2018
DOI: 10.13188/2327-204x.1000027
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Preparation and Evaluationof Ibuprofen Solid Dispersion Tablets with Improved Dissolution and Less Sticking Using Porous Calcium Silicate

Abstract: The aim of this study was to prepare and evaluate Ibuprofen (IBU) solid dispersion tablets with improved dissolution and less sticking using Porous Calcium Silicate (PCS). Solid dispersion granules were prepared using water-based solid dispersion and water-retained PCS with the wet granulation method and a high-speed agitation granulator. We attempted to use four binders [Hydroxypropylcellulose (HPC), dextrin, maltitol, and xylitol] to prepare the granules; however, HPC could not be used. After 1h of continuou… Show more

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