Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System

Donthi, Mahipal Reddy; Dudhipala, Narendar; Komalla, Devendhar Reddy

doi:10.4172/jbb.1000254

Cited by 15 publications

(5 citation statements)

References 3 publications

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“…In order to obtain the APIs solid-liquid phase diagrams, the DSC characterization was performed. The corresponding DSC curves ( Figure 2 ) show only the melting processes of APIs: Ibuprofen at 348.4 ± 0.2 K, Ketoprofen at 367.5 ± 0.2 K, and Drotaverine Hydrochloride at 488.4 ± 0.4 K. These experimental data are in accordance with literature data [ 18 , 19 , 20 ].…”

Section: Resultssupporting

confidence: 88%

“…The activity coefficient of a component i present in the eutectic melt, neglecting the difference in heat capacity of the liquid and solid phases, can be calculated from equation [ 18 ]:

where

and T fus , i are the mole fraction, activity coefficient, heat of fusion, and the melting temperature of component i , R is the gas constant, and T is the liquidus temperature.…”

Section: Methodsmentioning

confidence: 99%

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Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

et al. 2022

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Formulations with two or more active pharmaceutical ingredients (APIs) are a researched trend due to their convenient use compared with multiple medications. Moreover, drug-drug combinations may have a synergistic effect. Drotaverine hydrochloride (D-HCl) is commonly used for its antispasmodic action. The combination of a spasmolytic and an analgesic drug such as ibuprofen (Ibu) or ketoprofen (Ket) could become the answer for the treatment of localized pain. D-HCl:Ibu and D-HCl:Ket drug-drug interactions leading to the formation of eutectic compositions with increased bioavailability, obtained by mechanosynthesis, a green, solvent-free method was explored for the first time. The compatibility of Ibuprofen, Ketoprofen, and Drotaverine Hydrochloride was investigated using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier-Transform Infrared spectroscopy (FTIR). Solid-liquid equilibrium (SLE) phase diagrams for the binary systems of active pharmaceutical ingredients were developed and the Tammann diagrams were designed to determine the eutectic compositions. The excess thermodynamic functions GE for the pre-, post-, and eutectic compositions were obtained using the computed activity coefficients data. Results show that drotaverine-based pharmaceutical forms for pain treatment may be obtained at 0.9 respectively 0.8 molar fractions of ibuprofen and ketoprofen which is advantageous because the maximum allowed daily dose of Ibu is about 6 times higher than those of D-HCl and Ket. The obtained eutectics may be a viable option for the treatment of pain associated with cancer therapy.

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Section: Resultssupporting

confidence: 88%

“…The activity coefficient of a component i present in the eutectic melt, neglecting the difference in heat capacity of the liquid and solid phases, can be calculated from equation [ 18 ]:

where

and T fus , i are the mole fraction, activity coefficient, heat of fusion, and the melting temperature of component i , R is the gas constant, and T is the liquidus temperature.…”

Section: Methodsmentioning

confidence: 99%

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

et al. 2022

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“…About 4 mg of the sample was taken in an aluminum crucible using dry nitrogen as the inert gas. The heating range was programmed to 20–300 °C, with a heating rate of 10 °C/min for analyzing each sample [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

et al. 2023

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The current study aimed to develop a topical emulgel of dasatinib (DTB) for rheumatoid arthritis (RA) treatment to reduce systemic side effects. The quality by design (QbD) approach was employed to optimize DTB-loaded nano-emulgel using a central composite design (CCD). Emulgel was prepared using the hot emulsification method, and then the particle size (PS) was reduced using the homogenization technique. The PS and % entrapment efficiency (% EE) were found to be 172.53 ± 3.33 nm (0.160 ± 0.014 PDI) and 95.11 ± 0.16%, respectively. The nano-emulsion (CF018 emulsion) in vitro drug release profile showed sustained release (SR) up to 24 h. MTT assay results from an in vitro cell line study revealed that formulation excipients had no effect, whereas emulgel showed a high degree of internalization. Furthermore, emulgel treatment significantly reduced LPS-induced TNF-α production in RAW 264.7 cells. The spherical shape was depicted in FESEM images of optimized nano-emulgel (CF018 emulgel) formulation. Ex vivo skin permeation was significantly increased when compared to the free drug-loaded gel (FDG). In vivo data revealed that the optimized CF018 emulgel is a non-irritant and is safe. In terms of paw swelling, the FCA-induced arthritis model demonstrated that the CF018 emulgel reduced paw swelling percentage compared to adjuvant-induced arthritis (AIA) control group. Following clinical testing in the near future, the designed preparation could be a viable alternative treatment for RA.

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“…The HLB value of the surfactant is an important variable for selecting the proper surfactant. The surfactants are either w/o type (HLB of [3][4][5][6][7][8] or o/w type (HLB of 8-16). In w/o emulsions, low HLB value surfactants i.e., less than 8 are utilized.…”

Section: Surfactant Systemmentioning

confidence: 99%

“…Despite of employing various technologies for enhancing the solubility, delivering the drugs via the oral route is not always feasible owing to their low bioavailability associated with poor absorption, first-pass metabolism, chemical and enzymatic degradation [ 5 , 6 ]. In addition, clinical complications and low concentrations of the drug at the site of action hinder drug delivery through the oral route.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

et al. 2023

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Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of different systems aims to deal with these limitations. The novel system prepared by the incorporation of nano-emulsion into gel improves stability and enables drug delivery for both immediate and controlled release. The focus on nano-emulgel has also increased due to its ability to achieve targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review focuses on the formulation components of nano-emulgel for topical drug delivery, pharmacokinetics and safety profiles.

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Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System

Cited by 15 publications

References 3 publications

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

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