Preoperative imaging for breast conservation surgery—do we need more than conventional imaging for local disease assessment?

Ong, Eugene M. W.

doi:10.21037/gs.2018.08.05

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…However, MRI requires a considerable capital investment, and lengthy examination times can produce patient discomfort and claustrophobia. There is also an ongoing concern that preoperative MRI shows clinically irrelevant tumors and increases mastectomies without patient benefit 17,18 . In recent years, clinical use of contrast-enhanced spectral mammography has shown promise for neoadjuvant therapy monitoring 19 .…”

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confidence: 99%

“…There is also an ongoing concern that preoperative MRI shows clinically irrelevant tumors and increases mastectomies without patient benefit. 17,18 In recent years, clinical use of contrast-enhanced spectral mammography has shown promise for neoadjuvant therapy monitoring. 19 Notwithstanding, studies in large patient populations are still needed to validate initial findings.…”

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confidence: 99%

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Three-Dimensional H-Scan Ultrasound Imaging of Early Breast Cancer Response to Neoadjuvant Therapy in a Murine Model

Tai¹,

Song

et al. 2021

Invest Radiol

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ObjectivesThree-dimensional (3D) H-scan is a new ultrasound (US) technique that images the relative size of acoustic scatterers. The goal of this research was to evaluate use of 3D H-scan US imaging for monitoring early breast cancer response to neoadjuvant therapy using a preclinical murine model of breast cancer.Materials and MethodsPreclinical studies were conducted using luciferase-positive breast cancer–bearing mice (n = 40). Anesthetized animals underwent US imaging at baseline before administration with an apoptosis-inducing drug or a saline control. Image data were acquired using a US scanner equipped with a volumetric transducer following either a shorter- or longer-term protocol. The later included bioluminescent imaging to quantify tumor cell viability. At termination, tumors were excised for ex vivo analysis.ResultsIn vivo results showed that 3D H-scan US imaging is considerably more sensitive to tumor changes after apoptosis-inducing drug therapy as compared with traditional B-scan US. Although there was no difference at baseline (P > 0.99), H-scan US results from treated tumors exhibited progressive decreases in image intensity (up to 62.2% by day 3) that had a significant linear correlation with cancer cell nuclear size (R2 > 0.51, P < 0.001). Results were validated by histological data and a secondary longitudinal study with survival as the primary end point.DiscussionExperimental results demonstrate that noninvasive 3D H-scan US imaging can detect an early breast tumor response to apoptosis-inducing drug therapy. Local in vivo H-scan US image intensity correlated with cancer cell nuclear size, which is one of the first observable changes of a cancer cell undergoing apoptosis and confirmed using histological techniques. Early imaging results seem to provide prognostic insight on longer-term tumor response. Overall, 3D H-scan US imaging is a promising technique that visualizes the entire tumor and detects breast cancer response at an early stage of therapy.

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confidence: 99%

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confidence: 99%

Three-Dimensional H-Scan Ultrasound Imaging of Early Breast Cancer Response to Neoadjuvant Therapy in a Murine Model

Tai¹,

Song

et al. 2021

Invest Radiol

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“…Hence, a reductionist, or minimalist approach to fulfil oncologic requirements may provide optimal results (32,33). Such an approach would require an integration of appropriate preoperative imaging, careful surgical planning and detailed pathologic examination (34,35). This is consistent with the argument by Marescaux et al that iatrogenic impact should be reduced in surgical innovation for patient safety and quality of life (36).…”

Section: The Art Of Bctmentioning

confidence: 64%

Future perspectives for breast conservation treatment: science & art

Tan¹,

Silva

2018

Gland Surg

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“…It has been reported that the ratio of multifocal/multicentric BC ranges from 4 to 50% in different series [33][34][35][36][37]. Addition of MRI to the work up increases multifocal/multicentric tumor rate [38]. Meta-analysis of data from nineteen studies showed that MRI detected additional disease in 16% of women leading to conversion from wide local excision to mastectomy in 11.3% of cases [33,39].…”

Section: Discussionmentioning

confidence: 99%

Comparison of breast cancer patients who underwent partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (M + I) regarding quality of life (QOL), cosmetic outcome and survival rates

et al. 2020

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Purpose: The latissimus dorsi muscle has long been used in breast cancer (BC) patients for reconstruction. This study aimed to compare early stage BC patients who had partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (MI) with respect to quality of life (QoL), cosmetic outcome (CO), and survival rates. Patients and methods: The data of patients who underwent PM + MLDF (Group 1) and M + I (Group 2) between January 2010 and January 2018 were evaluated. Both groups were compared in terms of demographics, clinical and pathological characteristics, surgical morbidity, survival, quality of life, and cosmetic results. The EORTC-QLQ C30 and EORTC-QLO BR23 questionnaires and the Japanese Breast Cancer Society (JBCS) Cosmetic Evaluation Scale were used to assess the quality of life and the cosmetic outcome, respectively.

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Preoperative imaging for breast conservation surgery—do we need more than conventional imaging for local disease assessment?

Cited by 8 publications

References 34 publications

Three-Dimensional H-Scan Ultrasound Imaging of Early Breast Cancer Response to Neoadjuvant Therapy in a Murine Model

Three-Dimensional H-Scan Ultrasound Imaging of Early Breast Cancer Response to Neoadjuvant Therapy in a Murine Model

Future perspectives for breast conservation treatment: science & art

Comparison of breast cancer patients who underwent partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (M + I) regarding quality of life (QOL), cosmetic outcome and survival rates

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