Prenatal Radiation Exposure: Background Material for Counseling Pregnant Patients Following Exposure to Radiation

Donnelly, Elizabeth H.; Smith, James M.; Farfán, Eduardo B.; Özcan, İbrahim

doi:10.1001/dmp.2011.2

Cited by 31 publications

(4 citation statements)

References 10 publications

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“…The risk is highest in the first trimester and decreases considerably in subsequent trimesters. [8][9][10] Unless there is an urgent need, RT should be postponed to the postpartum period. MTP is justifiable only if fetal dose estimates exceed 10 cGy.…”

Section: Discussionmentioning

confidence: 99%

Challenges with Adjuvant Radiation for Intracranial Chondrosarcoma in Pregnancy

Yadav

Goyal

Madan

et al. 2023

ANAMS

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Background Managing a brain tumor during pregnancy is a highly confusing and challenging situation, complicated by several technical, medical, ethical, and sociocultural concerns. The interests of the mother and child are often pitted against each other, for which legal opinion may occasionally be needed. Case Report We present the report of a young lady with intracranial well-differentiated chondrosarcoma who was determined to be pregnant in the immediate postoperative period. We discuss the management of challenges and dilemmas in devising optimum therapy, and the modifications and care required at each step to help safeguard maternal and fetal health. Risks with therapeutic radiation and measures to assess and pre-empt fetal doses that may assist decision-making are also discussed. Conclusion Radiation therapy during pregnancy is challenging and requires multidisciplinary involvement and psychosocial support for the patient and family.

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Section: Discussionmentioning

confidence: 99%

Challenges with Adjuvant Radiation for Intracranial Chondrosarcoma in Pregnancy

Yadav

Goyal

Madan

et al. 2023

ANAMS

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“…Radiation exposure of embryos and fetuses is of great concern for radiological diagnostics, radioprotection, and human health. Typical fetal doses from diagnostic radiology are usually low but some radio-diagnostic-specific treatments like cancer radiotherapy can expose the fetus to higher and potentially unsafe radiation doses 46 . The deleterious effect of IR to the embryo or fetus is strongly dependent on the stage of development, the absorbed dose, and fractionation 47–49 .…”

Section: Embryonic and Fetal Ddr And Sensitivity To Irmentioning

confidence: 99%

Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity

Fabbrizi

Warshowsky

Zobel

et al. 2018

Cell Death Discovery

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Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-induced depletion of neural stem/progenitor cells in the subgranular zone of the dentate gyrus in the hippocampus where neurogenesis occurs is considered largely responsible for deficiencies such as learning, memory, and spatial information processing in patients subjected to cranial irradiation. Similarly, IR therapy-induced intestinal injuries such as diarrhea and malabsorption are common side effects in patients with gastrointestinal tumors and are believed to be caused by intestinal stem cell drop out. Hematopoietic stem cell transplantation is currently used to reinstate blood production in leukemia patients and pre-clinical treatments show promising results in other organs such as the skin and kidney, but ethical issues and logistic problems make this route difficult to follow. An alternative way to restore the injured tissue is to preserve the stem cell pool located in that specific tissue/organ niche, but stem cell response to ionizing radiation is inadequately understood at the molecular mechanistic level. Although embryonic and fetal hypersensity to IR has been very well known for many decades, research on embryonic stem cell models in culture concerning molecular mechanisms have been largely inconclusive and often in contradiction of the in vivo observations. This review will summarize the latest discoveries on stem cell radiosensitivity, highlighting the possible molecular and epigenetic mechanism(s) involved in DNA damage response and programmed cell death after ionizing radiation therapy specific to normal stem cells. Finally, we will analyze the possible contribution of stem cell-specific chromatin’s epigenetic constitution in promoting normal stem cell radiosensitivity.

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“…Radiation exposure of more than 5-10 rads is the cause for fetal malformations or CNS effects and that too is limited to 18 weeks [17,18]. Hence, the mother should not be deprived of any indicated investigation just to avoid radiation.…”

Section: Investigationsmentioning

confidence: 99%

Trauma in Pregnancy - A Review

Khanna¹

2016

ARGH

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Objective: 1 in 12 pregnant women are affected by major trauma which has an impact on the maternal mortality and morbidity and finally the pregnancy outcome. This requires a multidisciplinary approach for optimum outcome of both mother and the fetus. The aim of this article was to provide the emergency care providers with an evidence based approach which is systematic towards the management of a pregnant trauma patient.Outcomes: Various parameters involved in the management of pregnant females have been considered in this article in the hope to provide adequate information regarding the management of such patients.Evidence: This literature was retrieved through various searches from the Medline, CINAHL, Cochrane library using the following keywords like (trauma, perimortem Cesarean, Kleihauer-Betke, supine hypotension, electrical shock). The results were restricted to various systematic reviews, RCTs and observational studies.

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Prenatal Radiation Exposure: Background Material for Counseling Pregnant Patients Following Exposure to Radiation

Cited by 31 publications

References 10 publications

Challenges with Adjuvant Radiation for Intracranial Chondrosarcoma in Pregnancy

Challenges with Adjuvant Radiation for Intracranial Chondrosarcoma in Pregnancy

Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity

Trauma in Pregnancy - A Review

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