Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

Abstract

Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolving JFW in WGO at 70 °C and cooling it to room temperature (25 °C). The critical gelation concentration of JFW that induces the gelation of WGO was found to be 10% (w/w). The OGs were characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopic analysis, and mechanical test. XRD data indicated that JFW influences the crystallinity of the OGs. Among the prepared OGs, OG 17.5 showed higher crystallization in the series. Optical microscopic studies demonstrated the formation of fiber structures due to the entanglement of crystals whereas, polarized light micrographs suggested the formation of spherulites or clustered crystallite structures. The mechanical properties of the OGs increased linearly with the increase in the JFW concentration. Curcumin-loaded OGs were examined for their controlled release applications. In summary, the developed OGs were found to have the necessary features for modulating the oral delivery of curcumin.

Silver Nanoparticles From Cassia alata L. Incorporated to Coconut Oil‐Oleogel Based Ointment As An Alternative for Diabetes Mellitus Wound Healing: Optimization, In Vitro and In Vivo Tests

“…This oleogel, in turn, establishes a noteworthy affinity with oils such as virgin coconut oil, highlighting the considerable potential of Na‐CMC derived from water hyacinth as an efficient and sustainable organic raw material [25] . Coconut oil, rich in saturated fatty acids, can be utilized due to its ability to form a denser three‐dimensional network crystal structure [26] …”

“…[25] Coconut oil, rich in saturated fatty acids, can be utilized due to its ability to form a denser three-dimensional network crystal structure. [26] Oleogel, formed by immobilizing organic oils into polymeric structures, presents a semi-solid system with coconut oil (VCO) as a suitable candidate due to its fatty acid composition. The addition of beeswax as an oleogelator contributes to the formation of a well-structured three-dimensional crystal network.…”

Food-Grade Oleogels: Trends in Analysis, Characterization, and Applicability

“…For example, they can be used in food products as a replacement or for the reduction of solid fats, such as trans fats or hydrogenated fats, to create healthier options without compromising their texture, mouthfeel, and stability [1,[29][30][31][32][33][34][35][36]. Oleogels can also be used to encapsulate and deliver bioactive compounds, such as antioxidants or flavors, in food products, providing enhanced stability and controlled-release properties [2,[37][38][39][40][41][42][43][44]. Additionally, oleogels can offer new possibilities for product innovation by creating unique textures, structures, and sensory experiences in food products [45].…”

Effect of Cholesterol on Oral Delivery of Curcumin Using Oleogels Containing Wheat Germ Oil and Rose Floral Wax

“…In this aspect, naturally occurring materials such as rose and wheat germ oil (WGO) can be used as raw materials for the synthesis of OG. 16,17 A Rosaceae family member, the rose, is a woody blossoming plant. There are more than 300 species and 10,000 cultivars.…”

“…In search of efficient oleogelators to be utilized as drug delivery agents, researchers tried to find natural resources from which the oleogelators can be extracted. In this aspect, naturally occurring materials such as rose and wheat germ oil (WGO) can be used as raw materials for the synthesis of OG. , …”