Prenatal plus postnatal exposures to phthalates and child health risks

Latini, Giuseppe; Massaro, Marika; Mandich, Anne M.

doi:10.4081/jbr.2011.4493

Cited by 1 publication

(1 citation statement)

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“…In particular it was observed that exposure to the “alternative chemicals” was increasing while the exposure to the original compounds was lowered [ 45 , 47 , 49 , 50 ]. The questionnaire allowed us to highlight some of the possible common sources of exposure to phthalates in everyday life, particularly the use of plastic containers for the storage of fat foods and eating canned foods [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Temporal Trends of Urinary Phthalate Concentrations in Two Populations: Effects of REACH Authorization after Five Years

Tranfo

Caporossi

Pigini

et al. 2018

IJERPH

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Phthalates are widely used in the industrial manufacture of many products. Some phthalates have shown reproductive toxicity in humans, acting as endocrine disruptors, so they were included in the authorization process defined in Reg. CE 1907/2006 (REACH). Two groups of population were recruited, before and after the inclusion of some phthalates in the authorization list in REACH: the first group of 157 volunteers was studied in 2011 and the second, 171 volunteers, in 2016. Each subject completed a questionnaire about personal lifestyle, working activities and use of chemical products. The main urinary metabolites of five phthalates were analyzed by HPLC/MS/MS: mono(2-ethylhexyl)phthalate (MEHP) and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) for di(2-ethylhexyl)phthalate (DEHP) exposure; monoethylphthalate (MEP) for diethylphtahate (DEP); monobenzylphthalate (MBzP) for butylbenzylphtahalate (BBP) and dibenzylphthalate (DBzP), mono-n-butylphthalate (MnBP) for butylbenzylphtahalate (BBP) and di-n-butylphthalate (DnBP). The results show a significant difference for all metabolites between the two periods, with the exception of MEP in women. The comparison of the two sets of results shows a decrease in urinary metabolites excretion from 2011 to 2016, statistically significant for the three phthalates included in Annex XIV of REACH. DEP, not currently included in the list for authorization, maintains a constant presence in the daily life of the population, particularly for women.

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