Preparation and <i>in vitro</i> evaluation of melatonin-loaded HA/PVA gel formulations

Tanrıverdi, Sakine Tuncay; Cheaburu-Yılmaz, Catalina Natalia; Carbone, Sonia; Özer, Özgen

doi:10.1080/10837450.2016.1268158

Cited by 25 publications

(13 citation statements)

References 38 publications

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“…The first successful use for periodontal disease topical treatment was proved by Pagnacco and co-workers in 1997, in a clinical trial vs placebo, exploring the antiinflammatory, anti-edematous, and anti-bacterial effects of HA [45]. Moreover, high level of natural HA are present in serum all fluid samples examined of gingival crevicular fluid (GCF), regarded as a serum-derived product, but absent in GCF samples from patients with acute necrotizing ulcerative gingivitis [10]. It reappears after effective antibacterial treatment with consequently reducing the bacterial hyaluronidase activity [11], proving that HA could be considered as marker for active disease [12].…”

Section: Biological Actionsmentioning

confidence: 99%

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Melatonin and Hyaluronic Acid in Periodontal Disease

Cristache¹,

Totu²,

Cristache³

et al. 2019

Rev. Chim.

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The aim of the present paper was to highlight the individual effects of melatonin (MEL) and hyaluronic acid (HA) on periodontal structures and repair mechanism and to investigate a possible synergic effect and if each component of the proposed mixture (MEL-HA) would maintain their specific characteristics, when using booth active principles, for a topical application. A comprehensive review of the recent literature focusing on the role of MEL and HA in periodontal therapy, as well as on the use of both active compounds and possible synergic effect, have been conducted. An experimental investigation, using the FT-IR analysis, both the individual spectra of each component and the complex matrix obtained was performed. The experimental data obtained from our study proved that no structural changes occurred at the level of the functional groups of the components. Therefore, it is expected that the obtained formulation to be highly efficient for the treatment of periodontal disease, as it would combine the specific local action of MEL and HA.

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Section: Biological Actionsmentioning

confidence: 99%

“…A significant number of clinical studies were performed using either hyaluronic acid (HA) or melatonin (MEL) as adjunctive therapy after scaling and root planning (SRP) in periodontal compromise patients. But the effect of combining MEL and HA in a complex active compound was insufficient investigated [9,10].…”

mentioning

confidence: 99%

Melatonin and Hyaluronic Acid in Periodontal Disease

Cristache¹,

Totu²,

Cristache³

et al. 2019

Rev. Chim.

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“…Hydrogels with their three-dimensional, polymeric network have found numerous applications due to their unique properties, such as high water content, softness, flexibility, biocompatibility and ease of preparation. [8][9][10] Mucoadhesive hydrogels have been shown to prolong both the retention times on the mucosal area and the drug release. 11,12 The present paper deals with the preparation and characterization of interpolymeric complexes based on alginate and chitosan that can be used as carrier of Nystatin in mucosal delivery.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Rençber¹,

Cheaburu-Yılmaz²,

Köse³

et al. 2019

Cellulose Chem. Technol.

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Interpolymeric complexes (IPCs) have the advantage of combined properties of their constituent polymers. They are easy to prepare under mild conditions and do not require high processing costs. The interpolymeric complexes of alginate, chitosan and Nystatin, as antifungal drug systems, represent an alternative for mucosal illness treatment. The composition of the two polymers is a key parameter in obtaining the desired properties for pharmaceutical formulations. IPCs of sodium alginate (SA) and chitosan (CS) were prepared via solution mixing method with various compositions, followed by coacervation in 2-propanol. The outcome obtained from rheological measurements was that the complex SA/CS 60/40 (v/v %) fulfilled the requirements of a semi-solid formulation, e.g. pseudoplasticity. Nystatin showed very good compatibility with the polymeric system. The drug loaded gels showed better rheological, textural and mechanical properties (e.g. pseudoelasticity, spreadability, surface adhesion etc.). The final gel formulations showed no cytotoxic effects in the cell culture assay.

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“…However, a more compact structure with smaller pore size was observed on the HA-added poloxamer gel, which may reflect the strong interaction between HA and poloxamer micelles. The compact porous structure also explains the high swelling rate of P407/HA gels which was observed in the first 3 hours during the gel dissolution [38]. This finding not only provides a good explanation of the slower erosion of P407/HA gels, but also reveals the strong physical interactions between the two polymers [39].…”

Section: Plos Onementioning

confidence: 54%

Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA/P407 hydrogel system for drug delivery

et al. 2020

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Pleural empyema is an inflammatory condition characterized by accumulation of pus inside the pleural cavity, which is usually followed by bacterial pneumonia. During the disease process, the pro-inflammatory and pro-fibrotic cytokines in the purulent pleural effusion cause proliferation of fibroblasts and deposition of extracellular matrix, which lead to fibrin deposition and fibrothorax. Urokinase instillation therapy through a chest drainage tube is frequently used for fibrinolysis in patients with empyema. However, urokinase treatment requires multiple instillation (2-3 times per day, for 4-8 days) and easily flows out from the chest drainage tube due to its high water solubility. In this in vitro study, we developed a thermo-responsive hydrogel based on poloxamer 407 (P407) combined with hyaluronic acid (HA) for optimal loading and release of urokinase. Our results show that the addition of HA to poloxamer gels provides a significantly more compact microstructure, with smaller pore sizes (**p < 0.001). The differential scanning calorimetry (DSC) profile revealed no influence on the micellization intensity of poloxamer gel by HA. The 25% poloxamer-based gel was significantly superior to the 23% poloxamer-based gel, with slower gel erosion when comparing the 16th hour residual gel weight of both gels (*p < 0.05; **p < 0.001). The 25% poloxamer-HA gel also exhibited a superior urokinase release profile and longer release time. A Fourier-transform infrared spectroscopy (FT-IR) study of the P407/HA hydrogel showed no chemical interactions between P407 and HA in the hydrogel system. The thermoresponsive P407/HA hydrogel may have a promising potential in the loading and delivery of hydrophilic drugs. On top of that, in vitro toxicity test of this combination demonstrates a lower toxicity. PLOS ONEPLOS ONE | https://doi.org/10., et al. (2020) Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA/P407 hydrogel system for drug delivery. PLoS ONE 15(3): e0227784. https://doi.org/10.

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Preparation and in vitro evaluation of melatonin-loaded HA/PVA gel formulations

Cited by 25 publications

References 38 publications

Melatonin and Hyaluronic Acid in Periodontal Disease

Melatonin and Hyaluronic Acid in Periodontal Disease

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA/P407 hydrogel system for drug delivery

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