Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

Esmaeili, Farnaz; Hosseini-Nasr, Mahdi; Rad‐Malekshahi, Mazda; Samadi, Nasrin; Atyabi, Fatemeh; Dinarvand, Rassoul

doi:10.1016/j.nano.2007.03.003

Cited by 130 publications

(86 citation statements)

References 19 publications

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“…22 Briefly, for the preparation of EGCG-encapsulated PLGA-NPs, the drug to polymer ratio was kept at 1:5. EGCG (20 mg) was dissolved in deionized water (0.5 mL),and emulsified with a solution of PLGA (100 mg) dissolved in dichloromethane (2 mL) in an ice bath on a magnetic stirrer operating at 1,600 rpm.…”

Section: Preparation Of Tf/egcg-loaded Plga-npsmentioning

confidence: 99%

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Singh¹,

Bhatnagar²,

Mishra³

et al. 2015

IJN

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The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability. Herein, following the concept of nanochemoprevention, which uses nanotechnology for enhancing the efficacy of chemotherapeutic drugs, we employed tea polyphenols, namely theaflavin (TF) and epigallocatechin-3-gallate (EGCG) encapsulated in a biodegradable nanoparticulate formulation based on poly(lactide-co-glycolide) (PLGA) with approximately 26% and 18% encapsulation efficiency, respectively. It was observed that TF/EGCG encapsulated PLGA nanoparticles (NPs) offered an up to ~7-fold dose advantage when compared with bulk TF/EGCG in terms of exerting its antiproliferative effects and also enhanced the anticancer potential of cisplatin (CDDP) in A549 (lung carcinoma), HeLa (cervical carcinoma), and THP-1 (acute monocytic leukemia) cells. Cell cycle analysis revealed that TF/EGCG-NPs were more efficient than bulk TF/EGCG in sensitizing A549 cells to CDDP-induced apoptosis, with a dose advantage of up to 20-fold. Further, TF/EGCG-NPs, alone or in combination with CDDP, were more effective in inhibiting NF-κB activation and in suppressing the expression of cyclin D1, matrix metalloproteinase-9, and vascular endothelial growth factor, involved in cell proliferation, metastasis, and angiogenesis, respectively. EGCG and TF-NPs were also found to be more effective than bulk TF/EGCG in inducing the cleavage of caspase-3 and caspase-9 and Bax/Bcl2 ratio in favor of apoptosis. Further, in vivo evaluation of these NPs in combination with CDDP showed an increase in life span ( P <0.05) in mice bearing Ehrlich’s ascites carcinoma cells, with apparent regression of tumor volume in comparison with mice treated with bulk doses with CDDP. These results indicate that EGCG and TF-NPs have superior cancer chemosensitization activity when compared with bulk TF/EGCG.

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Section: Preparation Of Tf/egcg-loaded Plga-npsmentioning

confidence: 99%

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Singh¹,

Bhatnagar²,

Mishra³

et al. 2015

IJN

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“…Hydrophilic particles lean to remain in the blood for a longer time (Soppimath et al, 2001;Bala et al, 2004;Astete and Sabliov, 2006;Dinarvand et al, 2011). Zeta potential determined by Zetasizer (Ravi Esmaeili et al, 2007b;Esmaeili et al, 2008a). The zeta potential values may be positive or negative depending on the nature of the polymer or the material used for surface modification.…”

Section: Nanoparticle Characterization Techniquesmentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

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“…Size exclusion chromatography [58][59][60] Surface chemistry analysis X-ray photoelectron spectroscopy 28,61,62 Fourier transform infrared spectroscopy 54,63,64 Nuclear magnetic resonance spectroscopy [64][65][66] Surface charge Zetasizer 56,67,68 Crystallinity X-ray diffraction 37,69,70 Differential scanning calorimetry [71][72][73] Hydrophobicity, hydrophilicity water contact angle measurements 65,74,75 Hydrophobic interaction chromatography [76][77][78] Drug entrapment efficiency, drug release studies…”

Section: Molecular Weightmentioning

confidence: 99%

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand¹,

Sepehri²,

Manoochehri³

et al. 2011

IJN

Self Cite

396

265

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The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.

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Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

Cited by 130 publications

References 19 publications

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

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Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

Cited by 130 publications

References 19 publications

PLGA-encapsulated tea polyphenols enhance the&nbsp;chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-encapsulated tea polyphenols enhance the&nbsp;chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Contact Info

Product

Resources

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PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma