Prenatal Transmission of Dengue: Two New Cases

Boussemart, T; Babe, Philippe; Sibille, G.; Neyret, C.; Berchel, C

doi:10.1038/sj.jp.7200530

Cited by 49 publications

(18 citation statements)

References 4 publications

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“…Several case reports have suggested vertical transmission of DENV from mother to newborn, although none has been definitively confirmed (234)(235)(236)(237). All documented cases of perinatal transmission of DENV thus far are linked to thirdtrimester maternal infection.…”

Section: Humansmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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SUMMARYThe rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested byAedesmosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

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Section: Humansmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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“…Como signo característico, se presenta fiebre que puede iniciarse los primeros 10 días de vida, con una duración entre 1 y 5 días, asociada a exantema petequial, trombocitopenia y actividad hepatocelular variable, que facilitan la confusión con sepsis (9,10). En algunos casos se desarrolla una enfermedad grave, con derrames serosos, compromiso hemodinámico y hemorragia digestiva o intracraneana, principalmente (5).…”

Section: Dengue De La Gestación Y Neonatalunclassified

Dengue perinatal: revisión de la literatura a propósito de un caso

et al. 2012

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Contribución de los autores:Todos los autores participaron en el estudio del caso, la revisión del tema, la búsqueda bibliográfica y la redacción. PRESENTACIÓN DE CASO Biomédica 2013;33(Supl. El dengue es en la actualidad la enfermedad viral más relevante de transmisión vectorial hiperendémica en las Américas. El incremento en el número de casos se ha relacionado con la aparición de dengue durante la gestación y en el periodo neonatal. De acuerdo con la edad de gestación en la que ocurra la infección, podrían presentarse manifestaciones en el feto, como aborto, y en los pacientes a término, dengue neonatal. En este artículo se presenta una reseña de los casos reportados a nivel mundial, y especialmente en las Américas, así como aspectos fisiopatogénicos de la enfermedad.Palabras clave: dengue, fiebre hemorrágica dengue, recién nacido, síndrome HELLP. doi: http://dx.doi.org/10.7705/biomedica.v33i0.1449 Perinatal dengueDengue is currently the most important viral disease transmitted by arthropods and which is hyperendemic in the Americas. An increase in the number of cases is related to dengue during pregnancy and the neonatal period. According to the gestational age in which infection occurs, there could be different manifestations in the fetus including abortion, malformations or neonatal dengue in newborns. This article presents a review regarding some cases reported worldwide, especially in the Americas, and some pathophysiologic issues related to perinatal dengue.

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“…An infrequent number of cases of vertical transmission of acute dengue in neonates were reported in literature [1,2] . Some reviews included confirmed transmissions but in asymptomatic newborns [3] .…”

Section: Tropical Islands In the Caribbeanmentioning

confidence: 99%

Perinatal transmission of acute dengue: First case reported in Turks and Caicos Islands

2017

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We report a newborn baby boy readmitted to the hospital at 7 days of life with acute dengue due to vertical transmission. A 32-year-old primigravida at 38+ weeks of gestation, with no antenatal care and with severe pre-eclampsia, delivered a normal term baby boy by spontaneous vaginal delivery and recovered uneventfully during her postpartum period. The normal term baby boy was admitted to the Neonatal Intensive Care Unit (NICU) for five days due to low birth weight for gestational age, and was asymptomatic except for the transient initial mild thrombocytopenia, from which he recovered uneventfully during the following 48 h. He developed a high-grade fever on day 7 of post-natal life (48 h after being discharged). The baby was treated with appropriate fluid management of antibiotics and paracetamol administered intravenously. Blood cultures were negative and other laboratory findings were unremarkable. He did not have a fever during his admission and was discharged uneventfully after seven days. Clinical diagnosis of acute dengue virus infection was confirmed by laboratory tests of IgG and IgM antibodies in both the baby (on the readmission day) and mother (from the first blood sample on the day of delivery, seven days prior to readmission). The mother acknowledged having fever and bone pain four days prior to delivery; however, the information was not relayed when she was admitted during labor due to language barriers.

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Prenatal Transmission of Dengue: Two New Cases

Cited by 49 publications

References 4 publications

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Dengue perinatal: revisión de la literatura a propósito de un caso

Perinatal transmission of acute dengue: First case reported in Turks and Caicos Islands

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