Preoperative Peripheral Blood Count in Breast Carcinoma: Predictor of Prognosis or a Routine Test

Rana, Anubhuti; Kaur, Manjit; Zonunsanga, B.; Puri, Archana; Kuka, Amarjit Singh

doi:10.1155/2015/964392

Cited by 22 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[17][18][19] Many other scientists also observed changes in different stages of breast cancer. 15,[20][21][22] In the current study, we found that patients which were on radio-chemotherapy (both) had decreased mean values in all parameters as compared to individual therapies. Normally, blood cells are placed among the most rapidly dividing cells in the body and the most sensitive to chemotherapy and radiotherapy.…”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Comparative study of hematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer

et al. 2016

View full text Add to dashboard Cite

Background: Breast cancer is one of the most common malignancies found among women in India. Haematological parameters have been shown to predict severity, mortality and treatment follow-up in breast cancer patients. The aim of the study was to compare haematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer patients.Methods: Total 235 human subjects were taken in the study. Out of which 100 normal ages matched healthy subjects were considered as controls and 135 breast cancer patients subjects as cases which were further divided into their respective stages according to TNM classification.Results: Estimation of haematological parameters was done by Sysmex Automated Hematology Analyzer Kx-21. The statistical differences between cases and control were determined by using student independent sample t-test.Conclusions: We found hemoglobin level, polymorphs, lymphocytes, monocytes and RBC count were statistically reduce (p<0.05) while other parameters were non-significant as compared to control healthy subjects. We also found deranged haematological parameters in all four stages of breast cancer. The data also indicated that patients which were on combined therapies i.e. radio and chemo have more deranged and decreased levels of haematological parameters as compared to individual therapies.

show abstract

Section: Discussionmentioning

confidence: 82%

“…14 Rana Singh AP et al also reported decrease in absolute lymphocyte count with increase in stage of carcinoma. 15 Ufelle SA et al reported significant decrease in all hematological parameters in breast cancer when compared with control. 16 This is in accordance with our study.…”

Section: Discussionmentioning

confidence: 96%

Comparative study of hematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A case control studies carried out by Akinsegun [40] on breast cancer found 58 out 100 of the cases to be anaemic. However, [48] in a study to assess the perioperative blood count in breast carcinoma found no significant correlation between cancer patients and anaemia. Anaemia is associated with shorter survival in cancer patients and this association has been established for breast cancer and almost all types of cancer studied [18,[49][50].…”

Section: Discussionmentioning

confidence: 96%

Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

Osaro¹,

Me²,

Michael³

et al. 2018

J Pregnancy Reprod

View full text Add to dashboard Cite

Breast cancer is the most common female malignancy both in Nigeria and globally. The aim of this case-control study was to determine the changes in some haematological parameters among breast cancer patients in Sokoto, Nigeria. The study included a total of 46 breast cancer subjects (mean age 42.91 ± 5.83 years) visiting the Specialist Hospital, in Sokoto, North Western Nigeria. A total of 46 apparently healthy age-matched women were monitored as control. Some haematological (packed cell volume, total white blood cell count and platelet count) were analyzed using the auto-haematology analyzer (Genesis, HA6000). Breast cancer staging was determined using the TNM classification. Data were analyzed using SPSS 22.0 statistical package. A p-value ≤0.05 was considered significant in all comparisons. The result indicated that patients with breast cancer had a lower mean packed cell volume (29.20 ± 0.50 %) compared to controls (36.20 ± 0.42 %) (p=0.000). The mean total white blood cell count of patients was also statistically lower among breast cancer patients (3.91 ± 0.19×10 9 /l) compared to controls (4.38 ± 0.13×10 9 /l) (p=0.045). There were no statistically significant differences in the mean value of platelet counts of breast cancer patients (197 ± 5.06×10 9 /l) and controls (207 ± 5.84×10 9 /l) (p=0.217). Newly diagnosed patients who were not on therapy had significantly lower mean values of PCV compared to controls (p<0.05). There were no statistically significant differences in the mean values of total white blood cell counts and platelets count of newly diagnosed patients that are not on therapy and controls (p>0.05). The mean PCV levels were significant lower as compared to controls (p<0.05) Patients that were on chemotherapy had significantly lower values of PCV, total white cell counts and platelets compared to patients who were not yet on any therapy (p <0.05). There were no statistically significant differences in the PCV, total white blood cell counts and platelets based on the different stages of breast cancer (p >0.05). Findings of this study have shown that breast cancer patients had a lower PCV and TWBC count compared to controls. Chemotherapy further exerts adverse effects on patients as seen with the significantly decreased values of haematological parameters on patients on therapy. Findings of this study also shows that breast cancer patients have low PCV and WBC count compared to controls. Haematological investigation should be taken as an essential tool in the investigation and management of breast cancer. Active breast cancer awareness campaign should be carried out on the need for early diagnosis. More research should be carried out to investigate the pattern of other haematological parameters in breast cancer disease.

show abstract

“…Complete blood count reflects the response of cellular immunity in a patient with cancer [12]. The Erythopoietic indices of DMBA administered albino rats, given aqueous concentrate of the different plants is appeared on Table 1 & 2.…”

Section: Discussionmentioning

confidence: 99%

“…Anaemia is a common disease faced in cancer patients (such as cervical, ovarian, and endometrial cancer) and, as a result, anaemic patients suffer from shortness of breath, fatigue, and shrunk energy. Haemoglobin (Hb) and packed cell volume (PCV) are indirectly connected with raised risk of cardiac failure in cancer patients [12]. Furthermore, systemic inflammatory response has been identified to affect survival in a number of malignancies, of which white blood cells are key mediators in this response.…”

Section: Introductionmentioning

confidence: 99%

Effect of selected plants on Haematological parameters of DMBA-induced breast cancer of albino rats

Brantley¹

2019

IJBP

View full text Add to dashboard Cite

The present study was aimed to investigate the effect of selected plants on haematological parameters of DMBA induced breast cancer of albino rats. Sixty-three female albino rats were used for the study and they were grouped into nine groups of seven animals each. Group I (control) was fed with normal feed. Groups II to IX, were orally administered 20mg DMBA/kg to induce tumour. Group II was untreated; Group III was treated with tamoxifen(6.6mg/kg). Groups IV-IX were treated with 500mg/kg Sorghum vulgare, 1000mg/kg Sorghum vulgare, 500mg/kg Eremomastax polysperma; 1000mg/kg Eremomastax polysperma, 500mg/kg Brillantaisia owariensis and 1000mg/kg Brillantaisia owariensis respectively. Treatment with the different aqueous concentrate demonstrated significant increase (p≤ 0.05) of haemoglobin, and packed cell volume levels of the treated groups when compared to the DMBA group. There was a decrease in Neutrophil, N/L, P/L and platelets level in the treated groups when compared to the DMBA group (though not significant, p≤ 0.05). The present study reveals that the plants might be able to reduce anaemia posed as a result of breast cancer.

show abstract

Preoperative Peripheral Blood Count in Breast Carcinoma: Predictor of Prognosis or a Routine Test

Cited by 22 publications

References 21 publications

Comparative study of hematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer

Comparative study of hematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer

Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

Effect of selected plants on Haematological parameters of DMBA-induced breast cancer of albino rats

Contact Info

Product

Resources

About