Preparation and <i>in vitro</i> release kinetics of nitrendipine-loaded PLLA–PEG–PLLA microparticles by supercritical solution impregnation process

Zhan, Shu‐Zhong; Wang, Jingchang; Wang, Weijing; Cui, Liyun; Zhao, Qian

doi:10.1039/c9ra01068h

Cited by 41 publications

(19 citation statements)

References 35 publications

(27 reference statements)

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“…PLA is a synthetic biopolymer belonging to the family of aliphatic polyesters that has been extensively used for the supercritical impregnation of bioactive compounds [ 12 ]. PLA foams have been employed for the supercritical impregnation of cinnamaldehyde [ 13 ], and thymol [ 14 , 15 ]; it was also employed for the loading of aspirin in film form [ 16 ] and as a particle it was used for nitrendipine [ 17 ], ketoprofen and carvone [ 18 ], diclofenac [ 19 ], dihydroquercetin and α-tocopheryl succinate [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications

et al. 2022

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The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO2 (scCO2), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable filaments of thermoplastic polyurethane (TPU) and polylactic acid (PLA) were employed for the supercritical impregnation of ethanolic olive leaves extract (OLE) for biomedical application. The extraction of OLE was performed using pressurized liquids. The effect of pressure (100–400 bar), temperature (35–55 °C), and the polymer type on the OLE impregnation and the swelling degree were studied including a morphological analysis and the measurement of the final antioxidant activity. All the studied variables as well as their interactions showed significant effects on the OLE loading. Higher temperatures favored the OLE loading while the pressure presented opposite effects at values higher than 250 bar. Thus, the highest OLE loadings were achieved at 250 bar and 55 °C for both polymers. However, TPU showed c.a. 4 times higher OLE loading and antioxidant activity in comparison with PLA at the optimal conditions. To the best of our knowledge, this is the first report using TPU for the supercritical impregnation of a natural extract with bioactivity.

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Section: Introductionmentioning

confidence: 99%

Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications

et al. 2022

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“…The n value is an exponent that describes the release kinetics process 13 . It was smaller than 0.45 for all concentrations of CA + Vit.D 3 , indicating that the drug was released from CA + Vit.D 3 predominantly via the Fickian diffusion mechanism under swollen conditions (i.e., when the pores of the nanofibrous mat were filled with water) 62,63 …”

Section: Resultsmentioning

confidence: 99%

Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Wsoo

Razak

Shahir

et al. 2021

Polymers for Advanced Techs

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Implantable drug delivery systems (IDDSs) play a vital role in treating chronic diseases by reducing dosing frequency and enhancing drug efficacy due to targeted delivery. In the present study, an IDDS was developed from electrospun cellulose acetate (CA) and polycaprolactone (PCL) nanofiber membranes. The implant core consists of a drug‐loaded CA nanofiber (CA + Vit.D3) enclosed in a rate limiting of the PCL membrane (CA + Vit.D3/PCL). The CA and PCL nanofibrous membranes were characterized using a scanning electron microscope (SEM), Fourier transform infrared spectroscopy, X‐ray diffraction, and UV–Vis spectroscopy. This research also investigated in‐vitro cytotoxicity and whether the PCL membrane prolonged drug delivery or led to enhanced mechanical properties. A smooth, beadless surface morphology was observed with fiber diameters of 325 ± 101 nm and 333 ± 79 nm for CA and PCL, respectively. In‐vitro drug release and tensile testing showed that surrounding the core's implants with a PCL membrane improved mechanical properties and kinetic drug release. The modulus and tensile strength of CA + Vit.D3/PCL were 161 ± 14 and 13.07 ± 2.5 MPa, respectively—these values were significantly higher than those obtained for CA + Vit.D3 (132 ± 52 MPa and 8.16 ± 2.36 MPa, respectively). The drug release pattern exhibited by CA + Vit.D3 was burst release, which fits the first‐order kinetic model. In contrast, CA + Vit.D3/PCL exhibited slow drug release, which fits the zero‐order kinetic model. In conclusion, based on the outcomes and facility of the technologies outlined in this article, electrospun CA and PCL nanofibers are suitable for developing long‐term IDDSs.

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“…where a and k are kinetic constants and n is a descriptive parameter of the diffusive release [49]. Before testing the PCL membranes, the cell viability was assessed using the MeWo cell line cultured with different concentrations of the free metallic complexes.…”

Section: Release Profilesmentioning

confidence: 99%

Electrospun Membranes Designed for Burst Release of New Gold-Complexes Inducing Apoptosis of Melanoma Cells

Guadagno

Raimondo

Vertuccio

et al. 2022

IJMS

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Two non-commercial metallic Au-based complexes were tested against one of the most aggressive malignant melanomas of the skin (MeWo cells), through cell viability and time-lapse live-cell imaging system assays. The tests with the complexes were carried out both in the form of free metallic complexes, directly in contact with the MeWo cell line culture, and embedded in fibers of Polycaprolactone (PCL) membranes produced by the electrospinning technique. Membranes functionalized with complexes were prepared to evaluate the efficiency of the membranes against the melanoma cells and therefore their feasibility in the application as an antitumoral patch for topical use. Both series of tests highlighted a very effective antitumoral activity, manifesting a very relevant cell viability inhibition after both 24 h and 48 h. In the case of the AuM1 complex at the concentration of 20 mM, melanoma cells completely died in this short period of time. A mortality of around 70% was detected from the tests performed using the membranes functionalized with AuM1 complex at a very low concentration (3 wt.%), even after 24 h of the contact period. The synthesized complexes also manifest high selectivity with respect to the MeWo cells. The peculiar structural and morphological organization of the nanofibers constituting the membranes allows for a very effective antitumoral activity in the first 3 h of treatment. Experimental points of the release profiles were perfectly fitted with theoretical curves, which easily allow interpretation of the kinetic phenomena occurring in the release of the synthesized complexes in the chosen medium.

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Preparation and in vitro release kinetics of nitrendipine-loaded PLLA–PEG–PLLA microparticles by supercritical solution impregnation process

Abstract: In this work, drug-loaded polymer microparticles were prepared by a supercritical solution impregnation (SSI) process with nitrendipine as the model drug and PLLA–PEG–PLLA as the drug carrier.

Cited by 41 publications

References 35 publications

Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications

Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications

Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Electrospun Membranes Designed for Burst Release of New Gold-Complexes Inducing Apoptosis of Melanoma Cells

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