Preparation and characterization of poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/gelatin composite nanofibrous

Yang, Qiang; Guo, Jing; Liu, Yuanfa; Guan, Fang; Sun, Fanchen; Gong, Xueyong

doi:10.1016/j.surfin.2022.102231

Cited by 3 publications

(2 citation statements)

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“…This improvement is likely attributed to the formation of hydrogen bonds between PGS and Gel [35]. Similar hydrogen bonding interactions have been observed in other studies, such as the confirmation of hydrogen bond formation between Gel and poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3,4HB) polyester [36].…”

Section: Discussionsupporting

confidence: 87%

PGS/Gelatin Nanocomposite Electrospun Wound Dressing

Naseri,

Hedayatnazari,

Tayebi

2023

J. Compos. Sci.

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Infectious diabetic wounds can result in severe injuries or even death. Biocompatible wound dressings offer one of the best ways to treat these wounds, but creating a dressing with a suitable hydrophilicity and biodegradation rate can be challenging. To address this issue, we used the electrospinning method to create a wound dressing composed of poly(glycerol sebacate) (PGS) and gelatin (Gel). We dissolved the PGS and Gel in acetic acid (75 v/v%) and added EDC/NHS solution as a crosslinking agent. Our measurements revealed that the scaffolds’ fiber diameter ranged from 180.2 to 370.6 nm, and all the scaffolds had porosity percentages above 70%, making them suitable for wound healing applications. Additionally, we observed a significant decrease (p < 0.05) in the contact angle from 110.8° ± 4.3° for PGS to 54.9° ± 2.1° for PGS/Gel scaffolds, indicating an improvement in hydrophilicity of the blend scaffold. Furthermore, our cell viability evaluations demonstrated a significant increase (p < 0.05) in cultured cell growth and proliferation on the scaffolds during the culture time. Our findings suggest that the PGS/Gel scaffold has potential for wound healing applications.

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Section: Discussionsupporting

confidence: 87%

PGS/Gelatin Nanocomposite Electrospun Wound Dressing

Naseri,

Hedayatnazari,

Tayebi

2023

J. Compos. Sci.

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“…In addition to PCL and PLLA, PHB can also be utilized with HA to form a composite material. As a member of the polyhydroxyalkanoate family, PHB is characterized by non-biotoxic degradation products that can be easily metabolized by organisms, making it a highly biocompatible and osteoinductive material that has been used extensively in biomedical and tissue engineering applications [ 51 , 199 ]. Degli Esposti et al .…”

Section: Reviewmentioning

confidence: 99%

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

Wu,

Zou,

Tang

et al. 2024

Burns &Amp; Trauma

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The unique ability of piezoelectric materials to generate electricity spontaneously has attracted widespread interest in the medical field. In addition to the ability to convert mechanical stress into electrical energy, piezoelectric materials offer the advantages of high sensitivity, stability, accuracy and low power consumption. Because of these characteristics, they are widely applied in devices such as sensors, controllers and actuators. However, piezoelectric materials also show great potential for the medical manufacturing of artificial organs and for tissue regeneration and repair applications. For example, the use of piezoelectric materials in cochlear implants, cardiac pacemakers and other equipment may help to restore body function. Moreover, recent studies have shown that electrical signals play key roles in promoting tissue regeneration. In this context, the application of electrical signals generated by piezoelectric materials in processes such as bone healing, nerve regeneration and skin repair has become a prospective strategy. By mimicking the natural bioelectrical environment, piezoelectric materials can stimulate cell proliferation, differentiation and connection, thereby accelerating the process of self-repair in the body. However, many challenges remain to be overcome before these concepts can be applied in clinical practice, including material selection, biocompatibility and equipment design. On the basis of the principle of electrical signal regulation, this article reviews the definition, mechanism of action, classification, preparation and current biomedical applications of piezoelectric materials and discusses opportunities and challenges for their future clinical translation.

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