Preparation and cytotoxic properties of goethite‐based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide

Iron oxide‐based magnetic nanostructures bearing cytotoxic organosilicon molecules for drug delivery and therapy

“…[33] Repeated treatment of magnetic organic solutions 2 (Fe 3 O 4 -A1), 3 (Fe 3 O 4 -A3 S ) and 4 (FeOOH-OA) with A1 or A3 resulted in preparation of MFs of double-layered nanoparticles 13 (Fe 3 O 4 -A1-A1),14 (Fe 3 O 4 -A3 S -A3) and 15 (FeOOH-OA-A1). [34,35] Nanoparticle composition in organic solutions 1, 4 and 7-15 was determined in the corresponding powders 5, 6 and 16-24, obtained from organic solutions after treatment of the latter with acetone ( Table 1).…”

“…The rough estimation of nanoparticles average size gave the value of 80 Å ′ (8 nm). [35] Magnetic properties of goethite remain difficult to interpret. It has been reported in the literature that they are strongly affected by the particle size degree of crystallinity and temperature.…”

“…They display superparamagnetism which is equivalent to superparamagnetism of magnetite nanoparticles with corresponding concentration and corresponding size determined for each sample: 0.037 emu g −1 for 6 (FeOOH-OA) and 0.106 emu g −1 for 24 (FeOOH-OA-A1). [35] The yield of water-soluble powdery samples 35-39 (Fe 3 O 4 -OA-A1 to A5), containing alkanolamines A1-A5, 34 (Fe 3 O 4 -OA) and 40 (FeOOH-OA-A1) ranges within 9-52, 5-21 and 73%, respectively (Table 2). [32 -35] The magnitude of magnetization and magnetite concentration of water-soluble powders were calculated on the basis of the same parameters obtained for the corresponding water solutions.…”

“…There is a difference from the sizes obtained by means of magnetogranulometry because of the molecular or ion shell on ferrite particles in colloidal solution and, probably, association of some ferrite particles on one colloidal particle takes place. [35] As an example, the magnetization curves and size distribution of mixed covered nanoparticles ( …”

“…[34] The aqueous solution of goethite nanoparticles 33 (FeOOH-OA-A1) revealed cytotoxicity, which approximated to the less active analogous magnetite-based sample from a series of 26 (Fe 3 O 4 -OA-A1), and possessed moderate NO induction ability. [35] All the tested water-based magnetic solutions 26-30 (Fe 3 O 4 -OA-A1 to A5), containing silyl alkanolamines (A1-A5), had a strong effect on tumor cell morphology, either mouse hepatoma or human fibrosarcoma. Tumor cells had a tendency to form colonies.…”