Preparation and Evaluation of Orally Disintegrating Tablets of Drotaverine Hydrochloride Using Sublimation Technique

Hari, Kuralla; Rajeswari, Saripilli; Ramanamurthy, K. V.

doi:10.22159/ijpps.2018v10i5.24503

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…The time for the tablet to completely disintegrate into fine particles was determined. Three tablets from each formulation were tested, and results were expressed in seconds [5,6].…”

Section: In Vitro Dispersion Time Testmentioning

confidence: 99%

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Formulation, Optimization, and Evaluation of Sitagliptin and Simvastatin Rapidly Dissolving Tablets

Bayoumi¹

2018

Int J App Pharm

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Objective: The scope of this work was to formulate sitagliptin and simvastatin rapidly dissolving tablets. However, simvastatin is practically insoluble in water. For improving its poor oral bioavailability and with the aim of facilitating administration to patients facing problems with swallowing rapidly dissolving tablets were preparedMethods: Tablets were prepared using superdisintegrant addition technique using croscarmellose sodium (Ac-di-sol), sodium starch glycolate (explotab) and crospovidone in different percentages. Evaluation tests such as weight variation, thickness, and content variation, and friability, disintegration, wetting time, in vitro dispersion and in vitro dissolution were carried out.Results: The results showed that the presence of crospovidone could enhance the dissolution rate of simvastatin greatly. The best-optimized formulae found were that F8, F9, and F10 which showed good disintegration and the dissolution rate of simvastatin and sitagliptin was more than 90% after 10 min while the dissolution rate for simvastatin and sitagliptin pure standards was 12% and 30%, respectively after 10 min.Conclusion: Some tablet formulae showed acceptable pharmacotechnical properties and complied with compendium requirements. Results of dissolution studies revealed that F8-F10 showed an increase in the dissolved sitagliptin and simvastatin to be more than 90% after 10 min.

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“…The time for the tablet to completely disintegrate into fine particles was determined. Three tablets from each formulation were tested, and results were expressed in seconds [5,6].…”

Section: In Vitro Dispersion Time Testmentioning

confidence: 99%

“…A tablet was carefully placed on the surface of the tissue paper. The time required for water to reach the uppermost surface of the tablet was determined [6].…”

Section: Wetting Timementioning

confidence: 99%

Formulation, Optimization, and Evaluation of Sitagliptin and Simvastatin Rapidly Dissolving Tablets

Bayoumi¹

2018

Int J App Pharm

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“…Thus, famotidine is better option for the development of immediate release tablets [5,6]. The purpose of the present research work was to develop and characterize immediate release tablets of famotidine using various synthetic superdisintegrants such as crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycolate (SSG) with mannitol to release the medicament and mask bitter taste [7][8][9]. Fasting dissolving tablets (FDTs) helps in immediate release of medicament, leading to an increase in bioavailability of the drug and quick onset of pharmacological action can take place [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Famotidine Fast Dissolving Tablets Using Synthetic Superdisintegrants

Rajeswari

Kumari

2019

Int J Pharm Pharm Sci

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Objective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern. Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies. Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy). Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05).

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Design and Statistical Optimization of Concentration of Sublimating Agents in Formulating Orodispersive Tablets

Avasarala,

Nokku,

Pabbineedi

et al. 2023

IND. DRU.

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Amlodipine is a BCS (biopharmaceutical Classification System) class I drug with high permeability and high solubility. It has a long half-life of 30-50h. It is a suitable model drug for formulating orodispersive tablets, as the orodispersive tablets can release the drug immediately. thus, formulation of amlodipine into orodispersible tablets will help in improved delivery of the drug at a faster rate. to achieve this, the orodispersive tablets were prepared by sublimation technique and the concentration of the sublimating agents was optimized by central composite design. based on the results, it was concluded that camphor and thymol when used at optimum concentrations can be used in the formulation of orodispersive tablets, the drug delivery systems for drugs with long half-life. they are potential delivery systems to improve palatability also for model drugs like amlodipine.

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Preparation and Evaluation of Orally Disintegrating Tablets of Drotaverine Hydrochloride Using Sublimation Technique

Cited by 3 publications

References 7 publications

Formulation, Optimization, and Evaluation of Sitagliptin and Simvastatin Rapidly Dissolving Tablets

Formulation, Optimization, and Evaluation of Sitagliptin and Simvastatin Rapidly Dissolving Tablets

Formulation and Evaluation of Famotidine Fast Dissolving Tablets Using Synthetic Superdisintegrants

Design and Statistical Optimization of Concentration of Sublimating Agents in Formulating Orodispersive Tablets

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