Preparation and in vitro Evaluation of Inclusion Complexes of Nelfinavir with Chemically Modified ?-cyclodextrins

Hiremath, S. N.; Godge, Ganesh Raosaheb

doi:10.3329/dujps.v11i2.14558

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…These systems especially EE15 tablets seem to be promising systems for delivery of drugs to the colon in case of chronological disorders. [25][26][27][28]…”

Section: Resultsmentioning

confidence: 99%

Development and evaluation of colon targeted drug delivery system by using natural Polysaccharides/Polymers

Godge

Hiremath²

2015

Dhaka Univ. J. Pharm. Sci

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Colon is being extensively investigated as a drug delivery site. This study contains comparison of the usual enteric coating polymers viz. xanthan gum, guar gum, chitosan and ethyl cellulose, as carriers for colon specific drug delivery. Lactose based metoprolol succinate tablets were prepared. These were coated with one of the coating polymers to a varying coat thickness. Tablets were prepared using polysaccharides or synthetic polymer as binders. These included xanthan gum, guar gum, chitosan and ethyl cellulose. Metoprolol Succinate was used as a model drug. The prepared tablets were enteric coated with kollicoat MAE 100 DP to give protection in the stomach. The coated tablets were tested in-vitro for their suitability as colon specific drug delivery systems. The drug release studies were carried out in simulated stomach environment (pH 1.2) for 2 h followed by small intestinal environment at pH 6.8. The dissolution data obtained from tablets demonstrates that the dissolution rate of the tablet is dependent upon the type and concentration of polysaccharide/polymer used as binder. The results demonstrate that enteric coated tablets containing 3% chitosan as a binder, showed only 12.5% drug release in the first 5 h, which is the usual upper gastrointestinal transit time, whereas, tablets prepared using guar gum as binder, were unable to protect drug release under similar conditions. Preparations with xanthan gum as a binder formed time-dependent release formulations. When used in a concentration of 5.92% in the tablets, 28% drug release was observed in the usual upper gastrointestinal tract conditions. It was also found that enteric coated preparation formulated with 8.88% of kollicoat MAE 100 DP as binder could be used to carry water insoluble drug molecules. The above study shows that chitosan could be successfully used as a binder, for colon targeting of water insoluble drugs in preference to guar gum when used in the same concentration. Additionally, formulations developed with chitosan and kollicoat MAE 100 DP would be highly site specific since drug release would be at a retarded rate till microbial degradation or polymer solubilization takes place in the colon. DOI: http://dx.doi.org/10.3329/dujps.v13i1.21874 Dhaka Univ. J. Pharm. Sci. 13(1): 105-113, 2014 (June)

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“…These systems especially EE15 tablets seem to be promising systems for delivery of drugs to the colon in case of chronological disorders. [25][26][27][28]…”

Section: Resultsmentioning

confidence: 99%

Development and evaluation of colon targeted drug delivery system by using natural Polysaccharides/Polymers

Godge

Hiremath²

2015

Dhaka Univ. J. Pharm. Sci

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“…Calibration Curves were plotted between absorbance observed at D1 for three drugs at selected wavelengths against the concentration in the ranges of 5-30, 5-60 and 5-40 µg/ml for AZI, FLU and SEC respectively. [42][43][44][45]…”

Section: Preparation Of Standard Stock Solutionmentioning

confidence: 99%

Validated Simultaneous Derivative Spectrophotometric Estimation of Azithromycin, Fluconazole and Secnidazole in Bulk and Pharmaceutical Formulation

Raskar,

Kate,

Mungse

et al. 2023

J. Drug Delivery Ther.

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Two simple, sensitive, accurate and precise spectrophotometric methods were developed and validated for the quantitative determination of Azithromycin (AZI), Fluconazole (FLU) and Secnidazole (SEC) in bulk and tablet dosage form. Method A is based on the first-order derivative (D1) and Method B is based on the second-order derivative (D2) spectrophotometric method. In Method A, absorbance was measured at 215nm, 275nm and 333nm being the zero crossing points for AZI, FLU and SEC respectively. In Method B, absorbance was measured at 220nm, 225nm and 211nm being the zero crossing points for AZI, FLU and SEC respectively. For Method A, all three drugs obey Beer’s law in the concentration range 5-30µg/ml for AZI, 5-60 µg/ml for FLU and 5-40 µg/ml for SEC with correlation coefficients 0.995, 0.998 and 0.998 respectively. For Method B, all three drugs obey Beer’s law in the concentration range 5-35 µg/ml for AZI, 5-40 µg/ml for FLU and 5-40 µg/ml for SEC with correlation coefficients 0.995, 0.999 and 0.998 respectively. Both methods can be used for routine analysis of these three drugs in their pharmaceutical dosage form. Results for analysis of both methods were tested and validated for various parameters according to ICH guidelines. Keywords: Derivative, Azithromycin, Fluconazole, Secnidazole

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A spray dried Nelfinavir Mesylate particles for enhanced oral bioavailability: Systematic formulation optimization and in-vivo performance

Kamboj

Sethi

Rana

2019

Colloids and Surfaces B: Biointerfaces

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Preparation and in vitro Evaluation of Inclusion Complexes of Nelfinavir with Chemically Modified ?-cyclodextrins

Cited by 5 publications

References 25 publications

Development and evaluation of colon targeted drug delivery system by using natural Polysaccharides/Polymers

Development and evaluation of colon targeted drug delivery system by using natural Polysaccharides/Polymers

Validated Simultaneous Derivative Spectrophotometric Estimation of Azithromycin, Fluconazole and Secnidazole in Bulk and Pharmaceutical Formulation

A spray dried Nelfinavir Mesylate particles for enhanced oral bioavailability: Systematic formulation optimization and in-vivo performance

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