Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study

Karsono, Ramadhan; Purwanto, Denni Joko; Haryono, Samuel J; Karsono, Bambang; Sari, Lenny; Pratiwi, Yulia; Aryandono, Teguh

doi:10.33371/ijoc.v12i4.604

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…Pasien kanker payudara dengan stadium lanjut dan diketahui status hormonalnya kemudian diberikan neoajuvan hormonal terapi sebelum pembedahan menunjukkan overall survival yang lebih baik. 8 Pemeriksaan imunohistokima merupakan bagian dari faktor prognosis dan prediktif dan bermanfaat karena dapat merencanakan intervensi selain dari terapi bedah dan memprediksi hasil terapi serta prognosis. 9 Adanya pemeriksaan imunohistokimia di daerah diharapkan akan mempercepat diketahuinya diagnosis molekuler kanker payudara, sehingga terapi lebih sesuai.…”

Section: Pendahuluanunclassified

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Subiyanto

Kadi²,

Ismaiyah³

et al. 2021

mpk

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Breast cancer is a complex disease with variable molecular characteristics and shows different tumor behavior, therapeutic response, and prognosis. The regional general hospital Madiun has begun to improve services for breast cancer patients since 2015 with the availability of immunohistochemical examinations. This effort was made because breast cancer therapy is currently guided by these examinations. This study aimed to determine the distribution of various molecular subtypes of breast cancer in Madiun Hospital and also the relationship between molecular subtypes and histopathological grading. This study was a retrospective study with a cross-sectional design taken from the Anatomical Pathology Laboratory of Madiun Hospital data from 2015 to 2018. A total of 281 breast cancer cases were examined for immunohistochemical of estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2), and a total of 91 breast cancer patients plus Ki-67 examination were then classified into luminal A, luminal B, HER2 and triple-negative (TN). The statistical test used was the Chi-Square test with a 95% confidence level. The most common molecular subtypes of breast cancer in Madiun Hospital were luminal B (28,5%) followed by TN (27,5%), luminal A (22%), and HER2 (22%). The mean age of breast cancer patients was 52.8 ± 10.57. The most common histological types and grades of breast cancer were invasive ductal carcinoma (85.1%) and tumor grade 1 (58.71%). There was a correlation between the immunohistochemical features of ER, PR, HER2, and Ki67 withhistopathological grading. Positive ER and PR were more well differentiated but e HER2 positive andKi67 were more poorly differented. Abstrak Kanker payudara merupakan penyakit kompleks dengan gambaran molekuler bervariasi dan menunjukkan perilaku tumor, respon terapi, dan prognosis yang berbeda. Rumah Sakit Umum Daerah (RSUD) Madiun mulai meningkatkan layanan untuk pasien kanker payudara sejak tahun 2015 dengan tersedianya pemeriksaan imunohistokimia. Upaya ini dilakukan karena terapi kanker payudara saat ini berpedoman atas pemeriksaan tersebut. Penelitian ini bertujuan untuk mengetahui distribusi berbagai subtipe molekuler kanker payudara di RSUD Madiun dan juga hubungan antar subtipe molekuler dengan grading histopatologi. Penelitian ini adalah studi retrospektif dengan desain cross sectional yang diambil dari data Laboratorium Patologi Anatomi RS Madiun selama tahun 2015 sampai 2018. Total 281 kasus kanker payudara dilakukan pemeriksaan imunohistokimia estrogen receptor (ER), progesteron receptor (PR) dan human epidermal epidermal receptor 2 (HER2) dan total 91 pasien kanker payudara ditambah pemeriksaan Ki-67 kemudian diklasifikasikan menjadi luminal A, luminal B, HER2, dan triple negative (TN). Uji statistik yang digunakan adalah uji Chi Square dengan taraf kepercayaan 95%. Subtipe molekuler kanker payudara di RS Madiun yang paling banyak adalah luminal B (28,5%) diikuti TN (27,5%), luminal A (22%), dan HER2 (22%). Rata-rata umur pasien kanker payudara adalah 52,8 ±10,57. Tipe histologi dan grade kanker payudara terbanyak adalah karsinoma duktal invasif (85,1%) dan grade tumor 1 (58,71%). Terdapat hubungan gambaran imunohistokimia baik ER, PR, HER2 dan Ki67 dengan grading histopatologi. ER dan PR positif lebih banyak mengalami diferensiasi baik namun HER2 positif dan KI67 positif lebih banyak mengalami diferensiasi buruk.

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Section: Pendahuluanunclassified

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Subiyanto

Kadi²,

Ismaiyah³

et al. 2021

mpk

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“…patients depends on technological advancement such as immunohistochemistry and biomolecular assay. 4,6 Management of breast cancer also has some adverse effects. In addition, factors of age, co-morbid disease , evidence-based study, cost effective utility, and when to stop the systemic treatment should be considered.…”

Section: Bioscientia Medicina: Journal Of Biomedicine and Translational Researchmentioning

confidence: 99%

The Ethanolic Extract of Annonaceous sp. to Inhibit Vascular Endothelial Growth Factor (VEGF) as Anticancer Modalities

Muhartono

Sukohar

Nisa

et al. 2021

bsm

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Introduction: Cancer has become a major public health problem worldwide, with breast cancer is the most common cancer among women and one of the most important causes of death among them. Management of breast cancer have some adverse effects, with many factorx=s shiouln be considered to ordered the therapy. Use of chemotherapy will suppress cell proliferation and trigger apoptosis, but it cannot just focus on cancer cells only, but also would affected on other cells and cause. Objective: This study aim to analyze the inhibition effect of the Annonanceous sp. ethanolic extract to Vascular Endothelial Growth Factor (VEGF) on MCF-7 cells line Material and Methods: This study is an analytic experimental study used Randomized Complete Block Design (RCBD) with three repetitions. The extract was dissolved in 1 ml of DMSO with a concentration of 0.1%. Furthermore, dilution was made with a dose of 0 µg / ml (K); 25 µg / ml (P1); 50 µg / ml (P2); 100 µg / ml (P3); 200 µg / ml (P4). MCF-7 cells line were cultured used RPMI 1640 Medium with 80 – 90% confluent. The ethanolic extract of Annonaceous sp. were exposed to MCF-7 cells for 48 hours. Analyze of VEGF level use ELISA Methods with λ=405 nm. Results: The results of ELISA analyze shows that the ethanolic extract of Annonaceous sp. have potential effect to decreased of VEGF expression on sample with treatment on some concentration (p< 0,05). Conclusion: The ethanolic extract of Annonaceous sp. has shows the potential effect to decreased of VEGF level on MCF-7 cells line

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“…It was reported by WHO that nearly 1.38 million cases of breast cancer were diagnosed in 2008 [1] , with a prevalence rate of 23% of all cancer cases in the world. In addition, it is known that 209,000 new cases were found, especially in Southeast Asia [2] . According to the International Agency on Research in Cancer, breast cancer has become the most common malignant tumor among Indonesian women [3] .…”

Section: Introductionmentioning

confidence: 99%

“…The results of the QSAR Machie learning quantitatively describe the pIC50 value of the compound and a qualitative description of the target protein. The pIC50 value is the same as Log IC50 Peronemine A2 (1) and B2 (2).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies

Fikriansyah,

Nelson,

Latief

et al. 2023

chempublish

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Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.

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Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study

Cited by 5 publications

References 22 publications

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

The Ethanolic Extract of Annonaceous sp. to Inhibit Vascular Endothelial Growth Factor (VEGF) as Anticancer Modalities

Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies

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