Preparation and characterization of polyvinyl alcohol stabilized griseofulvin nanoparticles

Kumar, Raj; Siril, Prem Felix

doi:10.1016/j.matpr.2016.04.135

Cited by 23 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the objective of each mode of mixing was different. In the conventional EASAI method, a single spray of the solution onto the surface of the antisolvent was used to yield very fine nanoparticles. , However, increasing the solid loading remains a challenge to be addressed, as increasing the concentration or the ratio of solvent to antisolvent results in relatively larger particles. In the DBD method, the solution was added DBD to the antisolvent, using microfluidics MITOS pressure-pump at the optimized experimental conditions of the EASAI method.…”

Section: Resultsmentioning

confidence: 99%

Engineering the Morphology and Particle Size of High Energetic Compounds Using Drop-by-Drop and Drop-to-Drop Solvent–Antisolvent Interaction Methods

2019

Self Cite

View full text Add to dashboard Cite

Morphology-controlled precipitation of three powerful organic high energetic compounds (HECs) viz. cyclotrimethylenetrinitramine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and 2-methyl-1,3,5-trinitrobenzene (TNT) was achieved by two different processes, namely, drop-by-drop (DBD) and drop-to-drop (DTD) solvent–antisolvent interaction methods. Effect of different experimental parameters on the mean size and morphology of the prepared submicron-sized particles of HECs was investigated thoroughly. The DBD method favors the formation of nanosized particles of RDX and TNT at lower concentrations (5 mM). However, a significant increase in the mean particle size occurred at higher concentrations (25 and 50 mM). Formation of facetted crystals of RDX, HMX, and nanorods of TNT was observed at higher concentrations because of the interaction of crystal facets with the antisolvent. Relatively, smaller sized, spherical particles of RDX and HMX could be prepared through the DTD method even at higher concentrations (25 mM). The DTD method is a continuous process and hence is a facile method for industrial applications. X-ray diffraction and Fourier transform infrared spectroscopy studies revealed that RDX, HMX and TNT were precipitated in their most stable polymorphic forms α, β, and monoclinic, respectively. Differential scanning calorimetry showed that the thermal response of the nano-HECs was similar to the respective raw-HECs. A slight decrease in crystallinity and the melting point was observed because of the decrease in the mean particle size.

show abstract

Section: Resultsmentioning

confidence: 99%

Engineering the Morphology and Particle Size of High Energetic Compounds Using Drop-by-Drop and Drop-to-Drop Solvent–Antisolvent Interaction Methods

2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Antisolvent reprecipitation is widely used nanoformulation technique for organic compounds such as poorly water soluble APIs, polymers, dyes, and pigments . In the antisolvent reprecipitation process, nanoparticles were formed by mixing of the solution of substance with suitable antisolvent under stirring . The simple schematic experimental setup is shown in Figure .…”

Section: Ff Nanoformulation Techniques and Literature Reportsmentioning

confidence: 98%

“…Many techniques feasible to formulate drug nanoparticles with smaller size without any surfactants. But with the absence of surfactant, the stability of particles is poor as it is a common issue have been reported in many nanoformulations techniques with high solid loading and colloidal particle system . Hence, the use of surfactants is highly recommended during the formulation to enhance the stability of nanoparticles.…”

Section: Ff Nanoformulation Techniques and Literature Reportsmentioning

confidence: 99%

See 1 more Smart Citation

Solubility and Bioavailability of Fenofibrate Nanoformulations

Kumar

2020

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

Dedicated to my parents, family, all my teachers and friends.Fenofibrate is a poorly water soluble lipid-regulating drug used to control triglyceride and cholesterol levels in blood plasma. However, due to its poor aqueous solubility, it has poor therapeutic effectiveness. Recently, several approaches based on nanotechnology have been developed to enhance the water solubility, dissolution, bioavailability, and control release of Fenofibrate. However, very few of these innovative formulations have reached the stage of clinical trials and only few have commercialized. Here, we systematically review the techniques such as milling, antisolvent precipitation, sonication, supercritical fluid techniques, electrospray, self-emulsifying drug delivery, lipid-based nanoparticle, and silica nanostructurebased formulation used to enhance bioavailability of Fenofibrate. We have reviewed the progress in Fenofibrate nanoformulations, commercial products, and future challenges for further investigation.[a] Dr.

show abstract

“…PVA is a biodegradable polymer soluble in water, and available in different degrees of hydrolysis, with potential as an antibiofouling nanoparticles (NPs) carrier. Its low toxicity [5] ability to form thin films [6][7][8][9][10] and stabilize nanoparticles [11] are known. However, aqueous media can produce PVA swelling and dissolve it, consequently producing open structures and lowering the continuity of its coatings [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Evaluation of the Antibiofouling Potential of Some Metal and Metal Oxide Nanoparticles

et al. 2020

View full text Add to dashboard Cite

This study explores the potential antibiofouling capacity of coatings based on mixes of poly vinyl alcohol (PVA)-glutaraldehyde (GA) incorporating additions of metal and metal oxide nanoparticles (TiO2, ZnO, CuO, AgNPs and Ag-TiO2NPs). Such a kind of hybrid polymer-nanoparticle mix (PVA/GA/ nanoparticles (NPs)) was uniformly applied by spin coating on the surface of a laboratory raceway and tested in freshwater loaded with green algae communities. The results showed PVA/GA was a convenient carrier for the nanoparticles tested. Image analysis of the coatings showed that Ag-TiO2 nanoparticles exhibited a significant improvement of the antibiofouling effect when compared with that of AgNPs and TiO2-NPs. The effect of the Ag-TiO2 NPs loaded coating about four times better than that of ZnO-NPs. A consistent experimental methodology was developed to test the antibiofouling capacity of the coatings and the hybrid coatings developed have demonstrated promising results as environmentally friendly antibiofouling materials.

show abstract

Preparation and characterization of polyvinyl alcohol stabilized griseofulvin nanoparticles

Cited by 23 publications

References 29 publications

Engineering the Morphology and Particle Size of High Energetic Compounds Using Drop-by-Drop and Drop-to-Drop Solvent–Antisolvent Interaction Methods

Engineering the Morphology and Particle Size of High Energetic Compounds Using Drop-by-Drop and Drop-to-Drop Solvent–Antisolvent Interaction Methods

Solubility and Bioavailability of Fenofibrate Nanoformulations

Synthesis, Characterization and Evaluation of the Antibiofouling Potential of Some Metal and Metal Oxide Nanoparticles

Contact Info

Product

Resources

About