Preparation and Characterization of Thalidomide
Hyroxy Propyl  -Cyclodextrin Inclusion Complex

Metilda, G. Mary; Kumari, J. Prema

doi:10.29055/jccs/613

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“…Previously, a similar kind of inclusion complexation studies has been done by Meltida and Kumari and Wang et al with UMB and βCD as well as HP-α-CD. 25,26 Herein, we have designed three different inclusion complexes and, thereafter, different kinds of characterization techniques have been applied to check the formation of the inclusion complex. In this study, we report the synthesis and characterization of the UMB + αCD inclusion complex and our main objective was to determine the influence of complexation with αCD in improving thermal stability as well as photostability (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body

et al. 2020

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In this study, umbelliferone and α-cyclodextrin host molecules have been mixed up through a coprecipitation method to prepare a supramolecular complex to provide physical insights into the formation and stability of the inclusion complex (IC). The prepared hybrid was characterized by 1H nuclear magnetic resonance (1H NMR), Fourier transform infrared (FTIR) spectroscopy, electrospray ionization (ESI) mass spectrometry, DSC, and fluorescence spectroscopic studies. Job’s plot provides a stoichiometric ratio of 1:1 and the Benesi–Hildebrand double reciprocal plot gives binding constant values using fluorescence spectroscopic titrations and the ESI mass data support the experimental observations. The results of molecular modeling were systematically analyzed to validate the inclusion complexation. In preliminary computational screening, α-cyclodextrin IC of umbelliferone was found to be quite stable based on the docking score, binding free energies, and dynamic simulations. In addition, the results obtained from 1H NMR and FTIR spectroscopy studies supported the inclusion complexation phenomenon. The results obtained from computational studies were found to be consistent with the experimental data to ascertain the encapsulation of umbelliferone into α-cyclodextrin.

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Section: Introductionmentioning

confidence: 99%