Prenylated Acetophenone Derivatives from the Leaves of Acronychia pedunculata and Their Anti‐Proliferative Activities

Abstract

Four new prenylated acetophenone derivatives, including one acetophenone dimer [acronyrone D (1)] and three acetophenone monomers [acronyrones E–G (2–4)], along with seven known analogues (5–11) were obtained from the leaves of Acronychia pedunculata. Their structures and absolute configurations were established by analysis of HRMS and NMR data, single crystal X‐ray diffraction studies and quantum chemical calculations. In addition, the isolates were tested for their anti‐proliferative acivity against HCT‐116, RKO and SW480 cancer cell lines. Remarkably, compound 5 exhibited significant anti‐proliferative effects on the three cell lines, with IC50 values ranging from 0.24 to 5.3 μM.