2018
DOI: 10.1007/s42235-018-0055-3
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Preparation and Endothelialization of Multi-level Vessel-like Network in Enzymated Gelatin Scaffolds

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Cited by 6 publications
(4 citation statements)
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“…The most recent development in hydrogel scaffolds was the fabrication of multi-level vessel-like networks in the enzymatic gelatin hydrogels. The branched and multi-level microchannel network developed by Dong et al [ 113 ] simulates biomimetic microenvironments of the cellular ECM that effectively and efficiently promote tissue regeneration. The network construct exhibits great promise in developing ECM and organ assisting devices in muscle regeneration as the nutrients and oxygens can be easily supplied to the cells via microfluidic vascular.…”
Section: Engineered Natural Polymeric Scaffolds For Muscle Regenermentioning
confidence: 99%
See 1 more Smart Citation
“…The most recent development in hydrogel scaffolds was the fabrication of multi-level vessel-like networks in the enzymatic gelatin hydrogels. The branched and multi-level microchannel network developed by Dong et al [ 113 ] simulates biomimetic microenvironments of the cellular ECM that effectively and efficiently promote tissue regeneration. The network construct exhibits great promise in developing ECM and organ assisting devices in muscle regeneration as the nutrients and oxygens can be easily supplied to the cells via microfluidic vascular.…”
Section: Engineered Natural Polymeric Scaffolds For Muscle Regenermentioning
confidence: 99%
“… Culture of the cells in a vessel-like network ( a ). Model predefined microchannels, ( b – d ) phase images of cell morphology inside three-level channels after cultivation for four days, seven days and 14 days [ 113 ]. Reprinted by permission of springer Nature.…”
Section: Figurementioning
confidence: 99%
“…Coaxial focused wrapping technology has also been applied in the 3D printing of extrusion molding for the forming and manufacturing of vascular structures. The extrusion molding 3D printing methods all adopt coaxial focusing printing methods, such as "dual-material synchronous extrusion" [16,17] and "micro-channel extrusion" [18,19], to realize the printing and molding of the vessel structure. However, because the density and uniformity of cells in the vessel-like structure are mainly determined by the density and uniformity of cells in the biological materials, it is not easy to meet the requirements of cell microsphere shaping and printing-on-demand.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, it is an urgent problem to design and construct multi-stage and multi-size bionic micro-channels within large tissue engineering scaffolds because the bloods in the vascular network can nutrient ambient cells. In our previous study, a multi-level and multi-size bionic vascular network was molded by mould [1,2]. The bionic structure could promote cells endothelialization but the preparation process was complex and the precision was very low.…”
Section: Introductionmentioning
confidence: 99%