Preoperative Prognostic Nutritional Index Predicts Long‐Term Surgical Outcomes in Patients with Esophageal Squamous Cell Carcinoma

Hirahara, Noriyuki; Tajima, Yoshitsugu; Fujii, Yusuke; Kaji, Shunsuke; Yamamoto, Tetsu; Hyakudomi, Ryoji; Taniura, Takahito; Miyazaki, Yoshiko; Kishi, Takashi; Yasunari, Kenichi

doi:10.1007/s00268-017-4437-1

Cited by 55 publications

(45 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two studies [11,13] provided the CSS data about PNI in ESCC. The pooled HR was 1.352 (95%CI 0.991–1.845) which showed that low-PNI did not show any prognostic significance on CSS ( P = .057) with significant heterogeneity ( I 2 = 90.4%, P = .001) (Fig.…”

Section: Resultsmentioning

confidence: 99%

The prognostic value of pre-treatment prognostic nutritional index in esophageal squamous cell carcinoma

Wang

Lai

et al. 2019

Medicine

View full text Add to dashboard Cite

Background: Prognostic nutritional index (PNI) is an easily obtained index inflecting both one's nutritional and inflammatory status. Its clinical role in esophageal squamous cell carcinoma (ESCC) remains still in debate. The aim of this meta-analysis was to assess the prognostic value and the clinical-pathological features of pre-treatment PNI in ESCC patients. Methods: A comprehensive search of online databases (PubMed, Embase, Web of Science) was performed. Studies explored the relationship between pre-treatment PNI and long-term survival of ESCC patients were regarded eligible for this meta-analysis. Outcomes were extracted and synthesized. Hazard ratio (HR) and relative ratio (RR) with 95% confidence interval (CI) were used to evaluate the prognostic value of PNI on long-term survival and association with clinical-pathological features, respectively. The heterogeneity levels and publication bias between studies were also estimated. Results: Nine observational studies involving 2276 patients were considered eligible for this meta-analysis. The pooled results showed that low PNI score was significantly correlated with poorer overall survival (OS) of esophageal cancer (pooled HR = 1.418 95%CI: 1.200–1.676, P = .000), poorer recurrence free survival (HR = 1.880 95%CI: 1.207–2.929, P = .005) but not cancer specific survival (CSS) (HR = 1.948 95%CI: 0.544–6.977, P = .306). The PNI value was not related with patient age, sex, depth of tumor invasion, nodular metastasis, and differential grade but the TNM stage (III/IV vs 0/I/II, RR = 1.276, 95% CI 1.146–1.420). Conclusions: Low pre-treatment PNI was significantly related with OS and recurrence free survival but not CSS for ESCC. PNI was a reliable prognostic factor of ESCC, and higher stage ESCC have higher incidence of low PNI.

show abstract

Section: Resultsmentioning

confidence: 99%

The prognostic value of pre-treatment prognostic nutritional index in esophageal squamous cell carcinoma

Wang

Lai

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

“…The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated as ANC/ALC and platelet count/ALC, respectively. In addition, we calculated the prognostic nutritional index (PNI), which is associated with the survival outcome and nutritional status of cancer patients, including esophageal cancer patients [24,25]. PNI was calculated as (10 × albumin [g/dL] + 0.005 × ALC) [26].…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

Prognostic Impact of Sarcopenia and Skeletal Muscle Loss During Neoadjuvant Chemoradiotherapy in Esophageal Cancer

Yoon

Ahn

et al. 2020

Cancers

View full text Add to dashboard Cite

Backgrounds: The relationship between sarcopenia, characterized by loss of muscle mass and strength, and survival outcomes of esophageal cancer is controversial. This study aimed to assess the effect of sarcopenia and skeletal muscle loss on overall survival (OS) and recurrence-free survival (RFS) of esophageal cancer patients. Methods: We retrospectively collected the medical records of 248 male patients diagnosed with squamous cell esophageal cancer and who underwent neoadjuvant chemoradiotherapy (NACRT) followed by surgery. We measured the cross-sectional area of the skeletal muscle at the L3 vertebra level using computed tomography images and calculated the skeletal muscle index (SMI). Sarcopenia was defined as SMI <52.4 cm2/m2, and excessive muscle loss was defined as SMI change <−10.0%/50 days during NACRT. Moreover, laboratory test results, such as albumin, prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) before and after NACRT, were collected. Results: In the univariable Cox analysis, pre- (p = 0.689) and post-radiotherapy (RT) sarcopenia (p = 0.669) were not associated with OS. However, excessive muscle loss had a significant association with OS in both the univariable and multivariable analyses (all p = 0.001). Excessive muscle loss was also related to RFS in both the univariable (p = 0.011) and multivariable (p = 0.022) Cox analysis. Patients with excessive muscle loss had significantly lower levels of post-RT albumin (p < 0.001) and PNI (p < 0.001), higher levels of post-RT NLR (p = 0.031) and PLR (p = 0.071), larger decrease in albumin (p < 0.001) and PNI (p < 0.001) after NACRT, and larger increase in NLR (p = 0.051) and PLR (p = 0.088) after NACRT than in those with non-excessive muscle loss. Conclusion: Excessive muscle loss rather than pre- and post-RT sarcopenia was a significant prognostic factor for OS and RFS, and it was also related to nutritional and inflammatory markers.

show abstract

“…Recently, a body of studies showed that pretreatment PNI was correlated with the prognosis of patients with a variety of human malignancies, such as esophageal squamous cancer, colorectal cancer, gastric cancer, and lung cancer. [7][8][9][10][11][12] However, most of the relevant studies about NSCLC were conducted with a small sample size, which limits the statistical power of their conclusions. Therefore, we performed this meta-analysis to provide more persuasive evidence that supports the prognostic significance of PNI in NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis

Hu¹,

Shen

Liu

et al. 2018

Int J Biol Markers

View full text Add to dashboard Cite

Background: The pretreatment prognostic nutritional index has been considered a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC), but this remains controversial. Therefore, we performed a metaanalysis to systematically assess the prognostic value of the prognostic nutritional index in patients with NSCLC. Methods: We systematically searched PubMed, EMBASE, Web of Science, and CNKI. The hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were used to evaluate the link between the prognostic nutritional index and the oncological outcomes of patients with NSCLC, including overall survival, disease-free survival/recurrencefree survival, and progression-free survival. Results: Fifteen studies were included in this meta-analysis. Twelve of these studies explored the association between the prognostic nutritional index and the overall survival of patients with NSCLC. Our pooled analysis indicated that a low prognostic nutritional index was significantly related to adverse overall survival (HR 1.61; 95% CI 1.44, 1.81; P < 0.001). Our results also showed that the prognostic nutritional index was a negative predictor for disease-free survival/ recurrence-free survival, and progression-free survival in patients with NSCLC. Conclusion: Our meta-analysis demonstrated that there was a close association between the prognostic nutritional index value and prognosis in NSCLC patients and that the prognostic nutritional index may act as a useful prognostic biomarker in NSCLC patients.

show abstract

Preoperative Prognostic Nutritional Index Predicts Long‐Term Surgical Outcomes in Patients with Esophageal Squamous Cell Carcinoma

Cited by 55 publications

References 48 publications

The prognostic value of pre-treatment prognostic nutritional index in esophageal squamous cell carcinoma

The prognostic value of pre-treatment prognostic nutritional index in esophageal squamous cell carcinoma

Prognostic Impact of Sarcopenia and Skeletal Muscle Loss During Neoadjuvant Chemoradiotherapy in Esophageal Cancer

Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis

Contact Info

Product

Resources

About