models comparing children below the 15th percentile score for language and above the 85 percentiles score with the other children for ADHD while stratifying by sex and adjusting for maternal education, duration of breastfeeding, and maternal urine phthalates. BPA was detected in 85.3% of the urine samples (median 1.2 ng/ml). Boys of mothers with BPA exposure in the highest tertile had an odds ratio of 3.70 (95% CI 1.34-10.21) of being in the lowest 15 th percentile of vocabulary score compared to boys of mothers within the lowest tertile after adjustment, whereas no association was found in girls. No clear dose-response relationship between maternal BPA and ADHD scores above the 85 th percentile was found for either sex. Since early language development is a relevant predictor of reading skills and educational success, more epidemiological studies assessing BPA exposure and language skills are needed to confirm our findings.

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“…Both animal studies and epidemiology have linked phthalates to the developmental neurotoxicity of DEHP (see for instance [133,134]). Regarding DBP, in adults, a recent experiment reported a possible disruption of the thyroid axis in men following DBP exposure [103].…”

Section: Phthalatesmentioning

confidence: 99%

Mikroplastik: vom Tiegel auf den Teller

Saha¹

2021

Dtsch Dermatolog

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This study, commissioned by the PETI Committee of the European Parliament, presents the scientific knowledge regarding the health effects of endocrine disruptors, a class of hazards recognized in EU regulation since 1999. This report reviews the scientific evidence regarding the concept of endocrine disruption, the extent of exposure, associated health effects and costs. The existing relevant EU regulations are discussed and recommendations made to better protect human health. ABOUT THE PUBLICATIONThis research paper was requested by the European Parliament's Committee on Petitions and commissioned, overseen and published by the Policy Department for Citizen's Rights and Constitutional Affairs.Policy Departments provide independent expertise, both in-house and externally, to support European Parliament committees and other parliamentary bodies in shaping legislation and exercising democratic scrutiny over EU external and internal policies.

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Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort

Cited by 44 publications

References 55 publications

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort

Mikroplastik: vom Tiegel auf den Teller

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