Preparation and Characterization of the Molybdenum Disulfide Nanosheets Coated with Poly‐(NVCL‐co‐AGE))/MA for the Anticancer Drug Delivery Light

Abstract

A novel thermosensitive polymer (poly-(NVCL-co-AGE))/MA was synthesized by N-vinylcaprolactam (NVCL), 5-Amino-2-hydroxybenzoic acid (Mesalamine, MA) and allyl glycidyl ether (AGE). The obtained polymeric matrix is functionalized on molybdenum disulfide nanosheets (MNs (which is used as a drug carrier for efficient drug delivery. The ability of MNs -(poly-(NVCL-co-AGE))/MA was estimated as a nanocarrier for the delivery of imatinib mesylate (IM) as an antitumor drug. The resulting polymer was confirmed by FESEM/EDX, TEM, XRD, FTIR, TGA, and UV-Vis spectroscopy. The impacts of various variables such as pH, contact time, and temperature on the adsorption efficiency were also evaluated. Kinetic and isotherm studies of IM adsorption demonstrated that the adsorption of IM on the surface of MNs -(poly-(NVCL-co-AGE))/MA was well fitted to the pseudo-second-order kinetic and Langmuir isotherm mod-els, respectively. On the other hand, we were interested in estimating drug release kinetics and in vitro release behavior of IM loaded on MNs -(poly-(NVCL-co-AGE))/MA. In vitro controlled drug release and phototherapy under near-infrared (NIR) light irradiation are also discussed. The existence of absorbed NIR energy causes shrinkage of thermo-sensitive polymer chains and successfully caused the drug release. In vitro drug release of MNs -(poly-(NVCL-co-AGE))/MA was comparatively carried out at 37 and 50°C. The release rate of MNs -(poly-(NVCL-co-AGE))/MA at 50°C was much higher than those at 37°C. Also, the drug release behavior after the involvement of NIR light irradiation reached up to 98 % over 15 min, which was about 11 times that without NIR light irradiation.