Preparation and characterization of solid lipid nanoparticles loaded traditional chinese medicine

Li, Yingchao; Dong, Lei; Jia, Ai; Chang, Xin-Ming; Xue, Hui

doi:10.1016/j.ijbiomac.2006.03.006

Cited by 70 publications

(39 citation statements)

References 16 publications

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“…Surface of microspheres and nanospheres can be modified to improve their active targeting in vivo and extend their detention time in the blood. With the ultrasonication method was employed to prepare solid lipid nanoparticles (SLN), Li et al (2006) incorporated the model TCM of tetrandrine (TET) into SLN. The TET-loaded SLN (TET-SLN) were spherical with the size of 157.3 ± 8.2 nm.…”

Section: Surface Modification Of Microspheres and Nanospheresmentioning

confidence: 99%

Application of traditional Chinese medicine preparation in targeting drug delivery system

Xing

Dong

et al. 2014

Drug Delivery

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(2015) Application of traditional Chinese medicine preparation in targeting drug delivery system, Drug Delivery, 22:3, 258-265, DOI: 10.3109/10717544.2014 AbstractTargeting drug system (TDS) or targeted drug delivery system (TDDS) is a new kind of drug delivery system which could make drug to be directly concentrated on the target site with high curative effects and low side-effects. As the quintessence of Chinese culture, traditional Chinese medicine (TCM) has a large advantage in many disease clinical treatments, especially in cancer, hypertension and many other intractable diseases owing to their low toxicity and side-effects relative to western medicine. This article reviews literatures on development of TCM-targeted preparations which were published in the past 10 years. TDS including active-targeting, passive-targeting and physical-chemical-targeting preparations were introduced through domestic and overseas literatures to reveal the unique advantages of TCM-targeting preparations in drug delivery system. In this article, we have reviewed some kinds of TCM-targeting preparations and indicated that great attention should be paid to the research on the TCM-targeting preparations.

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Section: Surface Modification Of Microspheres and Nanospheresmentioning

confidence: 99%

Application of traditional Chinese medicine preparation in targeting drug delivery system

Xing

Dong

et al. 2014

Drug Delivery

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“…No.7 step is to do drug effect test, No.8 step is to measure leftover of organic solvent. No.9 is other specific evaluation for nanoscale Chinese medicine [18][19][20][21][22][23][24].…”

Section: Standardization Of Quality Of Nanoscale Chinese Medicine Phamentioning

confidence: 99%

Advance and Prospect of Nanoscale Chinese Medicine

Wu¹

2010

Nano BioMed ENG

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Over the past few years, nanoscale Chinese medicine has emerged as a new exciting field in which theoretical and experimental studies of structure and function of nanoscale Chinese drugs have become a focus, and the importance of quality standardization of nanoscale medicament of Chinese traditional medicine as specific drugs to the fundamental development in traditional Chinese drugs has begun to be recognized. In particular, Chinese medicine dispersion, surface potentials, envelopment ratio, loading drug amounts, in vivo metabolism dynamics, bio-distribution, drug-releasing in vitro, etc., have become a new interdisciplinary frontier in life science and Chinese traditional medicine. There is an increasing need for a more systematic study of the basic issues involved in traditional Chinese medicine and a more active participation of researchers in the application area of nanoscale traditional Chinese drugs. Some advances have been and are being made in nanoscale Chinese herbs, mineral medicine including mongolia drugs such as cinnabar, with enormous prospect in clinical disease therapy. Here we review some of the main advances in this field over the past few years, explore the application prospects, and discuss the concepts, issues, approaches, and challenges, with the aim of stimulating a broader interest in developing nanoscale Chinese medicine.

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“…Delivery of lipophilic natural compounds by SLNs is a promising strategy that has attracted the attention of both phytochemist and pharmaceutical scientist to overcome their poor solubility, and to increase their pharmaceutical behaviors. In this context, fabrication of various active natural compounds such as acetylshikonin (Eskandani & Nazemiyeh, 2014), curcumin (Wang et al, 2012), frankincense and myrrh essential oils (Shi et al, 2012), tetrandrine (Li et al, 2006), and andrographolide (Parveen et al, 2013) in SLNs have been reported until now. Apparently, however, no investigation has been made to deliver galbanic acid (GBA) to the cancerous cells by the SLNs until now.…”

Section: Introductionmentioning

confidence: 99%

Formulation, characterization, and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles

Eskandani

Barar

Dolatabadi

et al. 2015

Pharmaceutical Biology

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Context: Galbanic acid (GBA) is a sesquiterpene coumarin with different medicinal properties and anticancer effects. Objective: To improve the anticancer activities of GBA, in the current study, we aimed to fabricate GBA-loaded solid lipid nanoparticles (GBA-SLNs) and study their biological activities in vitro. Materials and methods: Hot homogenization was used for preparation of GBA-SLNs. The encapsulation efficiency (EE) and drug loading (DL) and in vitro release were determined. MTT, DAPI, DNA fragmentation, comet, and Anexin V apoptosis assays were used to compare the anti-cell proliferation and genotoxicity properties of GBA and GBA-SLNs against A549 cells and HUVEC to detect apoptosis and DNA damage in the final concentration of 100 mM after 48 h treatment. Results: Scanning electron microscopy (SEM) and particle size analysis showed spherical SLNs (92 nm), monodispersed distribution, and zeta potential of À23.39 mV. High EE (498%) and long-term in vitro release were achieved. The stability of GBA-SLNs in aqueous medium was approved after 3 months in terms of size and polydispersity index. GBA was able to inhibit A549 growth with an IC 50 value of 62 mM at 48 h. Although GBA-SLNs could also inhibit the growth rate of A549 cells, the effect is perceived after 48 h, as approved by the quantitative expression of Bcl-xL and Casp 9 genes, and also genotoxicity assays. Conclusion: Long-term apoptotic effect of GBA-SLNs compared with GBA may be due to the accumulation of GBA-SLNs in the tumor site because of deviant tumor pathology. Our data confirmed that SLNs could be exploited for sustained lipophilic GBA delivery.

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Preparation and characterization of solid lipid nanoparticles loaded traditional chinese medicine

Cited by 70 publications

References 16 publications

Application of traditional Chinese medicine preparation in targeting drug delivery system

Application of traditional Chinese medicine preparation in targeting drug delivery system

Advance and Prospect of Nanoscale Chinese Medicine

Formulation, characterization, and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles

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