Preparation and characterization of electrospun shape memory polyurethane/graphene quantum dot nanocomposite scaffolds for tissue engineering

Nejad, Sanaz Sarabiyan; Razzaghi, Donya; Rezaei, Mehran; Bagheri, Massuomeh; Babaie, Amin; Abbasi, Farhang

doi:10.1080/00914037.2021.1941954

Cited by 11 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The agglomeration of GQD at higher concentrations resulted in a decrease in the compressive modulus of the PCL/ GQD scaffold. 35,57 Nevertheless, the compressive modulus of the 3 and 5 wt % PCL/G scaffolds (101.44 ± 0.45 and 103.54 ± 0.18 MPa respectively) and all PCL/GQD scaffolds (97.01 ± 0.05 to 90.15 ± 0.04 MPa) were still higher than that of the PCL scaffolds (87.08 ± 0.147 MPa).…”

Section: Carbon Nanomaterials Characterizationmentioning

confidence: 90%

“…Multiple research has been conducted on G or other G-based materials reinforced scaffolds, while current investigation on GQD is limited to films and membranes (which cannot emulate complex in vitro and in vivo environments) rather than 3D structures or bone tissue engineering applications. − The information on comparing G and GQD under the same loading concentration to bone tissue engineering scaffolds is also extremely limited. This paper, for the first time, investigates and compares different loading levels of G and GQD for bone tissue engineering applications, particularly the engineering of 3D PCL bone tissue engineering scaffolds with a controlled architecture through additive manufacturing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

3D-Printed Graphene and Graphene Quantum Dot-Reinforced Polycaprolactone Scaffolds for Bone-Tissue Engineering

Meng,

Hou,

Kurniawan

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

The regeneration of large-scale bone loss due to accidents, trauma, diseases, or tumor resection is still a critical clinical challenge. With the development of additive manufacturing technology and advanced biomaterials, 3D-printed biocompatible synthetic polymer scaffolds have been widely studied for their key roles in supporting bone tissue regeneration. Scaffold aims to provide mechanical properties that match the host bone as well as biological activities that can effectively promote cell proliferation and differentiation, ultimately facilitating bone tissue regeneration. Due to its unique biocompatibility and biodegradability, polycaprolactone (PCL) becomes one of the dominant synthetic polymeric materials considered for scaffold fabrication. However, using PCL alone presents insufficient mechanical properties; thus, different functional fillers have been added to modulate both the mechanical and biological performance of fabricated scaffolds. Among all functional fillers, carbon nanomaterials, particularly graphene (G), have shown an emerging trend. Graphene quantum dots (GQD), a member of the graphene family, are regarded as an ideal next-generation functional filler for scaffold fabrication. It presents high solubility in water, controllable dose-dependent cytotoxicity similar to that of G, and unique biological properties benefiting from smaller sizes. Current research using GQD for tissue engineering applications is limited, and the systemic comparison between G and GQD at different concentrations is also missing. This study, for the first time, evaluates and compares the impact of incorporating G and GQD into PCL bone tissue engineering scaffolds from surface, thermal, mechanical, and biological perspectives. Results suggested that the addition of both materials under 5 wt % significantly improved both the mechanical and biological performance of PCL scaffolds. Under 3 wt %, PCL/GQD scaffolds presented better compressive strength while maintaining the same level of biological performance compared with PCL/G scaffolds, revealing the strong potential for future in vivo studies and bone tissue regeneration applications.

show abstract

Section: Carbon Nanomaterials Characterizationmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

3D-Printed Graphene and Graphene Quantum Dot-Reinforced Polycaprolactone Scaffolds for Bone-Tissue Engineering

Meng,

Hou,

Kurniawan

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Further studies have been reported in 2021 in order to produce scaffolds and medical devices. For instance, Sarabiyan et al [160] fabricated SMPU/graphene quantum dot nanoparticle (GQDs) nanofibers. The presence of PCL as the soft segment in the structure contributed to the shape-memory behavior of the material.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Shape-Memory Materials via Electrospinning: A Review

et al. 2022

View full text Add to dashboard Cite

This review aims to point out the importance of the synergic effects of two relevant and appealing polymeric issues: electrospun fibers and shape-memory properties. The attention is focused specifically on the design and processing of electrospun polymeric fibers with shape-memory capabilities and their potential application fields. It is shown that this field needs to be explored more from both scientific and industrial points of view; however, very promising results have been obtained up to now in the biomedical field and also as sensors and actuators and in electronics.

show abstract

“…In another study, a biocompatible composite with GQD nanoparticles were proposed by Sarabiyan Nejad et al 107 with wound-healing applications. They generated electrospun nanofibers from a solution including polycaprolactone and GQD nanoparticles.…”

Section: Different Biomedical Applications Of Gqdmentioning

confidence: 99%

A review of graphene quantum dots and their potential biomedical applications

et al. 2022

View full text Add to dashboard Cite

Today, nanobiotechnology is a pioneering technology in biomedicine. Every day, new nanomaterials are synthesized with elevated physiochemical properties for better diagnosis and treatment of diseases. One advancing class of materials is the Graphene family. Among different kinds of graphene derivatives, graphene quantum dots (GQDs) show fantastic optical, electrical, and electrochemical features originating from their unique quantum confinement effect. Due to the distinct properties of GQD, including large surface-to-volume ratio, low cytotoxicity, and easy functionalization, this nanomaterial has gone popular in biomedical field. Herein, a short overview of different strategies developed for GQD synthesis and functionalization is discussed. In the following, the most recent progress of GQD based nanomaterials in different biomedical fields, including bio-imaging, drug/gene delivery, antimicrobial, tissue engineering, and biosensors, are reviewed.

show abstract

Preparation and characterization of electrospun shape memory polyurethane/graphene quantum dot nanocomposite scaffolds for tissue engineering

Cited by 11 publications

References 49 publications

3D-Printed Graphene and Graphene Quantum Dot-Reinforced Polycaprolactone Scaffolds for Bone-Tissue Engineering

3D-Printed Graphene and Graphene Quantum Dot-Reinforced Polycaprolactone Scaffolds for Bone-Tissue Engineering

Shape-Memory Materials via Electrospinning: A Review

A review of graphene quantum dots and their potential biomedical applications

Contact Info

Product

Resources

About