Preparation and characterization of stable fluorescent As4S4/ZnS/Fe3O4 nanosuspension capped by Poloxamer 407 and folic acid

Equimolar As4S4/Fe3O4 Nanocomposites Fabricated by Dry and Wet Mechanochemistry: Some Insights on the Magnetic–Fluorescent Functionalization of an Old Drug

“…Such media control both (i) the energy transfer towards the substance undergoing nanostructurization and (ii) the energy re-transfer between NPs within the nanocomposite [30]. As was shown recently [18,23,24], the nanostructurizationamorphization balance could be essentially disturbed in arsenical-bearing nanocomposites enriched in finest ZnS NPs, contributing to outer shells around greater crystallites. In these grinding media, the amorphous phase generated under continuous MM was of the same chemistry (originated from principal constituents of the nanocomposite), while the contamination effects from milling facilities could not be excluded, especially under wet-chemistry conditions.…”

“…The crystallographic specificity of the fabricated nanocomposites was recognized by X-ray powder diffraction (XRPD) analysis [20][21][22][23][24]. The data were collected via the transmission mode of the STOE STADI P diffractometer (STOE & Cie GmbH, Darmstadt, Germany) with a linear position-sensitive detector (the curved Ge(111) monochromator), using Cu-Kα1 radiation.…”

“…In arsenical-bearing MNP systems, a nanoarsenical functionalized as the anticancer drug is often used in combination with other compounds to emerge as pharmaceuticals possessing a lot of advantages, such as fluorescence emission due to ZnS [15,16] or a magnetically addressable drug delivery ability due to Fe 3 O 4 [17]. This approach allows functionally-compositionally inter-balanced MNP systems, like biparticulate dualfunctionalized nanocomposites (e.g., anticancer-fluorescent As 4 S 4 /ZnS [18,19], or anticancermagnetic As 4 S 4 /Fe 3 O 4 [20][21][22]), and/or triparticulate triple-functionalized nanocomposites (e.g., anticancer-fluorescent-magnetic As 4 S 4 /ZnS/Fe 3 O 4 [23,24]). From a purely medical point of view, what seems especially attractive is the ability to perform a few functions by one type of NP in a whole nanocomposite formulation, as expected for nanoarsenicals functionalized as quantum-confined solid fluorophores in addition to their anticancer therapeutic effect.…”

“…Such a bimodal "two-in-one" functionalization foresees the surface passivation of arsenical NPs, which contribute to the non-radiative recombination from the surface states of dangling bonds (DBs), like in other nanostructured substances [25]. Noteworthily, NPs with non-passivated surfaces (stabilized in the MNP systems without surfactants) are prone to quick agglomeration and oxidation, thereby missing with time a size-limiting requirement for a quantum confinement effect (QCE) [12,[24][25][26].…”

SDS-Stabilized CuInSe2/ZnS Multinanocomposites Prepared by Mechanochemical Synthesis for Advanced Biomedical Application

“…Its potential toxicity is also a subject to research [20,21]. At the final stage, the top-down approach employing high-energy mechanochemical synthesis in wet stirred media can be used to produce nanosuspensions, as it was noted in a number of recent publications [15,17,[22][23][24][25][26].…”